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Q1JP59

- Q1JP59_STRPC

UniProt

Q1JP59 - Q1JP59_STRPC

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Protein
DNA polymerase III subunit beta
Gene
dnaN, MGAS9429_Spy0002
Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA By similarity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotationSAAS annotations

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: InterPro
  3. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    DNA-directed DNA polymeraseUniRule annotationSAAS annotations, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replicationUniRule annotationSAAS annotations

    Enzyme and pathway databases

    BioCyciSPYO370551:GHLY-2-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit betaUniRule annotation (EC:2.7.7.7UniRule annotation)
    Gene namesi
    Name:dnaNImported
    Ordered Locus Names:MGAS9429_Spy0002Imported
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)Imported
    Taxonomic identifieri370551 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002433: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotationSAAS annotations

    GO - Cellular componenti

    1. DNA polymerase III complex Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotations

    Interactioni

    Protein-protein interaction databases

    STRINGi370551.MGAS9429_Spy0002.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JP59.
    SMRiQ1JP59. Positions 1-377.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0592.
    HOGENOMiHOG000071792.
    KOiK02338.
    OMAiSHEGRNN.
    OrthoDBiEOG65J53F.

    Family and domain databases

    InterProiIPR001001. DNA_polIII_beta.
    IPR022635. DNA_polIII_beta_C.
    IPR022637. DNA_polIII_beta_cen.
    IPR022634. DNA_polIII_beta_N.
    [Graphical view]
    PfamiPF00712. DNA_pol3_beta. 1 hit.
    PF02767. DNA_pol3_beta_2. 1 hit.
    PF02768. DNA_pol3_beta_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
    SMARTiSM00480. POL3Bc. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00663. dnan. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1JP59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQFSINRTL FIHALNATKR AISTKNAIPI LSSIKIEVTS TGVTLTGSNG    50
    QISIENTIPV SNENAGLLIT SPGAILLEAS FFINIISSLP DISINVKEIE 100
    QHQVVLTSGK SEITLKGKDV DQYPRLQEVS TENPLILKTK LLKSIIAETA 150
    FAASLQESRP ILTGVHIVLS NHKDFKAVAT DSHRMSQRLI TLDNTSADFD 200
    VVIPSKSLRE FSAVFTDDIE TVEVFFSPSQ ILFRSEHISF YTRLLEGNYP 250
    DTDRLLMTEF ETEVVFNTQS LRHAMERAFL ISNATQNGTV KLEITQNHIS 300
    AHVNSPEVGK VNEDLDIVSQ SGSDLTISFN PTYLIESLKA IKSETVKIHF 350
    LSPVRPFTLT PGDEEESFIQ LITPVRTN 378
    Length:378
    Mass (Da):41,855
    Last modified:June 13, 2006 - v1
    Checksum:i2B7791E598C8A86C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000259 Genomic DNA. Translation: ABF31190.1.
    RefSeqiYP_595734.1. NC_008021.1.

    Genome annotation databases

    EnsemblBacteriaiABF31190; ABF31190; MGAS9429_Spy0002.
    GeneIDi4061523.
    KEGGispk:MGAS9429_Spy0002.
    PATRICi19750900. VBIStrPyo37061_0002.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000259 Genomic DNA. Translation: ABF31190.1 .
    RefSeqi YP_595734.1. NC_008021.1.

    3D structure databases

    ProteinModelPortali Q1JP59.
    SMRi Q1JP59. Positions 1-377.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 370551.MGAS9429_Spy0002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF31190 ; ABF31190 ; MGAS9429_Spy0002 .
    GeneIDi 4061523.
    KEGGi spk:MGAS9429_Spy0002.
    PATRICi 19750900. VBIStrPyo37061_0002.

    Phylogenomic databases

    eggNOGi COG0592.
    HOGENOMi HOG000071792.
    KOi K02338.
    OMAi SHEGRNN.
    OrthoDBi EOG65J53F.

    Enzyme and pathway databases

    BioCyci SPYO370551:GHLY-2-MONOMER.

    Family and domain databases

    InterProi IPR001001. DNA_polIII_beta.
    IPR022635. DNA_polIII_beta_C.
    IPR022637. DNA_polIII_beta_cen.
    IPR022634. DNA_polIII_beta_N.
    [Graphical view ]
    Pfami PF00712. DNA_pol3_beta. 1 hit.
    PF02767. DNA_pol3_beta_2. 1 hit.
    PF02768. DNA_pol3_beta_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000804. DNA_pol_III_b. 1 hit.
    SMARTi SM00480. POL3Bc. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00663. dnan. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS9429Imported.

    Entry informationi

    Entry nameiQ1JP59_STRPC
    AccessioniPrimary (citable) accession number: Q1JP59
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: May 14, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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