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Protein

DNA polymerase III subunit beta

Gene

dnaN

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseUniRule annotationSAAS annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replicationUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSPYO370551:GHLY-2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit betaUniRule annotationSAAS annotation (EC:2.7.7.7UniRule annotationSAAS annotation)
Gene namesi
Name:dnaNImported
Ordered Locus Names:MGAS9429_Spy0002Imported
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)Imported
Taxonomic identifieri370551 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002433 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JP59.
SMRiQ1JP59. Positions 1-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 126124DNA_pol3_betaInterPro annotationAdd
BLAST
Domaini137 – 251115DNA_pol3_beta_2InterPro annotationAdd
BLAST
Domaini254 – 375122DNA_pol3_beta_3InterPro annotationAdd
BLAST

Phylogenomic databases

HOGENOMiHOG000071792.
KOiK02338.
OMAiTHQIRLK.

Family and domain databases

CDDicd00140. beta_clamp. 1 hit.
InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JP59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFSINRTL FIHALNATKR AISTKNAIPI LSSIKIEVTS TGVTLTGSNG
60 70 80 90 100
QISIENTIPV SNENAGLLIT SPGAILLEAS FFINIISSLP DISINVKEIE
110 120 130 140 150
QHQVVLTSGK SEITLKGKDV DQYPRLQEVS TENPLILKTK LLKSIIAETA
160 170 180 190 200
FAASLQESRP ILTGVHIVLS NHKDFKAVAT DSHRMSQRLI TLDNTSADFD
210 220 230 240 250
VVIPSKSLRE FSAVFTDDIE TVEVFFSPSQ ILFRSEHISF YTRLLEGNYP
260 270 280 290 300
DTDRLLMTEF ETEVVFNTQS LRHAMERAFL ISNATQNGTV KLEITQNHIS
310 320 330 340 350
AHVNSPEVGK VNEDLDIVSQ SGSDLTISFN PTYLIESLKA IKSETVKIHF
360 370
LSPVRPFTLT PGDEEESFIQ LITPVRTN
Length:378
Mass (Da):41,855
Last modified:June 13, 2006 - v1
Checksum:i2B7791E598C8A86C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000259 Genomic DNA. Translation: ABF31190.1.
RefSeqiWP_002987661.1. NC_008021.1.

Genome annotation databases

EnsemblBacteriaiABF31190; ABF31190; MGAS9429_Spy0002.
KEGGispk:MGAS9429_Spy0002.
PATRICi19750900. VBIStrPyo37061_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000259 Genomic DNA. Translation: ABF31190.1.
RefSeqiWP_002987661.1. NC_008021.1.

3D structure databases

ProteinModelPortaliQ1JP59.
SMRiQ1JP59. Positions 1-377.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF31190; ABF31190; MGAS9429_Spy0002.
KEGGispk:MGAS9429_Spy0002.
PATRICi19750900. VBIStrPyo37061_0002.

Phylogenomic databases

HOGENOMiHOG000071792.
KOiK02338.
OMAiTHQIRLK.

Enzyme and pathway databases

BioCyciSPYO370551:GHLY-2-MONOMER.

Family and domain databases

CDDicd00140. beta_clamp. 1 hit.
InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ1JP59_STRPC
AccessioniPrimary (citable) accession number: Q1JP59
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.