Reviewed, UniProtKB/Swiss-Prot Q1JPA0 (AL3B1_BOVIN)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 3 member B1
    EC=1.2.1.5

Gene names

Name:

ALDH3B1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Oxidizes medium and long chain saturated and unsaturated aldehydes By similarity. Metabolizes also benzaldehyde By similarity. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde By similarity. May not metabolize short chain aldehydes By similarity. May use both NADP+ and NAD+ as cofactors By similarity. May have a protective role against the cytotoxicity induced by lipid peroxidation By similarity.
Catalytic activity	An aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Aldehyde dehydrogenase family 3 member B1		PRO_0000259960
Regions
	Nucleotide binding	188 – 193	6	NAD By similarity
Sites
	Active site	210	1	By similarity
	Active site	244	1	By similarity
Amino acid modifications
	Modified residue	368	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	27	1	D → A in AAI47959. Ref.2
	Sequence conflict	66	1	I → T in AAI47959. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q1JPA0-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 7D14AF7895810ED8	FASTA	468	51,800
	10 20 30 40 50 60 MDPFADTLQR LREAFVSGRT RPAEFRDAQL KGLSRFLREN KQLLQEALAQ DLHKSAFEAE 70 80 90 100 110 120 VSEISISQNE INLALRNLRT WMKDEKVSKN LATQLDSAFI RKEPFGLVLI LSPWNYPLNL 130 140 150 160 170 180 SLGPLVGALA AGNCVVLKPS EISKNTEKVL AEVLPRYLDQ SCFAVVLGGP QETGRLLEHK 190 200 210 220 230 240 FDYIFFTGNP QVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAFFRCFNA 250 260 270 280 290 300 GQTCVAPDYV LCSPEMQAQL VPALQSAITR FYGDDPQSSP NLGRIISQKH FQRLRGLLSC 310 320 330 340 350 360 GRVVIGGQSD ECDLYIAPTV LVDVQETDPV MQEEIFGPIL PIVNVRSLGQ AIDFINRREK 370 380 390 400 410 420 PLALYAFSNS SQVVKRVLAQ TSSGGFCGND GFMHLTLASL PFGGVGSSGM GNYHGKFSFD 430 440 450 460 TFSHHRACLL RRPGLEKIYA IRYPPHTPRN LRVLLMAMET RSCSCTLL

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT025453 mRNA. Translation: ABF57409.1. BT026328 mRNA. Translation: ABG81484.1. BC147958 mRNA. Translation: AAI47959.1.
IPI	IPI00715333.
RefSeq	NP_001068986.1.
UniGene	Bt.62942
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000016003; ENSBTAP00000016003; ENSBTAG00000013093; Bos taurus. [Genome view]
GeneID	511469.
KEGG	bta:511469.
Organism-specific databases
CTD	511469.
Phylogenomic databases
HOVERGEN	Q1JPA0.
Enzyme and pathway databases
BRENDA	1.2.1.5. 251.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR012394. Aldehyde_DH_NAD(P). [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL3B1_BOVIN

Accession

Primary (citable) accession number: Q1JPA0
Secondary accession number(s): A6QLG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2006
Last sequence update:	June 13, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)