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Protein

Cytochrome c-b

Gene

cyc-B

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei16 – 161Heme (covalent)PROSITE-ProRule annotation
Binding sitei19 – 191Heme (covalent)PROSITE-ProRule annotation
Metal bindingi20 – 201Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi82 – 821Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-b
Gene namesi
Name:cyc-B
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Cytochrome c-bPRO_0000266004Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Proteomic databases

PRIDEiQ1KKS2.

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000044765.

Structurei

3D structure databases

ProteinModelPortaliQ1KKS2.
SMRiQ1KKS2. Positions 3-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
InParanoidiQ1KKS2.
KOiK08738.
OMAiDANKNGP.
OrthoDBiEOG761BWX.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1KKS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDIAKGKK AFVQKCAQCH TVEQGGKHKT GPNLWGLFGR KTGQAEGFSY
60 70 80 90 100
TDANKSKGII WSEETLMVYL ENPKKYIPGT KMIFAGIKKK TERADLIAYL

KSSTS
Length:105
Mass (Da):11,575
Last modified:May 30, 2006 - v1
Checksum:i4DE3FD6963C7DFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481668 Genomic DNA. Translation: ABF22472.1.
RefSeqiXP_003961875.1. XM_003961826.2.

Genome annotation databases

EnsembliENSTRUT00000044916; ENSTRUP00000044765; ENSTRUG00000017459.
GeneIDi101064386.
KEGGitru:101064386.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ481668 Genomic DNA. Translation: ABF22472.1.
RefSeqiXP_003961875.1. XM_003961826.2.

3D structure databases

ProteinModelPortaliQ1KKS2.
SMRiQ1KKS2. Positions 3-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000044765.

Proteomic databases

PRIDEiQ1KKS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTRUT00000044916; ENSTRUP00000044765; ENSTRUG00000017459.
GeneIDi101064386.
KEGGitru:101064386.

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
InParanoidiQ1KKS2.
KOiK08738.
OMAiDANKNGP.
OrthoDBiEOG761BWX.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCYCB_TAKRU
AccessioniPrimary (citable) accession number: Q1KKS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.