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Protein

AP-3 complex subunit sigma-2

Gene

AP3S2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-2
Alternative name(s):
AP-3 complex subunit sigma-3B
Adaptor-related protein complex 3 subunit sigma-2
Sigma-3B-adaptin
Short name:
Sigma3B-adaptin
Sigma-adaptin 3b
Gene namesi
Name:AP3S2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193AP-3 complex subunit sigma-2PRO_0000283806Add
BLAST

Proteomic databases

PaxDbiQ1JQA3.
PRIDEiQ1JQA3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001407.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001846.

Chemistry

BindingDBiQ1JQA3.

Structurei

3D structure databases

ProteinModelPortaliQ1JQA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOVERGENiHBG050517.
InParanoidiQ1JQA3.
KOiK12399.
OMAiIPRNINL.
OrthoDBiEOG091G0QZV.
TreeFamiTF300189.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JQA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL
60 70 80 90 100
EGGSLIGGSD YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHMDKVHYIL QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS
160 170 180 190
EGGLSAAPAR AVSAVKNINL PEMPRNINIG DLNIKVPNLS QFV
Length:193
Mass (Da):22,035
Last modified:June 13, 2006 - v1
Checksum:iD219EF4A9FFED6EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116115 mRNA. Translation: AAI16116.1.
RefSeqiNP_001068844.1. NM_001075376.1.
UniGeneiBt.14403.

Genome annotation databases

EnsembliENSBTAT00000001846; ENSBTAP00000001846; ENSBTAG00000001407.
GeneIDi508867.
KEGGibta:508867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116115 mRNA. Translation: AAI16116.1.
RefSeqiNP_001068844.1. NM_001075376.1.
UniGeneiBt.14403.

3D structure databases

ProteinModelPortaliQ1JQA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001846.

Chemistry

BindingDBiQ1JQA3.

Proteomic databases

PaxDbiQ1JQA3.
PRIDEiQ1JQA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001846; ENSBTAP00000001846; ENSBTAG00000001407.
GeneIDi508867.
KEGGibta:508867.

Organism-specific databases

CTDi10239.

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOVERGENiHBG050517.
InParanoidiQ1JQA3.
KOiK12399.
OMAiIPRNINL.
OrthoDBiEOG091G0QZV.
TreeFamiTF300189.

Gene expression databases

BgeeiENSBTAG00000001407.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP3S2_BOVIN
AccessioniPrimary (citable) accession number: Q1JQA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.