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Protein

Bardet-Biedl syndrome 4 protein homolog

Gene

BBS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-5620922. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 4 protein homolog
Gene namesi
Name:BBS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Bardet-Biedl syndrome 4 protein homologPRO_0000284042Add
BLAST

Proteomic databases

PaxDbiQ1JQ97.
PRIDEiQ1JQ97.

Interactioni

Subunit structurei

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10 (By similarity). Interacts with PCM1 and DCTN1 (By similarity). Interacts with CCDC28B (By similarity). Interacts with ALDOB and C2CD3 (By similarity). Interacts with PKD1 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-61536N.
IntActiQ1JQ97. 2 interactions.
STRINGi9913.ENSBTAP00000010013.

Structurei

3D structure databases

ProteinModelPortaliQ1JQ97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 10034TPR 1Add
BLAST
Repeati101 – 13434TPR 2Add
BLAST
Repeati135 – 16834TPR 3Add
BLAST
Repeati169 – 20133TPR 4Add
BLAST
Repeati203 – 23533TPR 5Add
BLAST
Repeati237 – 26933TPR 6Add
BLAST
Repeati270 – 30334TPR 7Add
BLAST
Repeati304 – 33734TPR 8Add
BLAST
Repeati339 – 37133TPR 9Add
BLAST
Repeati379 – 41739TPR 10Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6666Required for localization to centrosomesBy similarityAdd
BLAST
Regioni101 – 337237Interaction with PCM1By similarityAdd
BLAST
Regioni338 – 519182Required for localization to centrosomesBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the BBS4 family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00530000063455.
HOGENOMiHOG000261391.
HOVERGENiHBG024456.
InParanoidiQ1JQ97.
KOiK16531.
OMAiQETHGLC.
OrthoDBiEOG7PS1HB.
TreeFamiTF324966.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR028786. BBS4.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR23083:SF398. PTHR23083:SF398. 1 hit.
PfamiPF13414. TPR_11. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JQ97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKLSART QLPVSAESQK PVLKKAPEFP ILEKQNWLIH LYYIQKDYEA
60 70 80 90 100
CKAVIKEQLQ ETHGLCEYAI YVQALIFRLE GNIQESLRLF QMCAFLSPQC
110 120 130 140 150
ADNLKQVARS LFLLGKHKAA IEVYNEAAKL NQKDWEICHN LGVCYIYLKQ
160 170 180 190 200
FDKAQDQLHN ALHLNRHDLT YIMLGKIFLL KGDLDKAIEI YKKAVEFSPE
210 220 230 240 250
NTELLTTLGL LYLQLGIYQK AFEHLGNTLT YDPTNYKAIL AAGSMMQTHG
260 270 280 290 300
DFDVALTKYK VVACAVIESP PLWNNIGMCF FGKKKYVAAI SCLKRANYLA
310 320 330 340 350
PLDWKILYNL GLVHLTMQQY ASAFHFLSAA INFQPKMGEL YMLLAVALTN
360 370 380 390 400
LEDSENAKRA YEEAVRLDKC NPLVNLNYAV LLYNQGEKRD ALAQYQEMEK
410 420 430 440 450
KVNLLKYSSS LEFDPEMVEV AQKLGAALQV GEALVWTKPV KDPKSKHQTA
460 470 480 490 500
STSKAAGFQQ PLGSNQALGQ AMSSAATCRK LSSGAGGTSQ LTKPPSLPLE
510
PEPTVEAQPT EASAQTREK
Length:519
Mass (Da):58,221
Last modified:June 13, 2006 - v1
Checksum:iC96333782E9C2769
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116137 mRNA. Translation: AAI16138.1.
RefSeqiNP_001069424.1. NM_001075956.1.
UniGeneiBt.7716.

Genome annotation databases

EnsembliENSBTAT00000010013; ENSBTAP00000010013; ENSBTAG00000007614.
GeneIDi532120.
KEGGibta:532120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116137 mRNA. Translation: AAI16138.1.
RefSeqiNP_001069424.1. NM_001075956.1.
UniGeneiBt.7716.

3D structure databases

ProteinModelPortaliQ1JQ97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61536N.
IntActiQ1JQ97. 2 interactions.
STRINGi9913.ENSBTAP00000010013.

Proteomic databases

PaxDbiQ1JQ97.
PRIDEiQ1JQ97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010013; ENSBTAP00000010013; ENSBTAG00000007614.
GeneIDi532120.
KEGGibta:532120.

Organism-specific databases

CTDi585.

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00530000063455.
HOGENOMiHOG000261391.
HOVERGENiHBG024456.
InParanoidiQ1JQ97.
KOiK16531.
OMAiQETHGLC.
OrthoDBiEOG7PS1HB.
TreeFamiTF324966.

Enzyme and pathway databases

ReactomeiR-BTA-5620922. BBSome-mediated cargo-targeting to cilium.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR028786. BBS4.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR23083:SF398. PTHR23083:SF398. 1 hit.
PfamiPF13414. TPR_11. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiBBS4_BOVIN
AccessioniPrimary (citable) accession number: Q1JQ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 13, 2006
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.