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Protein

Homeobox protein Hox-A13b

Gene

hoxa13b

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi219 – 278HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A13b
Gene namesi
Name:hoxa13b
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002659741 – 285Homeobox protein Hox-A13bAdd BLAST285

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000039265.

Structurei

3D structure databases

ProteinModelPortaliQ1KKZ6.
SMRiQ1KKZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
InParanoidiQ1KKZ6.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR022067. HoxA13_N.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1KKZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASVLLHSH WIDPVMFLYE NGLDERNKNM EGFTGSNFPA NQCRNLLAHP
60 70 80 90 100
TSLAPNTTYT SNDVPISGIG EPGKQCSPCP ATQSSPNASL PYGYFGSSYY
110 120 130 140 150
PCRVSHGSVK ACAQPSGYGD KYMDSPVSGE EFSSRAKEYA FYQGYSSAPY
160 170 180 190 200
QPSYLDVPVV PALSAPSETR HEPLLPMEPY QPWTITNGWS GQVYCTKEQP
210 220 230 240 250
QSNPLWKSSL QGNSGVRRGR KKRVPYTKVQ LKELEREYAA NKFITKDKRR
260 270 280
RISAQTNLTE RQVTIWFQNR RVKEKKVVNK FKSPS
Length:285
Mass (Da):32,056
Last modified:May 30, 2006 - v1
Checksum:i764BFA47A1A6EEB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481664 Genomic DNA. Translation: ABF22398.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481664 Genomic DNA. Translation: ABF22398.1.

3D structure databases

ProteinModelPortaliQ1KKZ6.
SMRiQ1KKZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000039265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
InParanoidiQ1KKZ6.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR022067. HoxA13_N.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXADB_TAKRU
AccessioniPrimary (citable) accession number: Q1KKZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: February 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.