Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1JPJ8

- THOP1_BOVIN

UniProt

Q1JPJ8 - THOP1_BOVIN

Protein

Thimet oligopeptidase

Gene

THOP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments By similarity.By similarity

    Catalytic activityi

    Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi473 – 4731Zinc; catalyticPROSITE-ProRule annotation
    Active sitei474 – 4741PROSITE-ProRule annotation
    Metal bindingi477 – 4771Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi480 – 4801Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: Ensembl

    GO - Biological processi

    1. peptide metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thimet oligopeptidase (EC:3.4.24.15)
    Gene namesi
    Name:THOP1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 687687Thimet oligopeptidasePRO_0000263069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei278 – 2781PhosphotyrosineBy similarity
    Modified residuei538 – 5381N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ1JPJ8.
    PRIDEiQ1JPJ8.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JPJ8.
    SMRiQ1JPJ8. Positions 24-677.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0339.
    GeneTreeiENSGT00550000074738.
    HOGENOMiHOG000245985.
    HOVERGENiHBG000238.
    InParanoidiQ1JPJ8.
    KOiK01392.
    OrthoDBiEOG7SR4KW.
    TreeFamiTF300459.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1JPJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPPAACTGD ALDVVAPCSA VNHLRWDLSA QQIAELTTEL IEQTKRVYDC    50
    VGAQEPQDVS YENTLKALAD VEVSYTVQRN ILDFPQHVSP SKDIRTASTE 100
    ADKKLSEFDV EMSMRQDVYQ RIVWLQEKVQ KDSLRPEASR YLERLIKLGR 150
    RNGLHLPEET QEKIKSIKKK LSLLCIDFNK NLNEDTTFLP FTREELGGLP 200
    EDFLNSLEKT EDEKLKVTLK YPHYFPLLKK CHVPETRRKV EEAFNCRCKE 250
    ENCAILRELV RLRAQKSRLL GFSTHADYVL EMNMAKTSQV VATFLDELAQ 300
    KLKPLGEQER AVILELKRAE CEQRGLAFDG RINAWDMRYY MNQVEETRYR 350
    VDQNLLKEYF PMQVVTRGLL GIYQELLGLS FQLEEGAAVW HEDVALYAVR 400
    DAASGKLIGK FYLDLYPREG KYGHAACFGL QPGCLRKDGS RQIAIAAMVA 450
    NFTKPTPDAP SLLQHDEVET YFHEFGHVMH QLCSQAEFAM FSGTHVERDF 500
    VEAPSQMLEN WVWEAEPLLR MSQHYRTGSS IPQELLDKLI KSRQANTGLF 550
    NLRQIVLAKV DQALHTQTAA DPAKEYARLC QEILGVPATP GTNMPATFGH 600
    LAGGYDAQYY GYLWSEVYSA DMFHTRFKQE GVLSGKVGMD YRSCILRPGG 650
    SEDASVMLKL FLGRDPKQDA FLLSKGLQVE GCEPPAC 687
    Length:687
    Mass (Da):78,139
    Last modified:January 23, 2007 - v3
    Checksum:i70627C332F5A7B8B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501C → R in AAI49984. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025355 mRNA. Translation: ABF57311.1.
    BC149983 mRNA. Translation: AAI49984.1.
    RefSeqiNP_001029163.2. NM_001033991.3.
    UniGeneiBt.21827.

    Genome annotation databases

    EnsembliENSBTAT00000027246; ENSBTAP00000027246; ENSBTAG00000020446.
    GeneIDi510889.
    KEGGibta:510889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025355 mRNA. Translation: ABF57311.1 .
    BC149983 mRNA. Translation: AAI49984.1 .
    RefSeqi NP_001029163.2. NM_001033991.3.
    UniGenei Bt.21827.

    3D structure databases

    ProteinModelPortali Q1JPJ8.
    SMRi Q1JPJ8. Positions 24-677.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.001.

    Proteomic databases

    PaxDbi Q1JPJ8.
    PRIDEi Q1JPJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000027246 ; ENSBTAP00000027246 ; ENSBTAG00000020446 .
    GeneIDi 510889.
    KEGGi bta:510889.

    Organism-specific databases

    CTDi 7064.

    Phylogenomic databases

    eggNOGi COG0339.
    GeneTreei ENSGT00550000074738.
    HOGENOMi HOG000245985.
    HOVERGENi HBG000238.
    InParanoidi Q1JPJ8.
    KOi K01392.
    OrthoDBi EOG7SR4KW.
    TreeFami TF300459.

    Miscellaneous databases

    NextBioi 20869665.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiTHOP1_BOVIN
    AccessioniPrimary (citable) accession number: Q1JPJ8
    Secondary accession number(s): A6QQT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3