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Q1JMD0

- PYRR_STRPC

UniProt

Q1JMD0 - PYRR_STRPC

Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
    Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-HAMAP
    2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. nucleoside metabolic process Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription termination

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciSPYO370551:GHLY-751-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein PyrRUniRule annotation
    Including the following 2 domains:
    Pyrimidine operon regulatory proteinUniRule annotation
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Short name:
    UPRTaseUniRule annotation
    Gene namesi
    Name:pyrRUniRule annotation
    Ordered Locus Names:MGAS9429_Spy0694
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)
    Taxonomic identifieri370551 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002433: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Bifunctional protein PyrRPRO_1000053871Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer and homohexamer; in equilibrium.UniRule annotation

    Protein-protein interaction databases

    STRINGi370551.MGAS9429_Spy0694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JMD0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi93 – 10513PRPP-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2065.
    HOGENOMiHOG000245770.
    KOiK02825.
    OMAiLMDMGRP.
    OrthoDBiEOG61VZD8.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01219. PyrR.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1JMD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTKEIVDDV TMKRAITRIT YEIIERNKQL DNVVLAGIKT RGVFLARRIQ    50
    ERLHQLEGLD LPIGELDIKP FRDDMRVEED TTLMSVDITG KDVILIDDVL 100
    YTGRTIRAAI DNLVSLGRPA RVSLAVLVDR GHRELPIRAD YVGKNIPTSS 150
    VEEIVVEVVE VDGRDRVSII DPT 173
    Length:173
    Mass (Da):19,529
    Last modified:June 13, 2006 - v1
    Checksum:i1DCD30B002F6D8B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000259 Genomic DNA. Translation: ABF31882.1.
    RefSeqiYP_596426.1. NC_008021.1.

    Genome annotation databases

    EnsemblBacteriaiABF31882; ABF31882; MGAS9429_Spy0694.
    GeneIDi4060568.
    KEGGispk:MGAS9429_Spy0694.
    PATRICi19752430. VBIStrPyo37061_0710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000259 Genomic DNA. Translation: ABF31882.1 .
    RefSeqi YP_596426.1. NC_008021.1.

    3D structure databases

    ProteinModelPortali Q1JMD0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370551.MGAS9429_Spy0694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF31882 ; ABF31882 ; MGAS9429_Spy0694 .
    GeneIDi 4060568.
    KEGGi spk:MGAS9429_Spy0694.
    PATRICi 19752430. VBIStrPyo37061_0710.

    Phylogenomic databases

    eggNOGi COG2065.
    HOGENOMi HOG000245770.
    KOi K02825.
    OMAi LMDMGRP.
    OrthoDBi EOG61VZD8.

    Enzyme and pathway databases

    BioCyci SPYO370551:GHLY-751-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01219. PyrR.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS9429.

    Entry informationi

    Entry nameiPYRR_STRPC
    AccessioniPrimary (citable) accession number: Q1JMD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3