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Q1JNM4 (G6PI_STRPC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:MGAS9429_Spy0187
OrganismStreptococcus pyogenes serotype M12 (strain MGAS9429) [Complete proteome] [HAMAP]
Taxonomic identifier370551 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000252651

Sites

Active site2911Proton donor By similarity
Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1JNM4 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 37290F634E7E03EA

FASTA44949,497
        10         20         30         40         50         60 
MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD LPENYDKEEF 

        70         80         90        100        110        120 
ARILTAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNHHF ANLQTAKERK APQILYAGNS 

       130        140        150        160        170        180 
ISSTYLADLV EYVQDKEFSV NVISKSGTTT EPAIAFRVFK ELLVKKYGQE EANKRIYATT 

       190        200        210        220        230        240 
DKVKGAVKVE ADANNWETFV VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD 

       250        260        270        280        290        300 
LSSDKISENI AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 

       310        320        330        340        350        360 
YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDKPRKNVI IPELAEDLDG LGYLQGKDVD 

       370        380        390        400        410        420 
FVNKKATDGV LLAHTDGGVP NMFVTLPAQD EFTLGYTIYF FELAIAVSGY MNAVNPFDQP 

       430        440 
GVEAYKRNMF ALLGKPGFEA LSAELNARL 

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References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS9429.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000259 Genomic DNA. Translation: ABF31375.1.
RefSeqYP_595919.1. NC_008021.1.

3D structure databases

ProteinModelPortalQ1JNM4.
SMRQ1JNM4. Positions 3-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370551.MGAS9429_Spy0187.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF31375; ABF31375; MGAS9429_Spy0187.
GeneID4062248.
KEGGspk:MGAS9429_Spy0187.
PATRIC19751374. VBIStrPyo37061_0189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OMAEPSLHFV.
OrthoDBEOG64R61J.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycSPYO370551:GHLY-237-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_STRPC
AccessionPrimary (citable) accession number: Q1JNM4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 13, 2006
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways