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Q1K6C9

- Q1K6C9_NEUCR

UniProt

Q1K6C9 - Q1K6C9_NEUCR

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Protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2
Gene
NCU09216
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains By similarity.UniRule annotation

Catalytic activityi

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    TransferaseUniRule annotationImported

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2UniRule annotation (EC:2.4.99.18UniRule annotation)
    Short name:
    Oligosaccharyl transferase subunit OST2UniRule annotation
    Gene namesi
    ORF Names:NCU09216Imported
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. oligosaccharyltransferase complex Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulumUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Component of the oligosaccharyltransferase (OST) complex By similarity.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DAD/OST2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    KOiK12668.
    OrthoDBiEOG757D9B.

    Family and domain databases

    InterProiIPR003038. DAD/Ost2.
    [Graphical view]
    PANTHERiPTHR10705. PTHR10705. 1 hit.
    PfamiPF02109. DAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1K6C9-1 [UniParc]FASTAAdd to Basket

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    MGGKRKNAAA ARGVSPTPSA TSTTPSATVT TKVQPKDSAP PIATTTNAFA    50
    TSTQIEPTTT TTTTSTTKAS GTTSKSSSSS NIDKTAAAAA AGGQQAWNKV 100
    FSNLLRHYQD TTPQRTKLLD AFMAFLVVVG GLQFLYCVLA GNYPFNAFLS 150
    GFSATVGQFV LTASLRIQTT EANKSDFPSV SPERAFADYL VCSLILHFFC 200
    VNFIN 205
    Length:205
    Mass (Da):21,571
    Last modified:January 22, 2014 - v2
    Checksum:i1FC16A9357B0EB4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA29924.2.
    RefSeqiXP_959160.1. XM_954067.1.
    UniGeneiNcr.18184.

    Genome annotation databases

    GeneIDi3875282.
    KEGGincr:NCU09216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA29924.2 .
    RefSeqi XP_959160.1. XM_954067.1.
    UniGenei Ncr.18184.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3875282.
    KEGGi ncr:NCU09216.

    Phylogenomic databases

    KOi K12668.
    OrthoDBi EOG757D9B.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR003038. DAD/Ost2.
    [Graphical view ]
    PANTHERi PTHR10705. PTHR10705. 1 hit.
    Pfami PF02109. DAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiQ1K6C9_NEUCR
    AccessioniPrimary (citable) accession number: Q1K6C9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: January 22, 2014
    Last modified: July 9, 2014
    This is version 19 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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