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Q1JMD0 (PYRR_STRPC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein PyrR

Including the following 2 domains:

  1. Pyrimidine operon regulatory protein
  2. Uracil phosphoribosyltransferase
    Short name=UPRTase
    EC=2.4.2.9
Gene names
Name:pyrR
Ordered Locus Names:MGAS9429_Spy0694
OrganismStreptococcus pyogenes serotype M12 (strain MGAS9429) [Complete proteome] [HAMAP]
Taxonomic identifier370551 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes By similarity. HAMAP-Rule MF_01219

Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity. HAMAP-Rule MF_01219

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01219

Subunit structure

Homodimer and homohexamer; in equilibrium By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173Bifunctional protein PyrR HAMAP-Rule MF_01219
PRO_1000053871

Regions

Motif93 – 10513PRPP-binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1JMD0 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 1DCD30B002F6D8B3

FASTA17319,529
        10         20         30         40         50         60 
MKTKEIVDDV TMKRAITRIT YEIIERNKQL DNVVLAGIKT RGVFLARRIQ ERLHQLEGLD 

        70         80         90        100        110        120 
LPIGELDIKP FRDDMRVEED TTLMSVDITG KDVILIDDVL YTGRTIRAAI DNLVSLGRPA 

       130        140        150        160        170 
RVSLAVLVDR GHRELPIRAD YVGKNIPTSS VEEIVVEVVE VDGRDRVSII DPT 

« Hide

References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS9429.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000259 Genomic DNA. Translation: ABF31882.1.
RefSeqYP_596426.1. NC_008021.1.

3D structure databases

ProteinModelPortalQ1JMD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370551.MGAS9429_Spy0694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF31882; ABF31882; MGAS9429_Spy0694.
GeneID4060568.
KEGGspk:MGAS9429_Spy0694.
PATRIC19752430. VBIStrPyo37061_0710.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2065.
HOGENOMHOG000245770.
KOK02825.
OMARISHEIL.
OrthoDBEOG61VZD8.
ProtClustDBPRK05205.

Enzyme and pathway databases

BioCycSPYO370551:GHLY-751-MONOMER.

Family and domain databases

HAMAPMF_01219. PyrR.
InterProIPR000836. PRibTrfase_dom.
IPR023050. PyrR.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRR_STRPC
AccessionPrimary (citable) accession number: Q1JMD0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families