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Protein

Bardet-Biedl syndrome 4 protein homolog

Gene

BBS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 4 protein homolog
Gene namesi
Name:BBS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840421 – 519Bardet-Biedl syndrome 4 protein homologAdd BLAST519

Proteomic databases

PaxDbiQ1JQ97
PRIDEiQ1JQ97

Expressioni

Gene expression databases

BgeeiENSBTAG00000007614

Interactioni

Subunit structurei

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10 (By similarity). Interacts with PCM1 and DCTN1 (By similarity). Interacts with CCDC28B (By similarity). Interacts with ALDOB and C2CD3 (By similarity). Interacts with PKD1 (By similarity). Interacts with CEP290 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6Q9H0F73EBI-2891988,EBI-2891949From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61536N
IntActiQ1JQ97, 2 interactors
STRINGi9913.ENSBTAP00000010013

Structurei

3D structure databases

ProteinModelPortaliQ1JQ97
SMRiQ1JQ97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 100TPR 1Add BLAST34
Repeati101 – 134TPR 2Add BLAST34
Repeati135 – 168TPR 3Add BLAST34
Repeati169 – 201TPR 4Add BLAST33
Repeati203 – 235TPR 5Add BLAST33
Repeati237 – 269TPR 6Add BLAST33
Repeati270 – 303TPR 7Add BLAST34
Repeati304 – 337TPR 8Add BLAST34
Repeati339 – 371TPR 9Add BLAST33
Repeati379 – 417TPR 10Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 66Required for localization to centrosomesBy similarityAdd BLAST66
Regioni101 – 337Interaction with PCM1By similarityAdd BLAST237
Regioni338 – 519Required for localization to centrosomesBy similarityAdd BLAST182

Sequence similaritiesi

Belongs to the BBS4 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00530000063455
HOGENOMiHOG000261391
HOVERGENiHBG024456
InParanoidiQ1JQ97
KOiK16531
OMAiINFQPKM
OrthoDBiEOG091G09T3
TreeFamiTF324966

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 3 hits
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q1JQ97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKLSART QLPVSAESQK PVLKKAPEFP ILEKQNWLIH LYYIQKDYEA
60 70 80 90 100
CKAVIKEQLQ ETHGLCEYAI YVQALIFRLE GNIQESLRLF QMCAFLSPQC
110 120 130 140 150
ADNLKQVARS LFLLGKHKAA IEVYNEAAKL NQKDWEICHN LGVCYIYLKQ
160 170 180 190 200
FDKAQDQLHN ALHLNRHDLT YIMLGKIFLL KGDLDKAIEI YKKAVEFSPE
210 220 230 240 250
NTELLTTLGL LYLQLGIYQK AFEHLGNTLT YDPTNYKAIL AAGSMMQTHG
260 270 280 290 300
DFDVALTKYK VVACAVIESP PLWNNIGMCF FGKKKYVAAI SCLKRANYLA
310 320 330 340 350
PLDWKILYNL GLVHLTMQQY ASAFHFLSAA INFQPKMGEL YMLLAVALTN
360 370 380 390 400
LEDSENAKRA YEEAVRLDKC NPLVNLNYAV LLYNQGEKRD ALAQYQEMEK
410 420 430 440 450
KVNLLKYSSS LEFDPEMVEV AQKLGAALQV GEALVWTKPV KDPKSKHQTA
460 470 480 490 500
STSKAAGFQQ PLGSNQALGQ AMSSAATCRK LSSGAGGTSQ LTKPPSLPLE
510
PEPTVEAQPT EASAQTREK
Length:519
Mass (Da):58,221
Last modified:June 13, 2006 - v1
Checksum:iC96333782E9C2769
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116137 mRNA Translation: AAI16138.1
RefSeqiNP_001069424.1, NM_001075956.1
UniGeneiBt.7716

Genome annotation databases

EnsembliENSBTAT00000010013; ENSBTAP00000010013; ENSBTAG00000007614
GeneIDi532120
KEGGibta:532120

Similar proteinsi

Entry informationi

Entry nameiBBS4_BOVIN
AccessioniPrimary (citable) accession number: Q1JQ97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 13, 2006
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health