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Protein

Pyruvate kinase

Gene

PKLR

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS)
  2. Phosphoglycerate kinase 1 (PGK1)
  3. no protein annotated in this organism
  4. Beta-enolase (ENO3), Alpha-enolase (ENO1)
  5. Pyruvate kinase (PKM2), Pyruvate kinase (PKLR), Pyruvate kinase (PKM2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

ReactomeiR-BTA-70171. Glycolysis.
SABIO-RKQ1JPG7.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:PKLRImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSBTAG00000017056.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044193.

Structurei

3D structure databases

SMRiQ1JPG7. Positions 9-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 389352PKInterPro annotationAdd
BLAST
Domaini406 – 523118PK_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
HOVERGENiHBG000941.
KOiK12406.
OMAiPFERSED.
OrthoDBiEOG091G0597.
TreeFamiTF300390.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JPG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQIPGDRQR QQLPATMADT FLEHLCLLDI DSEPVVARST SIIATIGPAS
60 70 80 90 100
RSVERLKEMI EAGMNIARLN FSHGSHEYHA ESIANIREAV ESFANSPLSY
110 120 130 140 150
RPVAIALDTK GPEIRTGILQ GDPASEVEIV KGSRVLVTVD PEFQTRGDAN
160 170 180 190 200
TVWVDYPNIV RVMPVGGRIY IDDGLISLVV KKIGPEGLET EVENGGVLGS
210 220 230 240 250
RKGVNLPGTQ VDLPGLSEQD VQDLRFGVEH GVDIVFVSFV RKASDVAAVR
260 270 280 290 300
DALGPEGQGI KIVSKIENHE GVKKFNEILE VSDGIMVARG DLGIEIPAEK
310 320 330 340 350
VFLAQKMMIG RCNLAGKPVV CATQMLESMI TKPRPTRAET SDVANAVLDG
360 370 380 390 400
ADCIMLSGET AKGNFPVEAV KMQHAIAREA EAAVYHRQLF EELRRAAPLS
410 420 430 440 450
RDPTEVTAIG AVEAAFKCCA GAIIVLTTTG RSAQLLSRYR PRATVIAVTR
460 470 480 490 500
SAQAARQAHL CRGVFPVLYR EPPEDIWADD VDRRVQFGID NGKLCGFLSS
510 520
GDLVIVVTGW QPGSGHTNIM RVLSVT
Length:526
Mass (Da):56,870
Last modified:June 13, 2006 - v1
Checksum:iAC685AAF5812710E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02007155 Genomic DNA. No translation available.
BT025386 mRNA. Translation: ABF57342.1.
RefSeqiNP_001069644.1. NM_001076176.1.
UniGeneiBt.61163.

Genome annotation databases

EnsembliENSBTAT00000046947; ENSBTAP00000044193; ENSBTAG00000017056.
GeneIDi539579.
KEGGibta:539579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02007155 Genomic DNA. No translation available.
BT025386 mRNA. Translation: ABF57342.1.
RefSeqiNP_001069644.1. NM_001076176.1.
UniGeneiBt.61163.

3D structure databases

SMRiQ1JPG7. Positions 9-525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046947; ENSBTAP00000044193; ENSBTAG00000017056.
GeneIDi539579.
KEGGibta:539579.

Organism-specific databases

CTDi5313.

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
HOVERGENiHBG000941.
KOiK12406.
OMAiPFERSED.
OrthoDBiEOG091G0597.
TreeFamiTF300390.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
ReactomeiR-BTA-70171. Glycolysis.
SABIO-RKQ1JPG7.

Gene expression databases

BgeeiENSBTAG00000017056.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ1JPG7_BOVIN
AccessioniPrimary (citable) accession number: Q1JPG7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.