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Q1JP59

- Q1JP59_STRPC

UniProt

Q1JP59 - Q1JP59_STRPC

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Protein

DNA polymerase III subunit beta

Gene

dnaN

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotationSAAS annotation

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: InterPro
  3. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseUniRule annotationSAAS annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replicationUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSPYO370551:GHLY-2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit betaUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:dnaNImported
Ordered Locus Names:MGAS9429_Spy0002Imported
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)Imported
Taxonomic identifieri370551 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002433: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. DNA polymerase III complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi370551.MGAS9429_Spy0002.

Structurei

3D structure databases

ProteinModelPortaliQ1JP59.
SMRiQ1JP59. Positions 1-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0592.
HOGENOMiHOG000071792.
KOiK02338.
OMAiSHEGRNN.
OrthoDBiEOG65J53F.

Family and domain databases

InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JP59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQFSINRTL FIHALNATKR AISTKNAIPI LSSIKIEVTS TGVTLTGSNG
60 70 80 90 100
QISIENTIPV SNENAGLLIT SPGAILLEAS FFINIISSLP DISINVKEIE
110 120 130 140 150
QHQVVLTSGK SEITLKGKDV DQYPRLQEVS TENPLILKTK LLKSIIAETA
160 170 180 190 200
FAASLQESRP ILTGVHIVLS NHKDFKAVAT DSHRMSQRLI TLDNTSADFD
210 220 230 240 250
VVIPSKSLRE FSAVFTDDIE TVEVFFSPSQ ILFRSEHISF YTRLLEGNYP
260 270 280 290 300
DTDRLLMTEF ETEVVFNTQS LRHAMERAFL ISNATQNGTV KLEITQNHIS
310 320 330 340 350
AHVNSPEVGK VNEDLDIVSQ SGSDLTISFN PTYLIESLKA IKSETVKIHF
360 370
LSPVRPFTLT PGDEEESFIQ LITPVRTN
Length:378
Mass (Da):41,855
Last modified:June 13, 2006 - v1
Checksum:i2B7791E598C8A86C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000259 Genomic DNA. Translation: ABF31190.1.
RefSeqiYP_595734.1. NC_008021.1.

Genome annotation databases

EnsemblBacteriaiABF31190; ABF31190; MGAS9429_Spy0002.
GeneIDi4061523.
KEGGispk:MGAS9429_Spy0002.
PATRICi19750900. VBIStrPyo37061_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000259 Genomic DNA. Translation: ABF31190.1 .
RefSeqi YP_595734.1. NC_008021.1.

3D structure databases

ProteinModelPortali Q1JP59.
SMRi Q1JP59. Positions 1-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370551.MGAS9429_Spy0002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF31190 ; ABF31190 ; MGAS9429_Spy0002 .
GeneIDi 4061523.
KEGGi spk:MGAS9429_Spy0002.
PATRICi 19750900. VBIStrPyo37061_0002.

Phylogenomic databases

eggNOGi COG0592.
HOGENOMi HOG000071792.
KOi K02338.
OMAi SHEGRNN.
OrthoDBi EOG65J53F.

Enzyme and pathway databases

BioCyci SPYO370551:GHLY-2-MONOMER.

Family and domain databases

InterProi IPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view ]
Pfami PF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000804. DNA_pol_III_b. 1 hit.
SMARTi SM00480. POL3Bc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00663. dnan. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS9429Imported.

Entry informationi

Entry nameiQ1JP59_STRPC
AccessioniPrimary (citable) accession number: Q1JP59
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3