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Q1KKZ6

- HXADB_TAKRU

UniProt

Q1KKZ6 - HXADB_TAKRU

Protein

Homeobox protein Hox-A13b

Gene

hoxa13b

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi219 – 27860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A13b
    Gene namesi
    Name:hoxa13b
    OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
    Taxonomic identifieri31033 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
    ProteomesiUP000005226: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Homeobox protein Hox-A13bPRO_0000265974Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi31033.ENSTRUP00000039265.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1KKZ6.
    SMRiQ1KKZ6. Positions 212-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG276440.
    InParanoidiQ1KKZ6.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1KKZ6-1 [UniParc]FASTAAdd to Basket

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    MTASVLLHSH WIDPVMFLYE NGLDERNKNM EGFTGSNFPA NQCRNLLAHP    50
    TSLAPNTTYT SNDVPISGIG EPGKQCSPCP ATQSSPNASL PYGYFGSSYY 100
    PCRVSHGSVK ACAQPSGYGD KYMDSPVSGE EFSSRAKEYA FYQGYSSAPY 150
    QPSYLDVPVV PALSAPSETR HEPLLPMEPY QPWTITNGWS GQVYCTKEQP 200
    QSNPLWKSSL QGNSGVRRGR KKRVPYTKVQ LKELEREYAA NKFITKDKRR 250
    RISAQTNLTE RQVTIWFQNR RVKEKKVVNK FKSPS 285
    Length:285
    Mass (Da):32,056
    Last modified:May 30, 2006 - v1
    Checksum:i764BFA47A1A6EEB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ481664 Genomic DNA. Translation: ABF22398.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ481664 Genomic DNA. Translation: ABF22398.1 .

    3D structure databases

    ProteinModelPortali Q1KKZ6.
    SMRi Q1KKZ6. Positions 212-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 31033.ENSTRUP00000039265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG276440.
    InParanoidi Q1KKZ6.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
      Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
      Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHXADB_TAKRU
    AccessioniPrimary (citable) accession number: Q1KKZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3