ID   HXA3A_TAKRU             Reviewed;         417 AA.
AC   Q1KL12;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   24-JAN-2024, entry version 83.
DE   RecName: Full=Homeobox protein Hox-A3a;
GN   Name=hoxa3a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481663; ABF22382.1; -; Genomic_DNA.
DR   RefSeq; XP_003969028.1; XM_003968979.2.
DR   RefSeq; XP_011607396.1; XM_011609094.1.
DR   RefSeq; XP_011607398.1; XM_011609096.1.
DR   RefSeq; XP_011607399.1; XM_011609097.1.
DR   AlphaFoldDB; Q1KL12; -.
DR   SMR; Q1KL12; -.
DR   STRING; 31033.ENSTRUP00000053450; -.
DR   Ensembl; ENSTRUT00000050797.2; ENSTRUP00000053450.1; ENSTRUG00000022811.2.
DR   GeneID; 101068246; -.
DR   KEGG; tru:101068246; -.
DR   CTD; 58049; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159522; -.
DR   InParanoid; Q1KL12; -.
DR   OMA; PAPLNNC; -.
DR   OrthoDB; 728401at2759; -.
DR   Proteomes; UP000005226; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF13; HOMEOBOX PROTEIN HOX-A3; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..417
FT                   /note="Homeobox protein Hox-A3a"
FT                   /id="PRO_0000265965"
FT   DNA_BIND        170..229
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          70..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           133..138
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        72..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..104
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  45024 MW;  727FEA1C35B8B9B3 CRC64;
     MQKATYYDSS AIYSGYPYQS ANGFSYDANQ IQYPRTSHVE SEYHRPACSL QSPGGSVALQ
     KREMAAENCD RTTAVQAVQS KVHPESNQPQ VPVSAPPPPP QSPGAISQTT SNGSNQPTAK
     NSSPTSASRG KQIFPWMKES RQATKQKSTS NTSSVESCPG DKSPPGSAAS KRARTAYTSA
     QLVELEKEFH FNRYLCRPRR VEMANLLNLT ERQIKIWFQN RRMKYKKDQK GAGMMPSPGG
     QSPRSPVGPG STGAGGGGYL NSMHSLVNSV PFESQSPTSY NKPHQNAYGM ATSYPPPLSS
     SHNNCPPTQK RYAGTDSATP EYDAHPLQGN GSYGTHMQGS PVYVGGGYID SVPNSGSSVF
     GLTHLPHPPS ANMDYNGAIT MGNSQHHGVC DPTPTYTDLT SHYSQGRIQE APKLTHL
//