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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

ALDH3B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.By similarity

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase, mitochondrial (ALDH2), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101PROSITE-ProRule annotation
Active sitei244 – 2441PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi188 – 1936NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-BTA-1660661. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.5)
Gene namesi
Name:ALDH3B1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity

  • Note: Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Aldehyde dehydrogenase family 3 member B1PRO_0000259960Add
BLAST
Propeptidei466 – 4683Removed in mature formCuratedPRO_0000424192

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Lipidationi463 – 4631S-palmitoyl cysteineBy similarity
Modified residuei465 – 4651Cysteine methyl esterCurated
Lipidationi465 – 4651S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ1JPA0.
PeptideAtlasiQ1JPA0.
PRIDEiQ1JPA0.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042081.

Structurei

3D structure databases

ProteinModelPortaliQ1JPA0.
SMRiQ1JPA0. Positions 6-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiQ1JPA0.
KOiK00129.
OMAiEHKTRDL.
OrthoDBiEOG73RBB3.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1JPA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFADTLQR LREAFVSGRT RPAEFRDAQL KGLSRFLREN KQLLQEALAQ
60 70 80 90 100
DLHKSAFEAE VSEISISQNE INLALRNLRT WMKDEKVSKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI LSPWNYPLNL SLGPLVGALA AGNCVVLKPS EISKNTEKVL
160 170 180 190 200
AEVLPRYLDQ SCFAVVLGGP QETGRLLEHK FDYIFFTGNP QVGKIVMTAA
210 220 230 240 250
AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAFFRCFNA GQTCVAPDYV
260 270 280 290 300
LCSPEMQAQL VPALQSAITR FYGDDPQSSP NLGRIISQKH FQRLRGLLSC
310 320 330 340 350
GRVVIGGQSD ECDLYIAPTV LVDVQETDPV MQEEIFGPIL PIVNVRSLGQ
360 370 380 390 400
AIDFINRREK PLALYAFSNS SQVVKRVLAQ TSSGGFCGND GFMHLTLASL
410 420 430 440 450
PFGGVGSSGM GNYHGKFSFD TFSHHRACLL RRPGLEKIYA IRYPPHTPRN
460
LRVLLMAMET RSCSCTLL
Length:468
Mass (Da):51,800
Last modified:June 13, 2006 - v1
Checksum:i7D14AF7895810ED8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271D → A in AAI47959 (Ref. 2) Curated
Sequence conflicti66 – 661I → T in AAI47959 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025453 mRNA. Translation: ABF57409.1.
BT026328 mRNA. Translation: ABG81484.1.
BC147958 mRNA. Translation: AAI47959.1.
RefSeqiNP_001068986.1. NM_001075518.1.
XP_005227117.2. XM_005227060.3.
XP_005227118.1. XM_005227061.3.
XP_005227119.1. XM_005227062.3.
UniGeneiBt.111358.

Genome annotation databases

EnsembliENSBTAT00000017408; ENSBTAP00000017408; ENSBTAG00000013093.
ENSBTAT00000044598; ENSBTAP00000042081; ENSBTAG00000013093.
GeneIDi511469.
KEGGibta:511469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025453 mRNA. Translation: ABF57409.1.
BT026328 mRNA. Translation: ABG81484.1.
BC147958 mRNA. Translation: AAI47959.1.
RefSeqiNP_001068986.1. NM_001075518.1.
XP_005227117.2. XM_005227060.3.
XP_005227118.1. XM_005227061.3.
XP_005227119.1. XM_005227062.3.
UniGeneiBt.111358.

3D structure databases

ProteinModelPortaliQ1JPA0.
SMRiQ1JPA0. Positions 6-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042081.

Proteomic databases

PaxDbiQ1JPA0.
PeptideAtlasiQ1JPA0.
PRIDEiQ1JPA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017408; ENSBTAP00000017408; ENSBTAG00000013093.
ENSBTAT00000044598; ENSBTAP00000042081; ENSBTAG00000013093.
GeneIDi511469.
KEGGibta:511469.

Organism-specific databases

CTDi221.

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiQ1JPA0.
KOiK00129.
OMAiEHKTRDL.
OrthoDBiEOG73RBB3.
TreeFamiTF314264.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
ReactomeiR-BTA-1660661. Sphingolipid de novo biosynthesis.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiAL3B1_BOVIN
AccessioniPrimary (citable) accession number: Q1JPA0
Secondary accession number(s): A6QLG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.