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Q1K722

- KEX1_NEUCR

UniProt

Q1K722 - KEX1_NEUCR

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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901PROSITE-ProRule annotation
Active sitei393 – 3931PROSITE-ProRule annotation
Active sitei455 – 4551PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:B7H23.190, NCU04316
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 659621Pheromone-processing carboxypeptidase kex1PRO_0000411930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU04316.1.

Structurei

3D structure databases

ProteinModelPortaliQ1K722.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 527489LumenalSequence AnalysisAdd
BLAST
Topological domaini549 – 659111CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei528 – 54821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
InParanoidiQ1K722.
KOiK01288.
OMAiIHELTEM.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1K722-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATTTTTNA GRSMASWKRL STLIAAFTLS WTSSFVAAAG SADYFVHDLP
60 70 80 90 100
GAPDGPLVKM HAGHIEVTPD NNGNLFFWHF QNKHIANKQR TVIWLNGGPG
110 120 130 140 150
CSSEDGALME IGPYRLKDEN TLVYNDGAWN EFANVLFVDN PVGTGFSYVD
160 170 180 190 200
TNAYIHELTE MAANFVTFLE RWFALFPEYE HDDLYIAGES YAGQHIPYIA
210 220 230 240 250
QAILERNKNA GPVNRKWNLS GLLIGNGWVS PKEQYDAYLQ FAYEKDIVKK
260 270 280 290 300
GTDLANKLEI QQRICQKEIA VKPDKIDYPE CEAILQDMLQ LTAGGVGASG
310 320 330 340 350
KNQCYNMYDV RLKDDYPSCG MAWPPDLKSV TPYLRKKEVI KALNINDNKS
360 370 380 390 400
TGWTECNGQV GMNFNPKTKP SITLLPDILS AGVPILLFSG AEDLICNHLG
410 420 430 440 450
TEALISNMEW NGGKGFELTP GTWAPRRDWT FEGEPAGFWQ QARNLTYVLF
460 470 480 490 500
YNSSHMVPFD YPRRTRDMLD RFMGVDISSI GGQPTDSRLD GEKLPETTVG
510 520 530 540 550
GAAGNSTSNQ AAEKAKLEMA KWEAYRKSGE LVLVIVIVAA GVWGWFVWKE
560 570 580 590 600
RRKTAGQGYM GVATGERHSI SNNPGPRGNL SGGGDRTRGQ GLAGFRNKRS
610 620 630 640 650
GRRDVEAQDF DESELDDLHL SKPEDPHADS RYSIGGASDD EEEQKPGKGS

SSRQPGGRS
Length:659
Mass (Da):72,836
Last modified:March 19, 2014 - v2
Checksum:i0A063101AF0BDEA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294026 Genomic DNA. Translation: CAD71044.1.
CM002240 Genomic DNA. Translation: EAA31726.3.
RefSeqiXP_960962.2. XM_955869.2.
UniGeneiNcr.25106.

Genome annotation databases

EnsemblFungiiEFNCRT00000003856; EFNCRP00000003856; EFNCRG00000003852.
GeneIDi3877103.
KEGGincr:NCU04316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294026 Genomic DNA. Translation: CAD71044.1 .
CM002240 Genomic DNA. Translation: EAA31726.3 .
RefSeqi XP_960962.2. XM_955869.2.
UniGenei Ncr.25106.

3D structure databases

ProteinModelPortali Q1K722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU04316.1.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000003856 ; EFNCRP00000003856 ; EFNCRG00000003852 .
GeneIDi 3877103.
KEGGi ncr:NCU04316.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000208879.
InParanoidi Q1K722.
KOi K01288.
OMAi IHELTEM.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiKEX1_NEUCR
AccessioniPrimary (citable) accession number: Q1K722
Secondary accession number(s): Q871G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 19, 2014
Last modified: October 29, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3