Q1JPS6 (OPN4L_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanopsin-like

Alternative name(s):
Melanopsin
Opsin-4-like

Gene names

Name:	opn4l
Synonyms:	opn4c, opn4m2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Photoreceptor implicated in non-image-forming responses to light By similarity. UniProtKB Q9QXZ9
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in a subset of retinal horizontal cells. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	G-protein coupled receptor Photoreceptor protein Receptor Retinal protein Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	light-induced release of internally sequestered calcium ion Inferred from direct assay. Source: ZFIN protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor activity Inferred from direct assay. Source: ZFIN
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Melanopsin-like		PRO_0000270989
Regions
	Topological domain	1 – 65	65	Extracellular Potential
	Transmembrane	66 – 86	21	Helical; Name=1; Potential
	Topological domain	87 – 101	15	Cytoplasmic Potential
	Transmembrane	102 – 122	21	Helical; Name=2; Potential
	Topological domain	123 – 138	16	Extracellular Potential
	Transmembrane	139 – 159	21	Helical; Name=3; Potential
	Topological domain	160 – 182	23	Cytoplasmic Potential
	Transmembrane	183 – 203	21	Helical; Name=4; Potential
	Topological domain	204 – 232	29	Extracellular Potential
	Transmembrane	233 – 253	21	Helical; Name=5; Potential
	Topological domain	254 – 286	33	Cytoplasmic Potential
	Transmembrane	287 – 307	21	Helical; Name=6; Potential
	Topological domain	308 – 322	15	Extracellular Potential
	Transmembrane	323 – 343	21	Helical; Name=7; Potential
	Topological domain	344 – 500	157	Cytoplasmic Potential
Amino acid modifications
	Modified residue	330	1	N6-(retinylidene)lysine By similarity
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	137 ↔ 215		Potential
Experimental info
	Sequence conflict	185	1	L → F in AAL82577. Ref.1
	Sequence conflict	293	1	V → L in AAL82577. Ref.1
	Sequence conflict	387	1	S → SH in AAL82577. Ref.1
	Sequence conflict	452	1	S → P in AAL82577. Ref.1
	Sequence conflict	471	1	I → V in AAL82577. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q1JPS6 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 4D0895F1CAAA12B2	FASTA	500	54,490
	10 20 30 40 50 60 MSHHSSWRGH HCAPGDINCT AGFKESLGSR NYKLLHVPVH GPTHSHHHDP PHPFPTVDVP 70 80 90 100 110 120 DHAHYIIGSV ILIVGITGVI GNALVVYVFC RSRTLRTAGN MFIVNLAVAD FLMSVTQSPV 130 140 150 160 170 180 FFAASLHRRW VFGERPCELY AFCGALFGIC SMMTLTAIAA DRCLAITQPL ALVSRVSRRK 190 200 210 220 230 240 AGAVLVVVWL YSLGWSLPPF FGWSAYVPEG LQTSCSWDYM TFTPSVRAYT ILLFVFVFFI 250 260 270 280 290 300 PLGIIGSCYF AIFQTIRAAG KEIRELDCGE THKVYERMQN EWKMAKVALV VIVLFIISWS 310 320 330 340 350 360 PYSVVALTAT AGYSHFLTPY MNSVPAVIAK ASAIHNPIIY AITHPKYRVA IARYIPVLRP 370 380 390 400 410 420 ILRVKEKDLR SSFSSGSVSS RRPTLTSQCS LGVSMGNAAR ANGRWGKTRL SSASDSDSCW 430 440 450 460 470 480 TESEADGSSV SSLTFGRRVS TEISTDTVIL SSGSSVSNAS GQKSERAHKV ISVPVPSITF 490 500 ETDAADGESL SDGKALLGGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position." Bellingham J., Whitmore D., Philp A.R., Wells D.J., Foster R.G. Brain Res. Mol. Brain Res. 107:128-136(2002) [PubMed: 12487121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Retina.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY078161 mRNA. Translation: AAL82577.1. BC116614 mRNA. Translation: AAI16615.1.
IPI	IPI00508591.
RefSeq	NP_840074.1. NM_178289.2.
UniGene	Dr.24957.
3D structure databases
ProteinModelPortal	Q1JPS6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JPS6.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000018501; ENSDARP00000002787; ENSDARG00000007553.
GeneID	352918.
KEGG	dre:352918.
NMPDR	fig|7955.3.peg.11393.
Organism-specific databases
CTD	352918.
ZFIN	ZDB-GENE-030314-2. opn4l.
Phylogenomic databases
eggNOG	fiNOG05743.
GeneTree	ENSGT00560000077171.
HOGENOM	HBG716226.
HOVERGEN	HBG007871.
InParanoid	Q1JPS6.
OMA	DINCTAG.
OrthoDB	EOG40VVRJ.
PhylomeDB	Q1JPS6.
Gene expression databases
ArrayExpress	Q1JPS6.
Bgee	Q1JPS6.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001760. Opsin. [Graphical view]
KO	K04255.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00238. OPSIN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS00238. OPSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OPN4L_DANRE

Accession

Primary (citable) accession number: Q1JPS6
Secondary accession number(s): Q8AV31

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program