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Protein

Lysine-specific demethylase 8

Gene

KDM8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1) (By similarity).By similarity

Catalytic activityi

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.
Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi311 – 3111Iron; catalyticPROSITE-ProRule annotation
Metal bindingi313 – 3131Iron; catalyticPROSITE-ProRule annotation
Metal bindingi390 – 3901Iron; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase 8 (EC:1.14.11.27)
Alternative name(s):
JmjC domain-containing protein 5
Jumonji domain-containing protein 5
Gene namesi
Name:KDM8
Synonyms:JMJD5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Lysine-specific demethylase 8PRO_0000292009Add
BLAST

Proteomic databases

PaxDbiQ1JP61.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026023.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini261 – 406146JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOVERGENiHBG105493.
InParanoidiQ1JP61.
KOiK10277.
OMAiYSMACLH.
OrthoDBiEOG7KWSJQ.
TreeFamiTF315056.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JP61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPSTLWET LQALLPHTKE ELKLELGEKV EGSVLMLLQE AAELFLGGQR
60 70 80 90 100
RECLQTCEVL LDYSWEKLNT GPWQHVDKDW RRVYAFGCLL KAVCLCEPPG
110 120 130 140 150
DAASVAAALK ACDMGLLMGA AILGDILLKV AAVLQKYLLS GKRPAPGPSQ
160 170 180 190 200
EPPGTKKARN DHVPIPDVTT ERTVPRLHCP SLQYFKKHFL VPGRPVILEG
210 220 230 240 250
VANHWPCMKK WSLEYIQEVA GCRTVPVEVG SRYTDEEWSQ TLMTVNEFIS
260 270 280 290 300
KYIREEPKDI GYLAQHQLFD QIPELKQDIS IPDYCCLGDG EEEEITINAW
310 320 330 340 350
FGPQGTVSPL HQDPQQNFLA QVMGRKYIRL YSPQESEALY PHDTHLLHNT
360 370 380 390 400
SQVDVENPDL EKFPRFAEAP FLSCVLSPGE VLFIPVKHWH YVRALDLSFS

VSFWWS
Length:406
Mass (Da):45,907
Last modified:June 13, 2006 - v1
Checksum:iD6A5A5078715E196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025493 mRNA. Translation: ABF57449.1.
BC123879 mRNA. Translation: AAI23880.1.
RefSeqiNP_001068807.1. NM_001075339.1.
UniGeneiBt.45836.

Genome annotation databases

EnsembliENSBTAT00000026023; ENSBTAP00000026023; ENSBTAG00000019530.
GeneIDi507905.
KEGGibta:507905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025493 mRNA. Translation: ABF57449.1.
BC123879 mRNA. Translation: AAI23880.1.
RefSeqiNP_001068807.1. NM_001075339.1.
UniGeneiBt.45836.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026023.

Proteomic databases

PaxDbiQ1JP61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026023; ENSBTAP00000026023; ENSBTAG00000019530.
GeneIDi507905.
KEGGibta:507905.

Organism-specific databases

CTDi79831.

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOVERGENiHBG105493.
InParanoidiQ1JP61.
KOiK10277.
OMAiYSMACLH.
OrthoDBiEOG7KWSJQ.
TreeFamiTF315056.

Miscellaneous databases

NextBioi20868267.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiKDM8_BOVIN
AccessioniPrimary (citable) accession number: Q1JP61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 13, 2006
Last modified: November 11, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.