Q1JPA6 (ARY1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase 1
EC=2.3.1.5

Alternative name(s):
Arylamide acetylase 1
N-acetyltransferase type 1
Short name=NAT-1

Gene names

Name:

NAT1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs By similarity.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Arylamine N-acetyltransferase 1		PRO_0000284078
Regions
	Region	106 – 107	2	Substrate binding By similarity
Sites
	Binding site	103	1	Coenzyme A By similarity
	Binding site	208	1	Coenzyme A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1JPA6 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 72E4A2B7C0F70F4C	FASTA	290	34,199
	10 20 30 40 50 60 MDIDAYFERI GYKNSRDKLD LETLTDILQH QIRAIPFENL NIHCGEAMEL DLEVIFDQIV 70 80 90 100 110 120 RRKRGGWCLQ VNHLLYWALT MIGFETTILG GYVYNTFNDK YSSAMIHLLL KVTIDGRDYI 130 140 150 160 170 180 ADAGFGRSYQ MWQPLELISG KYQPQTPCIF RLTEDRGTWY LDQIRREQYI PNQDFLDSDL 190 200 210 220 230 240 LEKNEYRKIY SFTLEPRTIK DFESVNTYLQ ESPASVFTSK SFCSLQTPEG VHCLVGFTLT 250 260 270 280 290 YRRFNYKDNT DLVEFKTLNE KEIEENLKNI FNISLEKKLT PKHGDKFFTI

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT025447 mRNA. Translation: ABF57403.1. BC123764 mRNA. Translation: AAI23765.1.
IPI	IPI00717141.
RefSeq	NP_001069040.1. NM_001075572.1.
UniGene	Bt.22638.
3D structure databases
ProteinModelPortal	Q1JPA6.
SMR	Q1JPA6. Positions 2-290.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JPA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000048506; ENSBTAP00000045530; ENSBTAG00000016473.
GeneID	512603.
KEGG	bta:512603.
Organism-specific databases
CTD	9.
Phylogenomic databases
eggNOG	maNOG10028.
GeneTree	ENSGT00390000012054.
HOVERGEN	HBG000165.
InParanoid	Q1JPA6.
OMA	DFESVNI.
OrthoDB	EOG46Q6T2.
PhylomeDB	Q1JPA6.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
KO	K00622.
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...

Entry information

Entry name

ARY1_BOVIN

Accession

Primary (citable) accession number: Q1JPA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	June 13, 2006
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program