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Q1KKV3

- HXCCA_TAKRU

UniProt

Q1KKV3 - HXCCA_TAKRU

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Protein

Homeobox protein Hox-C12a

Gene

hoxc12a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 26660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C12a
Gene namesi
Name:hoxc12a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Homeobox protein Hox-C12aPRO_0000265992Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000010151.

Structurei

3D structure databases

ProteinModelPortaliQ1KKV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG239684.
GeneTreeiENSGT00760000118834.
InParanoidiQ1KKV3.
KOiK09297.
OMAiQDPPSCQ.
OrthoDBiEOG7FV3R4.
TreeFamiTF351604.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KKV3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR PSGGQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLPWNPSEP CNGYSQSYFS SPVSINPSFN RSCEITRADD GKCYYNNGSG
110 120 130 140 150
SRENCSGGGS LKREDRARDT SALTSDHGMH AGIGSTVAFS KYDYGTEQLT
160 170 180 190 200
QDPPSCQSME SDSSSSLLNE ASKPSSSDTQ TLVSPGSHTG TITASGAAPW
210 220 230 240 250
YPMHTRTRKK RKPYSKLQLA ELEGEFMMNE FITRQRRREL SDRLNLSDQQ
260 270
VKIWFQNRRM KKKRLMLREQ ALAYF
Length:275
Mass (Da):30,735
Last modified:May 30, 2006 - v1
Checksum:i12774925EB97CAA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ481667 Genomic DNA. Translation: ABF22441.1.
RefSeqiXP_003963118.1. XM_003963069.1.

Genome annotation databases

EnsembliENSTRUT00000010207; ENSTRUP00000010151; ENSTRUG00000004280.
GeneIDi101079504.
KEGGitru:101079504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ481667 Genomic DNA. Translation: ABF22441.1 .
RefSeqi XP_003963118.1. XM_003963069.1.

3D structure databases

ProteinModelPortali Q1KKV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000010151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSTRUT00000010207 ; ENSTRUP00000010151 ; ENSTRUG00000004280 .
GeneIDi 101079504.
KEGGi tru:101079504.

Phylogenomic databases

eggNOGi NOG239684.
GeneTreei ENSGT00760000118834.
InParanoidi Q1KKV3.
KOi K09297.
OMAi QDPPSCQ.
OrthoDBi EOG7FV3R4.
TreeFami TF351604.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXCCA_TAKRU
AccessioniPrimary (citable) accession number: Q1KKV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3