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Protein

Arylamine N-acetyltransferase 1

Gene

NAT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs.By similarity

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Coenzyme ABy similarity
Binding sitei208 – 2081Coenzyme ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-BTA-156582. Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 1
N-acetyltransferase type 1
Short name:
NAT-1
Gene namesi
Name:NAT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Arylamine N-acetyltransferase 1PRO_0000284078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ1JPA6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045530.

Structurei

3D structure databases

ProteinModelPortaliQ1JPA6.
SMRiQ1JPA6. Positions 2-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
GeneTreeiENSGT00390000012054.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiQ1JPA6.
KOiK00622.
OMAiPFENFDI.
OrthoDBiEOG7BP83H.
TreeFamiTF106311.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

Q1JPA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIDAYFERI GYKNSRDKLD LETLTDILQH QIRAIPFENL NIHCGEAMEL
60 70 80 90 100
DLEVIFDQIV RRKRGGWCLQ VNHLLYWALT MIGFETTILG GYVYNTFNDK
110 120 130 140 150
YSSAMIHLLL KVTIDGRDYI ADAGFGRSYQ MWQPLELISG KYQPQTPCIF
160 170 180 190 200
RLTEDRGTWY LDQIRREQYI PNQDFLDSDL LEKNEYRKIY SFTLEPRTIK
210 220 230 240 250
DFESVNTYLQ ESPASVFTSK SFCSLQTPEG VHCLVGFTLT YRRFNYKDNT
260 270 280 290
DLVEFKTLNE KEIEENLKNI FNISLEKKLT PKHGDKFFTI
Length:290
Mass (Da):34,199
Last modified:June 13, 2006 - v1
Checksum:i72E4A2B7C0F70F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025447 mRNA. Translation: ABF57403.1.
BC123764 mRNA. Translation: AAI23765.1.
RefSeqiNP_001069040.1. NM_001075572.1.
XP_005226217.1. XM_005226160.3.
XP_005226218.1. XM_005226161.3.
XP_005226219.1. XM_005226162.3.
XP_005226220.1. XM_005226163.3.
XP_005226221.1. XM_005226164.3.
XP_010818673.1. XM_010820371.2.
XP_010818674.1. XM_010820372.1.
UniGeneiBt.22638.

Genome annotation databases

EnsembliENSBTAT00000048506; ENSBTAP00000045530; ENSBTAG00000016473.
GeneIDi512603.
KEGGibta:512603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025447 mRNA. Translation: ABF57403.1.
BC123764 mRNA. Translation: AAI23765.1.
RefSeqiNP_001069040.1. NM_001075572.1.
XP_005226217.1. XM_005226160.3.
XP_005226218.1. XM_005226161.3.
XP_005226219.1. XM_005226162.3.
XP_005226220.1. XM_005226163.3.
XP_005226221.1. XM_005226164.3.
XP_010818673.1. XM_010820371.2.
XP_010818674.1. XM_010820372.1.
UniGeneiBt.22638.

3D structure databases

ProteinModelPortaliQ1JPA6.
SMRiQ1JPA6. Positions 2-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045530.

Proteomic databases

PaxDbiQ1JPA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000048506; ENSBTAP00000045530; ENSBTAG00000016473.
GeneIDi512603.
KEGGibta:512603.

Organism-specific databases

CTDi9.

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
GeneTreeiENSGT00390000012054.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiQ1JPA6.
KOiK00622.
OMAiPFENFDI.
OrthoDBiEOG7BP83H.
TreeFamiTF106311.

Enzyme and pathway databases

ReactomeiR-BTA-156582. Acetylation.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiARY1_BOVIN
AccessioniPrimary (citable) accession number: Q1JPA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.