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Q1KKS3

- PDE11_TAKRU

UniProt

Q1KKS3 - PDE11_TAKRU

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Protein
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Gene
pde11a
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively By similarity.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulationi

Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei618 – 6181Proton donor By similarity
Metal bindingi622 – 6221Divalent metal cation 1 By similarity
Metal bindingi658 – 6581Divalent metal cation 1 By similarity
Metal bindingi659 – 6591Divalent metal cation 1 By similarity
Metal bindingi659 – 6591Divalent metal cation 2 By similarity
Metal bindingi662 – 6621Divalent metal cation 2 By similarity
Metal bindingi688 – 6881Divalent metal cation 2 By similarity
Metal bindingi770 – 7701Divalent metal cation 1 By similarity
Binding sitei823 – 8231cAMP or cGMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC:3.1.4.17, EC:3.1.4.35)
Alternative name(s):
cAMP and cGMP phosphodiesterase 11A
Gene namesi
Name:pde11a
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
PRO_0000247043Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000044767.

Structurei

3D structure databases

ProteinModelPortaliQ1KKS3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 324150GAF 1
Add
BLAST
Domaini356 – 512157GAF 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni594 – 859266Catalytic By similarity
Add
BLAST

Domaini

The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity By similarity.

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiQ1KKS3.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 2 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KKS3-1 [UniParc]FASTAAdd to Basket

« Hide

MAVPKMVFSD VESFLDSHPE LFEDYLNRKG SSSMVEKWLK NHQAGKSEAE    50
PKEEKSSVCK DSWASKCDGL QRRASQKELR KTFARSKAIN VNRTYDEHVN 100
SRAQEPLTSM RRRALLRKAS SLPPTTAHIL SALLESRVNI PQYPSTAVDF 150
KYYLKEHNER EFFLELVKDI SNDLDLTSLS YKILVFVCIM VDADRCSLFL 200
VEGTGNKKTL VSKFFDVHAG TTVLPSMNSG EVQVPWGKGI IGYVAEHGET 250
VNIPDAYQDR RFSDEIDKLT GYKTKSLLCM PIQNSDGEII GVAQAINKSS 300
SGELFTEDDE KVLQMYLPFC GIAISNAQLF AASRKEYDRS RALLEVVNDL 350
FEEQTDLEKI VRKIMHRAQT LLKCERCSVQ LLEDIESPVV KFTKSFELLS 400
PKCSADAESS FKDSMEKSSY SDWLINNSIA ELVASTGLPV NISDAYQDPR 450
FDAEADQFSD FHIRSVLCVP IWNSNHQIIG VAQVLNRLDG KPFDDADQRL 500
FEAFVIFCGL GINNTIMYDQ VKKSWAKQSV ALDVLSYHAT CSKTEVDKFK 550
AANIPLVCEL GIDKLSFDDF SLDVDAMITA ALRMFIELGM VQKFKIDYET 600
LCRWLLTVRK NYRMVLYHNW RHAFNVCQCM FAMLTTAGFQ ETLTDVEILA 650
LIVGCVCHDL DHRGTNNAFQ AKTGSALSLL YGTSATLEHH HFNHAVMILQ 700
SEGHNIFCNL SSTEYSDLMQ LLKQSILATD LTLYFENRNS FFELVSIGEY 750
NWNVKTHRDM CRSMMMTACD LGAVTKPWDI SRKVAELVTS EFFEQGDRER 800
SELKLTPSAI FDRNRKDELP GLQLEWIDGI CAPLYETLVK LNPKLQPMVD 850
MINANRVKWE ELDKKRQHDH GASVPASPCS AAEGSETGGV PCCSNNTPPT 900
HVS 903
Length:903
Mass (Da):102,019
Last modified:May 30, 2006 - v1
Checksum:i0B12D6E7897E2E26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ481668 Genomic DNA. Translation: ABF22471.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ481668 Genomic DNA. Translation: ABF22471.1 .

3D structure databases

ProteinModelPortali Q1KKS3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000044767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi Q1KKS3.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 2 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPDE11_TAKRU
AccessioniPrimary (citable) accession number: Q1KKS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 30, 2006
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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