Reviewed, UniProtKB/Swiss-Prot Q1JP75 (DCXR_BOVIN)

Names and origin

Protein names

Recommended name:
    L-xylulose reductase
      Short name=XR
    EC=1.1.1.10
Alternative name(s):
    Dicarbonyl/L-xylulose reductase

Gene names

Name:

DCXR

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules By similarity.
Catalytic activity	Xylitol + NADP+ = L-xylulose + NADPH.
Subunit structure	Homotetramer By similarity.
Subcellular location	Membrane; Peripheral membrane protein By similarity. Note: Probably recruited to membranes via an interaction with phosphatidylinositol By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism Xylose metabolism
Cellular component	Membrane
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-xylulose reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	L-xylulose reductase		PRO_0000259351
Regions
	Nucleotide binding	11 – 39	29	NADP By similarity
Sites
	Active site	149	1	Proton acceptor By similarity
	Active site	153	1	By similarity
	Binding site	136	1	Substrate By similarity
Amino acid modifications
	Modified residue	149	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1JP75-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: DFDB13119181BA6E	FASTA	244	25,650
	10 20 30 40 50 60 MDLRLAGRRA LVTGAGKGIG RSIVKALHAA GARVVAVSRT QADLDSLVRE CPGVETVCVD 70 80 90 100 110 120 LADWEATEQA LGGVGPVDLL VNNAAVAFLQ PFLEVTKEAY DMSFSVNLRA VIQVSQIVAR 130 140 150 160 170 180 GLIARGAPGV IVNVSSQASQ RGLTNHSVYC STKGALDTLT KVMAVELGPH KIRVNAVNPT 190 200 210 220 230 240 VVMTPMGQAA WSDPQKAKAM LDRIPLGRFA EVENVVDTIL FLLSDRSSMT TGSTVPVDGG FLAT

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT025479 mRNA. Translation: ABF57435.1.
IPI	IPI00685459.
RefSeq	NP_001069359.1. XP_001250628.1.
UniGene	Bt.3200
3D structure databases
SMR	Q1JP75. Positions 1-243.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000008747. Bos taurus. [Contig view]
GeneID	526937. 782391.
KEGG	bta:526937. bta:782391.
Phylogenomic databases
HOVERGEN	Q1JP75.
Enzyme and pathway databases
BRENDA	1.1.1.10. 251.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCXR_BOVIN

Accession

Primary (citable) accession number: Q1JP75

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 13, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)