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Q1KKV3

- HXCCA_TAKRU

UniProt

Q1KKV3 - HXCCA_TAKRU

Protein

Homeobox protein Hox-C12a

Gene

hoxc12a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi207 – 26660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C12a
    Gene namesi
    Name:hoxc12a
    OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
    Taxonomic identifieri31033 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
    ProteomesiUP000005226: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Homeobox protein Hox-C12aPRO_0000265992Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi31033.ENSTRUP00000010151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1KKV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG239684.
    GeneTreeiENSGT00750000117432.
    InParanoidiQ1KKV3.
    KOiK09297.
    OMAiQDPPSCQ.
    OrthoDBiEOG7FV3R4.
    TreeFamiTF351604.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1KKV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR PSGGQLPGLP SLSYPRRDNV    50
    CSLPWNPSEP CNGYSQSYFS SPVSINPSFN RSCEITRADD GKCYYNNGSG 100
    SRENCSGGGS LKREDRARDT SALTSDHGMH AGIGSTVAFS KYDYGTEQLT 150
    QDPPSCQSME SDSSSSLLNE ASKPSSSDTQ TLVSPGSHTG TITASGAAPW 200
    YPMHTRTRKK RKPYSKLQLA ELEGEFMMNE FITRQRRREL SDRLNLSDQQ 250
    VKIWFQNRRM KKKRLMLREQ ALAYF 275
    Length:275
    Mass (Da):30,735
    Last modified:May 30, 2006 - v1
    Checksum:i12774925EB97CAA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ481667 Genomic DNA. Translation: ABF22441.1.
    RefSeqiXP_003963118.1. XM_003963069.1.

    Genome annotation databases

    EnsembliENSTRUT00000010207; ENSTRUP00000010151; ENSTRUG00000004280.
    GeneIDi101079504.
    KEGGitru:101079504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ481667 Genomic DNA. Translation: ABF22441.1 .
    RefSeqi XP_003963118.1. XM_003963069.1.

    3D structure databases

    ProteinModelPortali Q1KKV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 31033.ENSTRUP00000010151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSTRUT00000010207 ; ENSTRUP00000010151 ; ENSTRUG00000004280 .
    GeneIDi 101079504.
    KEGGi tru:101079504.

    Phylogenomic databases

    eggNOGi NOG239684.
    GeneTreei ENSGT00750000117432.
    InParanoidi Q1KKV3.
    KOi K09297.
    OMAi QDPPSCQ.
    OrthoDBi EOG7FV3R4.
    TreeFami TF351604.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
      Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
      Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHXCCA_TAKRU
    AccessioniPrimary (citable) accession number: Q1KKV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3