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Protein

Lysine-specific demethylase 8

Gene

KDM8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1).By similarity

Catalytic activityi

Protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O2 = protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO2.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi311Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi313Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi390Iron; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processCell cycle, Transcription, Transcription regulation
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase 8 (EC:1.14.11.27)
Alternative name(s):
JmjC domain-containing protein 5
Jumonji domain-containing protein 5
Gene namesi
Name:KDM8
Synonyms:JMJD5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920091 – 406Lysine-specific demethylase 8Add BLAST406

Proteomic databases

PaxDbiQ1JP61.
PRIDEiQ1JP61.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019530.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026023.

Structurei

3D structure databases

SMRiQ1JP61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini261 – 406JmjCPROSITE-ProRule annotationAdd BLAST146

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOVERGENiHBG105493.
InParanoidiQ1JP61.
KOiK10277.
OMAiQNFLVQV.
OrthoDBiEOG091G069K.
TreeFamiTF315056.

Family and domain databases

InterProiView protein in InterPro
IPR003347. JmjC_dom.
SMARTiView protein in SMART
SM00558. JmjC. 1 hit.
PROSITEiView protein in PROSITE
PS51184. JMJC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JP61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPSTLWET LQALLPHTKE ELKLELGEKV EGSVLMLLQE AAELFLGGQR
60 70 80 90 100
RECLQTCEVL LDYSWEKLNT GPWQHVDKDW RRVYAFGCLL KAVCLCEPPG
110 120 130 140 150
DAASVAAALK ACDMGLLMGA AILGDILLKV AAVLQKYLLS GKRPAPGPSQ
160 170 180 190 200
EPPGTKKARN DHVPIPDVTT ERTVPRLHCP SLQYFKKHFL VPGRPVILEG
210 220 230 240 250
VANHWPCMKK WSLEYIQEVA GCRTVPVEVG SRYTDEEWSQ TLMTVNEFIS
260 270 280 290 300
KYIREEPKDI GYLAQHQLFD QIPELKQDIS IPDYCCLGDG EEEEITINAW
310 320 330 340 350
FGPQGTVSPL HQDPQQNFLA QVMGRKYIRL YSPQESEALY PHDTHLLHNT
360 370 380 390 400
SQVDVENPDL EKFPRFAEAP FLSCVLSPGE VLFIPVKHWH YVRALDLSFS

VSFWWS
Length:406
Mass (Da):45,907
Last modified:June 13, 2006 - v1
Checksum:iD6A5A5078715E196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025493 mRNA. Translation: ABF57449.1.
BC123879 mRNA. Translation: AAI23880.1.
RefSeqiNP_001068807.1. NM_001075339.1.
UniGeneiBt.45836.

Genome annotation databases

EnsembliENSBTAT00000026023; ENSBTAP00000026023; ENSBTAG00000019530.
GeneIDi507905.
KEGGibta:507905.

Similar proteinsi

Entry informationi

Entry nameiKDM8_BOVIN
AccessioniPrimary (citable) accession number: Q1JP61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 13, 2006
Last modified: September 27, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome