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Q1KKT0

- HXDAA_TAKRU

UniProt

Q1KKT0 - HXDAA_TAKRU

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Protein

Homeobox protein Hox-D10a

Gene
hoxd10a
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi262 – 32160HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D10a
Gene namesi
Name:hoxd10a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Homeobox protein Hox-D10aPRO_0000265999Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000044927.

Structurei

3D structure databases

ProteinModelPortaliQ1KKT0.
SMRiQ1KKT0. Positions 250-323.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG274734.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KKT0-1 [UniParc]FASTAAdd to Basket

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MSFPSSSPAA NTFLVDSLIS ACRTDSFYTG SSMYMPPGSE MGTYGMQTCG    50
LLPAFSKRGE VNHQNVGMNV HSYIPQIDNW TDPSRPCRIE SSNQDVQTTH 100
SHQNIKEESN CCMYSDKRVP KVSSSEVPVY SNVAPESCPV DGPEIPVPGY 150
FRLSQTYATG KHQEPYCHDP PDQSPTLIQL TPKPQPAPAS ATFADGESEK 200
NKVPPEPATS RTPIQVESPK SATVEKICSP EASASSPELL QKEGKDSKSD 250
QPANNWLTAK SGRKKRCPYT KHQTLELEKE FLFNMYLTRE RRLEISRSVN 300
LTDRQVKIWF QNRRMKLKKM SRENRIRELT SNLTFS 336
Length:336
Mass (Da):37,706
Last modified:May 30, 2006 - v1
Checksum:i4F666D31642C94FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ481668 Genomic DNA. Translation: ABF22464.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ481668 Genomic DNA. Translation: ABF22464.1 .

3D structure databases

ProteinModelPortali Q1KKT0.
SMRi Q1KKT0. Positions 250-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000044927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG274734.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXDAA_TAKRU
AccessioniPrimary (citable) accession number: Q1KKT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi