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Q1KKS3

- PDE11_TAKRU

UniProt

Q1KKS3 - PDE11_TAKRU

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Protein

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Gene

pde11a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Enzyme regulationi

Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei618 – 6181Proton donorBy similarity
Metal bindingi622 – 6221Divalent metal cation 1By similarity
Metal bindingi658 – 6581Divalent metal cation 1By similarity
Metal bindingi659 – 6591Divalent metal cation 1By similarity
Metal bindingi659 – 6591Divalent metal cation 2By similarity
Metal bindingi662 – 6621Divalent metal cation 2By similarity
Metal bindingi688 – 6881Divalent metal cation 2By similarity
Metal bindingi770 – 7701Divalent metal cation 1By similarity
Binding sitei823 – 8231cAMP or cGMPBy similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC:3.1.4.17, EC:3.1.4.35)
Alternative name(s):
cAMP and cGMP phosphodiesterase 11A
Gene namesi
Name:pde11a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11APRO_0000247043Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000044767.

Structurei

3D structure databases

ProteinModelPortaliQ1KKS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 324150GAF 1Add
BLAST
Domaini356 – 512157GAF 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni594 – 859266CatalyticBy similarityAdd
BLAST

Domaini

The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity (By similarity).By similarity

Sequence similaritiesi

Contains 2 GAF domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiQ1KKS3.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 2 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KKS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVPKMVFSD VESFLDSHPE LFEDYLNRKG SSSMVEKWLK NHQAGKSEAE
60 70 80 90 100
PKEEKSSVCK DSWASKCDGL QRRASQKELR KTFARSKAIN VNRTYDEHVN
110 120 130 140 150
SRAQEPLTSM RRRALLRKAS SLPPTTAHIL SALLESRVNI PQYPSTAVDF
160 170 180 190 200
KYYLKEHNER EFFLELVKDI SNDLDLTSLS YKILVFVCIM VDADRCSLFL
210 220 230 240 250
VEGTGNKKTL VSKFFDVHAG TTVLPSMNSG EVQVPWGKGI IGYVAEHGET
260 270 280 290 300
VNIPDAYQDR RFSDEIDKLT GYKTKSLLCM PIQNSDGEII GVAQAINKSS
310 320 330 340 350
SGELFTEDDE KVLQMYLPFC GIAISNAQLF AASRKEYDRS RALLEVVNDL
360 370 380 390 400
FEEQTDLEKI VRKIMHRAQT LLKCERCSVQ LLEDIESPVV KFTKSFELLS
410 420 430 440 450
PKCSADAESS FKDSMEKSSY SDWLINNSIA ELVASTGLPV NISDAYQDPR
460 470 480 490 500
FDAEADQFSD FHIRSVLCVP IWNSNHQIIG VAQVLNRLDG KPFDDADQRL
510 520 530 540 550
FEAFVIFCGL GINNTIMYDQ VKKSWAKQSV ALDVLSYHAT CSKTEVDKFK
560 570 580 590 600
AANIPLVCEL GIDKLSFDDF SLDVDAMITA ALRMFIELGM VQKFKIDYET
610 620 630 640 650
LCRWLLTVRK NYRMVLYHNW RHAFNVCQCM FAMLTTAGFQ ETLTDVEILA
660 670 680 690 700
LIVGCVCHDL DHRGTNNAFQ AKTGSALSLL YGTSATLEHH HFNHAVMILQ
710 720 730 740 750
SEGHNIFCNL SSTEYSDLMQ LLKQSILATD LTLYFENRNS FFELVSIGEY
760 770 780 790 800
NWNVKTHRDM CRSMMMTACD LGAVTKPWDI SRKVAELVTS EFFEQGDRER
810 820 830 840 850
SELKLTPSAI FDRNRKDELP GLQLEWIDGI CAPLYETLVK LNPKLQPMVD
860 870 880 890 900
MINANRVKWE ELDKKRQHDH GASVPASPCS AAEGSETGGV PCCSNNTPPT

HVS
Length:903
Mass (Da):102,019
Last modified:May 30, 2006 - v1
Checksum:i0B12D6E7897E2E26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481668 Genomic DNA. Translation: ABF22471.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481668 Genomic DNA. Translation: ABF22471.1 .

3D structure databases

ProteinModelPortali Q1KKS3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000044767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi Q1KKS3.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 2 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPDE11_TAKRU
AccessioniPrimary (citable) accession number: Q1KKS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 30, 2006
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3