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Q1JPJ8

- THOP1_BOVIN

UniProt

Q1JPJ8 - THOP1_BOVIN

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Protein
Thimet oligopeptidase
Gene
THOP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments By similarity.

Catalytic activityi

Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi473 – 4731Zinc; catalytic By similarity
Active sitei474 – 4741 By similarity
Metal bindingi477 – 4771Zinc; catalytic By similarity
Metal bindingi480 – 4801Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: Ensembl

GO - Biological processi

  1. peptide metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Thimet oligopeptidase (EC:3.4.24.15)
Gene namesi
Name:THOP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 687687Thimet oligopeptidase
PRO_0000263069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781Phosphotyrosine By similarity
Modified residuei538 – 5381N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ1JPJ8.
PRIDEiQ1JPJ8.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ1JPJ8.
SMRiQ1JPJ8. Positions 24-677.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Phylogenomic databases

eggNOGiCOG0339.
GeneTreeiENSGT00550000074738.
HOGENOMiHOG000245985.
HOVERGENiHBG000238.
InParanoidiQ1JPJ8.
KOiK01392.
OrthoDBiEOG7SR4KW.
TreeFamiTF300459.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JPJ8-1 [UniParc]FASTAAdd to Basket

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MKPPAACTGD ALDVVAPCSA VNHLRWDLSA QQIAELTTEL IEQTKRVYDC    50
VGAQEPQDVS YENTLKALAD VEVSYTVQRN ILDFPQHVSP SKDIRTASTE 100
ADKKLSEFDV EMSMRQDVYQ RIVWLQEKVQ KDSLRPEASR YLERLIKLGR 150
RNGLHLPEET QEKIKSIKKK LSLLCIDFNK NLNEDTTFLP FTREELGGLP 200
EDFLNSLEKT EDEKLKVTLK YPHYFPLLKK CHVPETRRKV EEAFNCRCKE 250
ENCAILRELV RLRAQKSRLL GFSTHADYVL EMNMAKTSQV VATFLDELAQ 300
KLKPLGEQER AVILELKRAE CEQRGLAFDG RINAWDMRYY MNQVEETRYR 350
VDQNLLKEYF PMQVVTRGLL GIYQELLGLS FQLEEGAAVW HEDVALYAVR 400
DAASGKLIGK FYLDLYPREG KYGHAACFGL QPGCLRKDGS RQIAIAAMVA 450
NFTKPTPDAP SLLQHDEVET YFHEFGHVMH QLCSQAEFAM FSGTHVERDF 500
VEAPSQMLEN WVWEAEPLLR MSQHYRTGSS IPQELLDKLI KSRQANTGLF 550
NLRQIVLAKV DQALHTQTAA DPAKEYARLC QEILGVPATP GTNMPATFGH 600
LAGGYDAQYY GYLWSEVYSA DMFHTRFKQE GVLSGKVGMD YRSCILRPGG 650
SEDASVMLKL FLGRDPKQDA FLLSKGLQVE GCEPPAC 687
Length:687
Mass (Da):78,139
Last modified:January 23, 2007 - v3
Checksum:i70627C332F5A7B8B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501C → R in AAI49984. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT025355 mRNA. Translation: ABF57311.1.
BC149983 mRNA. Translation: AAI49984.1.
RefSeqiNP_001029163.2. NM_001033991.3.
UniGeneiBt.21827.

Genome annotation databases

EnsembliENSBTAT00000027246; ENSBTAP00000027246; ENSBTAG00000020446.
GeneIDi510889.
KEGGibta:510889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT025355 mRNA. Translation: ABF57311.1 .
BC149983 mRNA. Translation: AAI49984.1 .
RefSeqi NP_001029163.2. NM_001033991.3.
UniGenei Bt.21827.

3D structure databases

ProteinModelPortali Q1JPJ8.
SMRi Q1JPJ8. Positions 24-677.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.001.

Proteomic databases

PaxDbi Q1JPJ8.
PRIDEi Q1JPJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000027246 ; ENSBTAP00000027246 ; ENSBTAG00000020446 .
GeneIDi 510889.
KEGGi bta:510889.

Organism-specific databases

CTDi 7064.

Phylogenomic databases

eggNOGi COG0339.
GeneTreei ENSGT00550000074738.
HOGENOMi HOG000245985.
HOVERGENi HBG000238.
InParanoidi Q1JPJ8.
KOi K01392.
OrthoDBi EOG7SR4KW.
TreeFami TF300459.

Miscellaneous databases

NextBioi 20869665.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiTHOP1_BOVIN
AccessioniPrimary (citable) accession number: Q1JPJ8
Secondary accession number(s): A6QQT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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