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Q1KKX7

- HXB3A_TAKRU

UniProt

Q1KKX7 - HXB3A_TAKRU

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Protein

Homeobox protein Hox-B3a

Gene

hoxb3a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi212 – 27160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3a
Gene namesi
Name:hoxb3a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Homeobox protein Hox-B3aPRO_0000265978Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1KKX7.
SMRiQ1KKX7. Positions 212-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi168 – 1736Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
InParanoidiQ1KKX7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KKX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKTTYYDNS STLFGGYSSY QVQGAAAAAA NGFGGYDAPV PVSHHQPAFQ
60 70 80 90 100
SATHLDVDSY QRSACSLQSL GSTNSHQQQQ QLAKTKELNG SCMRSSLPPE
110 120 130 140 150
HHPSSQVSPP LPPNPTNGNS GAQQPGGSAG TSSKSGSNKS STSSSSISSS
160 170 180 190 200
TSSSSSSLPP NPTLAKQIFP WMKECRQTTK QKTCSPSNNS GNGAESGSSG
210 220 230 240 250
EKSPTGGSSA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN
260 270 280 290 300
LSERQIKIWF QNRRMKYKKD QKSKGLSSSS GGPSPTGSPP LTMQSSASYL
310 320 330 340 350
NSMHPMGGGG GYDVPSPPSF GKPHQGVSYA MSTAYSNVPV KGCPPQQKYG
360 370 380 390 400
PPDPDYGDPH PHHSLVQANS AGYGTPTNMQ GSPVYVGGGS YLEPMPGSGP
410 420 430 440 450
SMYGLNHLGP TPTHHQTMDY NGAGPMSATN QHHVGGGGPP GPCDPPTHPT
460 470
YTELSAHHTS SQGRIQEAPK LTHL
Length:474
Mass (Da):49,855
Last modified:May 30, 2006 - v1
Checksum:iF8AF9FEF8D2E1B28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481665 Genomic DNA. Translation: ABF22417.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481665 Genomic DNA. Translation: ABF22417.1 .

3D structure databases

ProteinModelPortali Q1KKX7.
SMRi Q1KKX7. Positions 212-271.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG284589.
InParanoidi Q1KKX7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXB3A_TAKRU
AccessioniPrimary (citable) accession number: Q1KKX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3