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Protein

Synaptic vesicle 2-related protein

Gene

SVOP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle 2-related protein
Short name:
SV2-related protein
Gene namesi
Name:SVOP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 122VesicularSequence analysisAdd BLAST14
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 156CytoplasmicSequence analysisAdd BLAST13
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 180VesicularSequence analysis3
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 209CytoplasmicSequence analysis8
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 238VesicularSequence analysis8
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 316CytoplasmicSequence analysisAdd BLAST57
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 373VesicularSequence analysisAdd BLAST36
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 401CytoplasmicSequence analysis7
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 425VesicularSequence analysis3
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 457CytoplasmicSequence analysisAdd BLAST11
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 489VesicularSequence analysisAdd BLAST11
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 548CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794511 – 548Synaptic vesicle 2-related proteinAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1JP63.
PRIDEiQ1JP63.

Expressioni

Tissue specificityi

Detected in brain and adrenal medulla.1 Publication

Gene expression databases

BgeeiENSBTAG00000018833.
ExpressionAtlasiQ1JP63. differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029564.

Structurei

3D structure databases

ProteinModelPortaliQ1JP63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ1JP63.
OMAiKEDYMDL.
OrthoDBiEOG091G04VD.
TreeFamiTF313465.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1JP63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VRAGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK
410 420 430 440 450
KTMALCFVVF SFCSLLLFIC VGRNMLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRGLQES SHREWGQEMV GRGAHGTGVA RSNSGSQE
Length:548
Mass (Da):60,748
Last modified:June 13, 2006 - v1
Checksum:iB9EB7CC19206D813
GO
Isoform 2 (identifier: Q1JP63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-468: VYPTATRALGLGTCSGMA → LRSAQLSRALTLSHHPKS
     469-548: Missing.

Show »
Length:468
Mass (Da):52,544
Checksum:iBDC57923E07531DD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023442451 – 468VYPTA…CSGMA → LRSAQLSRALTLSHHPKS in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_023443469 – 548Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025491 mRNA. Translation: ABF57447.1.
BC118274 mRNA. Translation: AAI18275.1.
RefSeqiNP_001068909.1. NM_001075441.1. [Q1JP63-1]
UniGeneiBt.25377.

Genome annotation databases

EnsembliENSBTAT00000025070; ENSBTAP00000025070; ENSBTAG00000018833. [Q1JP63-2]
ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833. [Q1JP63-1]
GeneIDi510256.
KEGGibta:510256.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025491 mRNA. Translation: ABF57447.1.
BC118274 mRNA. Translation: AAI18275.1.
RefSeqiNP_001068909.1. NM_001075441.1. [Q1JP63-1]
UniGeneiBt.25377.

3D structure databases

ProteinModelPortaliQ1JP63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029564.

Proteomic databases

PaxDbiQ1JP63.
PRIDEiQ1JP63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025070; ENSBTAP00000025070; ENSBTAG00000018833. [Q1JP63-2]
ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833. [Q1JP63-1]
GeneIDi510256.
KEGGibta:510256.

Organism-specific databases

CTDi55530.

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ1JP63.
OMAiKEDYMDL.
OrthoDBiEOG091G04VD.
TreeFamiTF313465.

Gene expression databases

BgeeiENSBTAG00000018833.
ExpressionAtlasiQ1JP63. differential.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSVOP_BOVIN
AccessioniPrimary (citable) accession number: Q1JP63
Secondary accession number(s): Q17QM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.