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Protein

Synaptic vesicle 2-related protein

Gene

SVOP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle 2-related protein
Short name:
SV2-related protein
Gene namesi
Name:SVOP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 12214VesicularSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 15613CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 1803VesicularSequence analysis
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Topological domaini202 – 2098CytoplasmicSequence analysis
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Topological domaini231 – 2388VesicularSequence analysis
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 31657CytoplasmicSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Topological domaini338 – 37336VesicularSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 4017CytoplasmicSequence analysis
Transmembranei402 – 42221HelicalSequence analysisAdd
BLAST
Topological domaini423 – 4253VesicularSequence analysis
Transmembranei426 – 44621HelicalSequence analysisAdd
BLAST
Topological domaini447 – 45711CytoplasmicSequence analysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence analysisAdd
BLAST
Topological domaini479 – 48911VesicularSequence analysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence analysisAdd
BLAST
Topological domaini511 – 54838CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Synaptic vesicle 2-related proteinPRO_0000279451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei542 – 5421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1JP63.
PRIDEiQ1JP63.

Expressioni

Tissue specificityi

Detected in brain and adrenal medulla.1 Publication

Gene expression databases

BgeeiENSBTAG00000018833.
ExpressionAtlasiQ1JP63. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029564.

Structurei

3D structure databases

ProteinModelPortaliQ1JP63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ1JP63.
OMAiKEDYMDL.
OrthoDBiEOG091G04VD.
TreeFamiTF313465.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1JP63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VRAGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK
410 420 430 440 450
KTMALCFVVF SFCSLLLFIC VGRNMLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRGLQES SHREWGQEMV GRGAHGTGVA RSNSGSQE
Length:548
Mass (Da):60,748
Last modified:June 13, 2006 - v1
Checksum:iB9EB7CC19206D813
GO
Isoform 2 (identifier: Q1JP63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-468: VYPTATRALGLGTCSGMA → LRSAQLSRALTLSHHPKS
     469-548: Missing.

Show »
Length:468
Mass (Da):52,544
Checksum:iBDC57923E07531DD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei451 – 46818VYPTA…CSGMA → LRSAQLSRALTLSHHPKS in isoform 2. 1 PublicationVSP_023442Add
BLAST
Alternative sequencei469 – 54880Missing in isoform 2. 1 PublicationVSP_023443Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025491 mRNA. Translation: ABF57447.1.
BC118274 mRNA. Translation: AAI18275.1.
RefSeqiNP_001068909.1. NM_001075441.1. [Q1JP63-1]
UniGeneiBt.25377.

Genome annotation databases

EnsembliENSBTAT00000025070; ENSBTAP00000025070; ENSBTAG00000018833. [Q1JP63-2]
ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833. [Q1JP63-1]
GeneIDi510256.
KEGGibta:510256.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025491 mRNA. Translation: ABF57447.1.
BC118274 mRNA. Translation: AAI18275.1.
RefSeqiNP_001068909.1. NM_001075441.1. [Q1JP63-1]
UniGeneiBt.25377.

3D structure databases

ProteinModelPortaliQ1JP63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029564.

Proteomic databases

PaxDbiQ1JP63.
PRIDEiQ1JP63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025070; ENSBTAP00000025070; ENSBTAG00000018833. [Q1JP63-2]
ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833. [Q1JP63-1]
GeneIDi510256.
KEGGibta:510256.

Organism-specific databases

CTDi55530.

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ1JP63.
OMAiKEDYMDL.
OrthoDBiEOG091G04VD.
TreeFamiTF313465.

Gene expression databases

BgeeiENSBTAG00000018833.
ExpressionAtlasiQ1JP63. baseline.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSVOP_BOVIN
AccessioniPrimary (citable) accession number: Q1JP63
Secondary accession number(s): Q17QM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.