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Q1KKX7 (HXB3A_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Homeobox protein Hox-B3a
PRO_0000265978

Regions

DNA binding212 – 27160Homeobox
Motif168 – 1736Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
Q1KKX7 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: F8AF9FEF8D2E1B28

FASTA47449,855
        10         20         30         40         50         60 
MQKTTYYDNS STLFGGYSSY QVQGAAAAAA NGFGGYDAPV PVSHHQPAFQ SATHLDVDSY 

        70         80         90        100        110        120 
QRSACSLQSL GSTNSHQQQQ QLAKTKELNG SCMRSSLPPE HHPSSQVSPP LPPNPTNGNS 

       130        140        150        160        170        180 
GAQQPGGSAG TSSKSGSNKS STSSSSISSS TSSSSSSLPP NPTLAKQIFP WMKECRQTTK 

       190        200        210        220        230        240 
QKTCSPSNNS GNGAESGSSG EKSPTGGSSA SSKRARTAYT SAQLVELEKE FHFNRYLCRP 

       250        260        270        280        290        300 
RRVEMANLLN LSERQIKIWF QNRRMKYKKD QKSKGLSSSS GGPSPTGSPP LTMQSSASYL 

       310        320        330        340        350        360 
NSMHPMGGGG GYDVPSPPSF GKPHQGVSYA MSTAYSNVPV KGCPPQQKYG PPDPDYGDPH 

       370        380        390        400        410        420 
PHHSLVQANS AGYGTPTNMQ GSPVYVGGGS YLEPMPGSGP SMYGLNHLGP TPTHHQTMDY 

       430        440        450        460        470 
NGAGPMSATN QHHVGGGGPP GPCDPPTHPT YTELSAHHTS SQGRIQEAPK LTHL 

« Hide

References

[1]"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ481665 Genomic DNA. Translation: ABF22417.1.

3D structure databases

ProteinModelPortalQ1KKX7.
SMRQ1KKX7. Positions 212-271.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG284589.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXB3A_TAKRU
AccessionPrimary (citable) accession number: Q1KKX7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries