ID   NANE_STRPC              Reviewed;         234 AA.
AC   Q1JNJ8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase;
GN   Name=nanE; OrderedLocusNames=MGAS9429_Spy0213;
OS   Streptococcus pyogenes serotype M12 (strain MGAS9429).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370551;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F.,
RA   DeLeo F.R., Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in
RT   the human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to
CC       N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (Potential).
CC   -!- CATALYTIC ACTIVITY: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 3/5.
CC   -!- SIMILARITY: Belongs to the nanE family.
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DR   EMBL; CP000259; ABF31401.1; -; Genomic_DNA.
DR   RefSeq; YP_595945.1; -.
DR   GeneID; 4061280; -.
DR   GenomeReviews; CP000259_GR; MGAS9429_Spy0213.
DR   KEGG; spk:MGAS9429_Spy0213; -.
DR   HOGENOM; Q1JNJ8; -.
DR   OMA; Q1JNJ8; EAGPDMA.
DR   BioCyc; SPYO370551:MGAS9429_SPY0213-MON; -.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase a...; IEA:EC.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01235; -; 1.
DR   InterPro; IPR007260; NanE.
DR   Pfam; PF04131; NanE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase.
FT   CHAIN         1    234       Putative N-acetylmannosamine-6-phosphate
FT                                2-epimerase.
FT                                /FTId=PRO_0000301491.
SQ   SEQUENCE   234 AA;  25018 MW;  64F230DC26276F20 CRC64;
     MPDKPTKEKL MEQLKGGIIV SCQALPGEPL YSETGGIMPL LAKAAQEAGA VGIRANSVRD
     IKEIQAITDL PIIGIIKKDY PPQEPFITAT MAEVDQLAAL NIAVIAMDCT KRDRHDGLDI
     ASFIRQVKEK YPNQLLMADI STFDEGLVAH QAGIDFVGTT LSGYTPYSRQ EAGPDVALIE
     ALCKAGIAVI AEGKIHSPEE AKKINDLGVA GIVVGGAITR PKEIAERFIE ALKS
//