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Q1K722 (KEX1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:B7H23.190, NCU04316
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 659621Pheromone-processing carboxypeptidase kex1
PRO_0000411930

Regions

Topological domain39 – 527489Lumenal Potential
Transmembrane528 – 54821Helical; Potential
Topological domain549 – 659111Cytoplasmic Potential

Sites

Active site1901 By similarity
Active site3931 By similarity
Active site4551 By similarity

Amino acid modifications

Glycosylation2181N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation4521N-linked (GlcNAc...) Potential
Glycosylation5051N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q1K722 [UniParc].

Last modified March 19, 2014. Version 2.
Checksum: 0A063101AF0BDEA3

FASTA65972,836
        10         20         30         40         50         60 
MAATTTTTNA GRSMASWKRL STLIAAFTLS WTSSFVAAAG SADYFVHDLP GAPDGPLVKM 

        70         80         90        100        110        120 
HAGHIEVTPD NNGNLFFWHF QNKHIANKQR TVIWLNGGPG CSSEDGALME IGPYRLKDEN 

       130        140        150        160        170        180 
TLVYNDGAWN EFANVLFVDN PVGTGFSYVD TNAYIHELTE MAANFVTFLE RWFALFPEYE 

       190        200        210        220        230        240 
HDDLYIAGES YAGQHIPYIA QAILERNKNA GPVNRKWNLS GLLIGNGWVS PKEQYDAYLQ 

       250        260        270        280        290        300 
FAYEKDIVKK GTDLANKLEI QQRICQKEIA VKPDKIDYPE CEAILQDMLQ LTAGGVGASG 

       310        320        330        340        350        360 
KNQCYNMYDV RLKDDYPSCG MAWPPDLKSV TPYLRKKEVI KALNINDNKS TGWTECNGQV 

       370        380        390        400        410        420 
GMNFNPKTKP SITLLPDILS AGVPILLFSG AEDLICNHLG TEALISNMEW NGGKGFELTP 

       430        440        450        460        470        480 
GTWAPRRDWT FEGEPAGFWQ QARNLTYVLF YNSSHMVPFD YPRRTRDMLD RFMGVDISSI 

       490        500        510        520        530        540 
GGQPTDSRLD GEKLPETTVG GAAGNSTSNQ AAEKAKLEMA KWEAYRKSGE LVLVIVIVAA 

       550        560        570        580        590        600 
GVWGWFVWKE RRKTAGQGYM GVATGERHSI SNNPGPRGNL SGGGDRTRGQ GLAGFRNKRS 

       610        620        630        640        650 
GRRDVEAQDF DESELDDLHL SKPEDPHADS RYSIGGASDD EEEQKPGKGS SSRQPGGRS 

« Hide

References

[1]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294026 Genomic DNA. Translation: CAD71044.1.
CM002240 Genomic DNA. Translation: EAA31726.3.
RefSeqXP_960962.2. XM_955869.2.
UniGeneNcr.25106.

3D structure databases

ProteinModelPortalQ1K722.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU04316.1.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000003856; EFNCRP00000003856; EFNCRG00000003852.
GeneID3877103.
KEGGncr:NCU04316.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000208879.
KOK01288.
OMAIHELTEM.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_NEUCR
AccessionPrimary (citable) accession number: Q1K722
Secondary accession number(s): Q871G2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 19, 2014
Last modified: June 11, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries