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Protein

Beta sliding clamp

Gene

dnaN

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, DNA-directed DNA polymeraseUniRule annotationSAAS annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta sliding clampUniRule annotation
Gene namesi
Name:dnaNImported
Ordered Locus Names:MGAS9429_Spy0002Imported
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)Imported
Taxonomic identifieri370551 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002433 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a ring-shaped head-to-tail homodimer around DNA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JP59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 126DNA_pol3_betaInterPro annotationAdd BLAST124
Domaini137 – 251DNA_pol3_beta_2InterPro annotationAdd BLAST115
Domaini254 – 375DNA_pol3_beta_3InterPro annotationAdd BLAST122

Sequence similaritiesi

Belongs to the beta sliding clamp family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000071792.
KOiK02338.
OMAiNYEAVIP.

Family and domain databases

CDDicd00140. beta_clamp. 1 hit.
InterProiView protein in InterPro
IPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
PANTHERiPTHR30478. PTHR30478. 1 hit.
PfamiView protein in Pfam
PF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiView protein in SMART
SM00480. POL3Bc. 1 hit.
TIGRFAMsiTIGR00663. dnan. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JP59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFSINRTL FIHALNATKR AISTKNAIPI LSSIKIEVTS TGVTLTGSNG
60 70 80 90 100
QISIENTIPV SNENAGLLIT SPGAILLEAS FFINIISSLP DISINVKEIE
110 120 130 140 150
QHQVVLTSGK SEITLKGKDV DQYPRLQEVS TENPLILKTK LLKSIIAETA
160 170 180 190 200
FAASLQESRP ILTGVHIVLS NHKDFKAVAT DSHRMSQRLI TLDNTSADFD
210 220 230 240 250
VVIPSKSLRE FSAVFTDDIE TVEVFFSPSQ ILFRSEHISF YTRLLEGNYP
260 270 280 290 300
DTDRLLMTEF ETEVVFNTQS LRHAMERAFL ISNATQNGTV KLEITQNHIS
310 320 330 340 350
AHVNSPEVGK VNEDLDIVSQ SGSDLTISFN PTYLIESLKA IKSETVKIHF
360 370
LSPVRPFTLT PGDEEESFIQ LITPVRTN
Length:378
Mass (Da):41,855
Last modified:June 13, 2006 - v1
Checksum:i2B7791E598C8A86C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000259 Genomic DNA. Translation: ABF31190.1.
RefSeqiWP_002987661.1. NC_008021.1.

Genome annotation databases

EnsemblBacteriaiABF31190; ABF31190; MGAS9429_Spy0002.
KEGGispk:MGAS9429_Spy0002.

Similar proteinsi

Entry informationi

Entry nameiQ1JP59_STRPC
AccessioniPrimary (citable) accession number: Q1JP59
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: January 31, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported