Reviewed, UniProtKB/Swiss-Prot Q1JQA7 (TIGAR_BOVIN)

Names and origin

Protein names

Recommended name:
    Probable fructose-2,6-bisphosphatase TIGAR
    EC=3.1.3.46
Alternative name(s):
    TP53-induced glycolysis and apoptosis regulator

Gene names

Name:

TIGAR

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by TP53 By similarity.
Catalytic activity	Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
Sequence similarities	Belongs to the phosphoglycerate mutase family.
Caution	Not expected to have any kinase activity.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	fructose-2,6-bisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Probable fructose-2,6-bisphosphatase TIGAR		PRO_0000363066
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	198	1	By similarity
Amino acid modifications
	Modified residue	34	1	Phosphothreonine By similarity
	Modified residue	50	1	N6-acetyllysine By similarity
	Modified residue	154	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1JQA7-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 2D738CBE454EA6D8	FASTA	270	29,467
	10 20 30 40 50 60 MTRFALTVVR HGETRLNKEK IIQGQGIDEP LSETGFKQAA AAGIFLKDVK FTHVFSSDLT 70 80 90 100 110 120 RTKQTVHGIL EKSKFCKDMT VKYDSRLRER KYGVAEGRPL SELRAMAKAA GEECPAFTPP 130 140 150 160 170 180 GGETLDQLKR RGKDFFEFLC QLILKEAGQN EQFSQEAPSS CLESSLAEIF PLGKNCASTF 190 200 210 220 230 240 NSDSGTPGLA ASVLVVSHGA YIRSLLDYFL TDLKCSFPAT LSRSELTSVS PNTGMTVFIL 250 260 270 NFEKGGKGRP TAQCVCVNLQ GHLAGVNKTP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116101 mRNA. Translation: AAI16102.1.
IPI	IPI00704255.
RefSeq	NP_001069838.1.
UniGene	Bt.61374
3D structure databases
SMR	Q1JQA7. Positions 1-253.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000022146; ENSBTAP00000022146; ENSBTAG00000016650; Bos taurus. [Genome view]
GeneID	615392.
KEGG	bta:615392.
Organism-specific databases
CTD	615392.
Phylogenomic databases
eggNOG	maNOG16361.
HOVERGEN	Q1JQA7.
InParanoid	Q1JQA7.
OMA	RERKYGV.
OrthoDB	EOG9962BT.
PhylomeDB	Q1JQA7.
Family and domain databases
InterPro	IPR001345. PG/BPGM_mutase_AS. IPR013078. PG_mutase. [Graphical view]
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TIGAR_BOVIN

Accession

Primary (citable) accession number: Q1JQA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 13, 2006
Last modified:	January 19, 2010
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)