Reviewed, UniProtKB/Swiss-Prot Q1KL10 (HXA1A_TAKRU)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A1a

Gene names

Name:

hoxa1a

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Labial subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Homeobox protein Hox-A1a		PRO_0000265962
Regions
	DNA binding	212 – 271	60	Homeobox
	Motif	187 – 192	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q1KL10-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 279AFA93A0A94DCD	FASTA	325	35,189
	10 20 30 40 50 60 MSSFLDYSVM SGEGSSCSVR AFHSDHGITT FQSCAVSVNN CGTDDRFMAS RASPDGIPHQ 70 80 90 100 110 120 SYQAAVSSLG LAYGAHSACS SSYAPQSFCT TYNHYPLNQE VEPAAGFPQC GPLMYSGNIS 130 140 150 160 170 180 SSVVSQHRQG YGTTPLGQLQ YTHSAYGAGH EQPSPFTGCS NPLSPLHAAH LEACCSPLSE 190 200 210 220 230 240 SASSAQTFDW MKVKRNPPKT GRSGEYGYGG QPNTVRTNFT TKQLTELEKE FHFNKYLTRA 250 260 270 280 290 300 RRVEIAAALQ LNETQVKIWF QNRRMKQKKR EKEGLLPTKP TSSDSGERNQ EKVEDGESEK 310 320 SVSAPSTPSP TSSTVSSGAD SYPSN

References

[1]

"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters." Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B. Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed: 16636282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ481663 Genomic DNA. Translation: ABF22384.1.
3D structure databases
SMR	Q1KL10. Positions 216-269.
ModBase	Search...
Genome annotation databases
Ensembl	ENSTRUT00000040891; ENSTRUP00000040749; ENSTRUG00000015937; Takifugu rubripes. [Genome view]
Phylogenomic databases
HOVERGEN	Q1KL10.
InParanoid	Q1KL10.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. False negative. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA1A_TAKRU

Accession

Primary (citable) accession number: Q1KL10

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 30, 2006
Last modified:	December 15, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)