Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:MGAS9429_Spy0694
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)
Taxonomic identifieri370551 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002433 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000538711 – 173Bifunctional protein PyrRAdd BLAST173

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JMD0.
SMRiQ1JMD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi93 – 105PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245770.
KOiK02825.
OMAiRISHEIL.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiView protein in InterPro
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JMD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKEIVDDV TMKRAITRIT YEIIERNKQL DNVVLAGIKT RGVFLARRIQ
60 70 80 90 100
ERLHQLEGLD LPIGELDIKP FRDDMRVEED TTLMSVDITG KDVILIDDVL
110 120 130 140 150
YTGRTIRAAI DNLVSLGRPA RVSLAVLVDR GHRELPIRAD YVGKNIPTSS
160 170
VEEIVVEVVE VDGRDRVSII DPT
Length:173
Mass (Da):19,529
Last modified:June 13, 2006 - v1
Checksum:i1DCD30B002F6D8B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000259 Genomic DNA. Translation: ABF31882.1.
RefSeqiWP_002985093.1. NC_008021.1.

Genome annotation databases

EnsemblBacteriaiABF31882; ABF31882; MGAS9429_Spy0694.
KEGGispk:MGAS9429_Spy0694.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPYRR_STRPC
AccessioniPrimary (citable) accession number: Q1JMD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families