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Protein

Protein-lysine N-methyltransferase EEF2KMT

Gene

EEF2KMT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei238 – 2381S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei257 – 2571S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine N-methyltransferase EEF2KMTCurated (EC:2.1.1.-By similarity)
Alternative name(s):
eEF2-lysine methyltransferase
Short name:
eEF2-KMT
Gene namesi
Name:EEF2KMT
Synonyms:FAM86A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Protein-lysine N-methyltransferase EEF2KMTPRO_0000332111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ1JPJ9.
PRIDEiQ1JPJ9.

Interactioni

Subunit structurei

Interacts with FAM86B2 and FAM86C1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037316.

Structurei

3D structure databases

ProteinModelPortaliQ1JPJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 1673S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2497. Eukaryota.
ENOG410ZQK4. LUCA.
HOGENOMiHOG000067842.
HOVERGENiHBG059594.
InParanoidiQ1JPJ9.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029426. FAM86.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF14904. FAM86. 1 hit.
PF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JPJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEERADAA RLLRGFERRF LAARALRSFP WQSLEEKLRD SSGSELLLDI
60 70 80 90 100
LQKTVKHPLC VKHPPSVKYS RSFLSELIRK HEAVHTEPLD ELYQALAEVL
110 120 130 140 150
TAEDPTHCHR SYLLPSGDSV TLCESTAIVS HGTTGLVTWN AALYLAEWAV
160 170 180 190 200
ENPAVFAHRM VLELGSGAGL TGLAICKTCR PRAYIFSDCH SHVLEQLRGN
210 220 230 240 250
VLLNGFSLEP SIDTWAQHPG PHTPEAERPW VTVARLDWDT VTAPQLAAFQ
260 270 280 290 300
PDVVLAADVL YCPETVLSLV GVLRKLSTCR KDQRAPDAYI AFTVRNPETC
310 320 330 340
QLFTTELGQA GIPWEEVPCH DQKLFPYEEH SEMAILKLTL
Length:340
Mass (Da):37,952
Last modified:April 29, 2008 - v2
Checksum:i587BF0CCBCC093CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03051150 Genomic DNA. No translation available.
BT025354 mRNA. Translation: ABF57310.1.
RefSeqiNP_001157410.1. NM_001163938.1.
UniGeneiBt.16949.

Genome annotation databases

GeneIDi531984.
KEGGibta:531984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03051150 Genomic DNA. No translation available.
BT025354 mRNA. Translation: ABF57310.1.
RefSeqiNP_001157410.1. NM_001163938.1.
UniGeneiBt.16949.

3D structure databases

ProteinModelPortaliQ1JPJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037316.

Proteomic databases

PaxDbiQ1JPJ9.
PRIDEiQ1JPJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi531984.
KEGGibta:531984.

Organism-specific databases

CTDi196483.

Phylogenomic databases

eggNOGiKOG2497. Eukaryota.
ENOG410ZQK4. LUCA.
HOGENOMiHOG000067842.
HOVERGENiHBG059594.
InParanoidiQ1JPJ9.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029426. FAM86.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF14904. FAM86. 1 hit.
PF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-340.

Entry informationi

Entry nameiEF2KT_BOVIN
AccessioniPrimary (citable) accession number: Q1JPJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 8, 2016
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.