Q1JQ92 (POP5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P/MRP protein subunit POP5
EC=3.1.26.5

Gene names

Name:

POP5

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Miscellaneous	The last C-terminal 19 amino acids are not required for complex association and RNase activity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Ribonuclease P/MRP protein subunit POP5		PRO_0000327379

Sequences

	Sequence		Length	Mass (Da)
	Q1JQ92 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 712668C4F7745A8C	FASTA	170	19,351
	10 20 30 40 50 60 MVRFKHRYLL CEVVSDDPRC RLTLEDRVLG TLVRDTIARV HGTFGAAACS IGFAVRYLNA 70 80 90 100 110 120 YTGIVLLRCR KEFYRLVWSA LPFITSLENK GHRYPCFLNT LHVGGTIRTC QKFLIQYNRR 130 140 150 160 170 QLLILLQNCT DEGEREAIQK SVTKSCLLEE ESAGEELSDS GGEETAEPME

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116153 mRNA. Translation: AAI16154.1.
IPI	IPI00688426.
RefSeq	NP_001068780.1. NM_001075312.2.
UniGene	Bt.10352.
3D structure databases
ProteinModelPortal	Q1JQ92.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000007083.
Proteomic databases
PRIDE	Q1JQ92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	507410.
KEGG	bta:507410.
Organism-specific databases
CTD	51367.
Phylogenomic databases
eggNOG	COG1369.
HOGENOM	HOG000293345.
HOVERGEN	HBG082157.
InParanoid	Q1JQ92.
KO	K03537.
OrthoDB	EOG49W2GX.
Enzyme and pathway databases
BioCyc	CATTLE:507410-MONOMER.
Family and domain databases
InterPro	IPR016819. RNase_P/MRP_POP5. IPR002759. RNase_P/MRP_subunit. [Graphical view]
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
PIRSF	PIRSF023803. Ribonuclease_P_prd. 1 hit.
ProtoNet	Search...
Other
NextBio	20868044.

Entry information

Entry name

POP5_BOVIN

Accession

Primary (citable) accession number: Q1JQ92

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 13, 2006
Last modified:	May 29, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program