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Protein

NADPH-dependent diflavin oxidoreductase 1

Gene

NDOR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei132FMNUniRule annotation1
Binding sitei350FADUniRule annotation1
Binding sitei460NADPUniRule annotation1
Binding sitei558NADPUniRule annotation1
Binding sitei596FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17FMNUniRule annotation6
Nucleotide bindingi59 – 62FMNUniRule annotation4
Nucleotide bindingi97 – 106FMNUniRule annotation10
Nucleotide bindingi382 – 385FADUniRule annotation4
Nucleotide bindingi416 – 419FADUniRule annotation4
Nucleotide bindingi515 – 516NADPUniRule annotation2
Nucleotide bindingi521 – 525NADPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent diflavin oxidoreductase 1UniRule annotation (EC:1.18.1.-UniRule annotation)
Alternative name(s):
NADPH-dependent FMN and FAD-containing oxidoreductaseUniRule annotation
Gene namesi
Name:NDOR1UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:31938 NDOR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195381 – 597NADPH-dependent diflavin oxidoreductase 1Add BLAST597

Proteomic databases

PaxDbiQ1JPJ0
PRIDEiQ1JPJ0

Expressioni

Gene expression databases

BgeeiENSBTAG00000047061

Interactioni

Subunit structurei

Interacts with CIAPIN1. Interacts with DCPS.UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054403

Structurei

3D structure databases

ProteinModelPortaliQ1JPJ0
SMRiQ1JPJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 150Flavodoxin-likeUniRule annotationAdd BLAST145
Domaini206 – 446FAD-binding FR-typeUniRule annotationAdd BLAST241

Sequence similaritiesi

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1159 Eukaryota
COG0369 LUCA
GeneTreeiENSGT00900000141135
HOVERGENiHBG104950
InParanoidiQ1JPJ0
OMAiGPSHFQD
OrthoDBiEOG091G0GP1
TreeFamiTF105716

Family and domain databases

Gene3Di1.20.990.10, 1 hit
3.40.50.360, 1 hit
HAMAPiMF_03178 NDOR1, 1 hit
InterProiView protein in InterPro
IPR003097 FAD-binding_1
IPR017927 Fd_Rdtase_FAD-bd
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR028879 NDOR1
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q1JPJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSARLLVLF GSQTGTAQDV SERLGREARR RQLSCRVEEL DSYPVVNLIN
60 70 80 90 100
EPLVIFVCAT TGQGDPPDNM KSFWRFIFRR SLPSTALRQM DFAVLGLGDS
110 120 130 140 150
SYAKFNFVAK KLHRRLLQLG GSALLPVCLG DDQHELGPDA AIDPWLQDLW
160 170 180 190 200
EKVLGPHPVP LNLDLSPPGV LWPSKFTLQF LKDTPSSGPE ELCAAGTDPQ
210 220 230 240 250
GPPSELQPFL APMVSNQRVT GPSHFQDVRL IEFDISGSGI SFAAGDLVLI
260 270 280 290 300
QPENTASHVQ QFCQALGLDP EQHFTLQPRE PGVTCPTRLP QPCSVRRLVS
310 320 330 340 350
QYLDIASVPR RSFFELLACL SPHELEREKL WEFGSARGQE ELCEYCTRPR
360 370 380 390 400
RTALEVLCDF PHTAAAVPPD YLLDLLPLIR PRAFSIASSL RAHPSRLQIL
410 420 430 440 450
VAVVQYQTRL REPRRGLCSS WLASLDPAQG PVRVPLWVRS GGLTFPKTPD
460 470 480 490 500
VPVIMVGPGT GVAPFRAAIQ ERVAQGETGN VLFFGCRRRD QDFYWEAEWE
510 520 530 540 550
QLQARGCLTL VTAFSREQEQ KVYVQHRLRA LGPLVWELLD GRGAHFYLAG
560 570 580 590
NAKYMPADVC DTLLSIFREE GGLSDPDAAA YLAQLQRTLR FQTETWA
Length:597
Mass (Da):66,568
Last modified:October 16, 2013 - v2
Checksum:i01CA1B51157D58E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti331W → R in ABF57319 (PubMed:16305752).Curated1
Sequence conflicti398Q → H in ABF57319 (PubMed:16305752).Curated1
Sequence conflicti542R → G in ABF57319 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025363 mRNA Translation: ABF57319.1
DAAA02032411 Genomic DNA No translation available.
RefSeqiNP_001039623.2, NM_001046158.2
UniGeneiBt.27888

Genome annotation databases

EnsembliENSBTAT00000066145; ENSBTAP00000054403; ENSBTAG00000047061
GeneIDi513873
KEGGibta:513873

Similar proteinsi

Entry informationi

Entry nameiNDOR1_BOVIN
AccessioniPrimary (citable) accession number: Q1JPJ0
Secondary accession number(s): G3MXY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 16, 2013
Last modified: March 28, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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