Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1JMD0

- PYRR_STRPC

UniProt

Q1JMD0 - PYRR_STRPC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-HAMAP
  2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciSPYO370551:GHLY-751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:MGAS9429_Spy0694
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)
Taxonomic identifieri370551 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002433: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Bifunctional protein PyrRPRO_1000053871Add
BLAST

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi370551.MGAS9429_Spy0694.

Structurei

3D structure databases

ProteinModelPortaliQ1JMD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi93 – 10513PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2065.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JMD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTKEIVDDV TMKRAITRIT YEIIERNKQL DNVVLAGIKT RGVFLARRIQ
60 70 80 90 100
ERLHQLEGLD LPIGELDIKP FRDDMRVEED TTLMSVDITG KDVILIDDVL
110 120 130 140 150
YTGRTIRAAI DNLVSLGRPA RVSLAVLVDR GHRELPIRAD YVGKNIPTSS
160 170
VEEIVVEVVE VDGRDRVSII DPT
Length:173
Mass (Da):19,529
Last modified:June 13, 2006 - v1
Checksum:i1DCD30B002F6D8B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000259 Genomic DNA. Translation: ABF31882.1.
RefSeqiYP_596426.1. NC_008021.1.

Genome annotation databases

EnsemblBacteriaiABF31882; ABF31882; MGAS9429_Spy0694.
GeneIDi4060568.
KEGGispk:MGAS9429_Spy0694.
PATRICi19752430. VBIStrPyo37061_0710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000259 Genomic DNA. Translation: ABF31882.1 .
RefSeqi YP_596426.1. NC_008021.1.

3D structure databases

ProteinModelPortali Q1JMD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370551.MGAS9429_Spy0694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF31882 ; ABF31882 ; MGAS9429_Spy0694 .
GeneIDi 4060568.
KEGGi spk:MGAS9429_Spy0694.
PATRICi 19752430. VBIStrPyo37061_0710.

Phylogenomic databases

eggNOGi COG2065.
HOGENOMi HOG000245770.
KOi K02825.
OMAi LMDMGRP.
OrthoDBi EOG61VZD8.

Enzyme and pathway databases

BioCyci SPYO370551:GHLY-751-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01219. PyrR.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS9429.

Entry informationi

Entry nameiPYRR_STRPC
AccessioniPrimary (citable) accession number: Q1JMD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3