ID   AL3B1_BOVIN             Reviewed;         468 AA.
AC   Q1JPA0; A6QLG7;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Aldehyde dehydrogenase family 3 member B1;
DE            EC=1.2.1.5;
GN   Name=ALDH3B1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = an acid +
CC       NAD(P)H.
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from
CC       ethanol: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; BT025453; ABF57409.1; -; mRNA.
DR   EMBL; BT026328; ABG81484.1; -; mRNA.
DR   EMBL; BC147958; AAI47959.1; -; mRNA.
DR   IPI; IPI00715333; -.
DR   RefSeq; NP_001068986.1; -.
DR   UniGene; Bt.62942; -.
DR   Ensembl; ENSBTAG00000013093; Bos taurus.
DR   GeneID; 511469; -.
DR   KEGG; bta:511469; -.
DR   HOVERGEN; Q1JPA0; -.
DR   BRENDA; 1.2.1.5; 251.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:EC.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   PANTHER; PTHR11699:SF15; ALDH; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase; Phosphoprotein.
FT   CHAIN         1    468       Aldehyde dehydrogenase family 3 member
FT                                B1.
FT                                /FTId=PRO_0000259960.
FT   NP_BIND     188    193       NAD (By similarity).
FT   ACT_SITE    210    210       By similarity.
FT   ACT_SITE    244    244       By similarity.
FT   MOD_RES     368    368       Phosphoserine (By similarity).
FT   CONFLICT     27     27       D -> A (in Ref. 2; AAI47959).
FT   CONFLICT     66     66       I -> T (in Ref. 2; AAI47959).
SQ   SEQUENCE   468 AA;  51800 MW;  7D14AF7895810ED8 CRC64;
     MDPFADTLQR LREAFVSGRT RPAEFRDAQL KGLSRFLREN KQLLQEALAQ DLHKSAFEAE
     VSEISISQNE INLALRNLRT WMKDEKVSKN LATQLDSAFI RKEPFGLVLI LSPWNYPLNL
     SLGPLVGALA AGNCVVLKPS EISKNTEKVL AEVLPRYLDQ SCFAVVLGGP QETGRLLEHK
     FDYIFFTGNP QVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAFFRCFNA
     GQTCVAPDYV LCSPEMQAQL VPALQSAITR FYGDDPQSSP NLGRIISQKH FQRLRGLLSC
     GRVVIGGQSD ECDLYIAPTV LVDVQETDPV MQEEIFGPIL PIVNVRSLGQ AIDFINRREK
     PLALYAFSNS SQVVKRVLAQ TSSGGFCGND GFMHLTLASL PFGGVGSSGM GNYHGKFSFD
     TFSHHRACLL RRPGLEKIYA IRYPPHTPRN LRVLLMAMET RSCSCTLL
//