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Q1K722

- KEX1_NEUCR

UniProt

Q1K722 - KEX1_NEUCR

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 2 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901PROSITE-ProRule annotation
    Active sitei393 – 3931PROSITE-ProRule annotation
    Active sitei455 – 4551PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:B7H23.190, NCU04316
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 2, Linkage Group V

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 659621Pheromone-processing carboxypeptidase kex1PRO_0000411930Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU04316.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1K722.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 527489LumenalSequence AnalysisAdd
    BLAST
    Topological domaini549 – 659111CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei528 – 54821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiIHELTEM.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1K722-1 [UniParc]FASTAAdd to Basket

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    MAATTTTTNA GRSMASWKRL STLIAAFTLS WTSSFVAAAG SADYFVHDLP    50
    GAPDGPLVKM HAGHIEVTPD NNGNLFFWHF QNKHIANKQR TVIWLNGGPG 100
    CSSEDGALME IGPYRLKDEN TLVYNDGAWN EFANVLFVDN PVGTGFSYVD 150
    TNAYIHELTE MAANFVTFLE RWFALFPEYE HDDLYIAGES YAGQHIPYIA 200
    QAILERNKNA GPVNRKWNLS GLLIGNGWVS PKEQYDAYLQ FAYEKDIVKK 250
    GTDLANKLEI QQRICQKEIA VKPDKIDYPE CEAILQDMLQ LTAGGVGASG 300
    KNQCYNMYDV RLKDDYPSCG MAWPPDLKSV TPYLRKKEVI KALNINDNKS 350
    TGWTECNGQV GMNFNPKTKP SITLLPDILS AGVPILLFSG AEDLICNHLG 400
    TEALISNMEW NGGKGFELTP GTWAPRRDWT FEGEPAGFWQ QARNLTYVLF 450
    YNSSHMVPFD YPRRTRDMLD RFMGVDISSI GGQPTDSRLD GEKLPETTVG 500
    GAAGNSTSNQ AAEKAKLEMA KWEAYRKSGE LVLVIVIVAA GVWGWFVWKE 550
    RRKTAGQGYM GVATGERHSI SNNPGPRGNL SGGGDRTRGQ GLAGFRNKRS 600
    GRRDVEAQDF DESELDDLHL SKPEDPHADS RYSIGGASDD EEEQKPGKGS 650
    SSRQPGGRS 659
    Length:659
    Mass (Da):72,836
    Last modified:March 19, 2014 - v2
    Checksum:i0A063101AF0BDEA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294026 Genomic DNA. Translation: CAD71044.1.
    CM002240 Genomic DNA. Translation: EAA31726.3.
    RefSeqiXP_960962.2. XM_955869.2.
    UniGeneiNcr.25106.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000003856; EFNCRP00000003856; EFNCRG00000003852.
    GeneIDi3877103.
    KEGGincr:NCU04316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294026 Genomic DNA. Translation: CAD71044.1 .
    CM002240 Genomic DNA. Translation: EAA31726.3 .
    RefSeqi XP_960962.2. XM_955869.2.
    UniGenei Ncr.25106.

    3D structure databases

    ProteinModelPortali Q1K722.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU04316.1.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000003856 ; EFNCRP00000003856 ; EFNCRG00000003852 .
    GeneIDi 3877103.
    KEGGi ncr:NCU04316.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi IHELTEM.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiKEX1_NEUCR
    AccessioniPrimary (citable) accession number: Q1K722
    Secondary accession number(s): Q871G2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 39 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3