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Q1JLR5

- NADK_STRPC

UniProt

Q1JLR5 - NADK_STRPC

Protein

NAD kinase

Gene

nadK

Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Proton acceptorUniRule annotation
    Binding sitei159 – 1591NADUniRule annotation
    Binding sitei161 – 1611NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi57 – 582NADUniRule annotation
    Nucleotide bindingi133 – 1342NADUniRule annotation
    Nucleotide bindingi172 – 1776NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO370551:GHLY-1026-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:MGAS9429_Spy0967
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)
    Taxonomic identifieri370551 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002433: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279NAD kinasePRO_1000005449Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370551.MGAS9429_Spy0967.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JLR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiIQMSEIA.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1JLR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTQMNYTGK VKRVAIIANG KYQSKRVASK LFSVFKDDPD FYLSKKNPDI    50
    VISIGGDGML LSAFHMYEKE LDKVRFVGIH TGHLGFYTDY RDFEVDKLID 100
    NLRKDKGEQI SYPILKVAIT LDDGRVVKAR ALNEATVKRI EKTMVADVII 150
    NHVKFESFRG DGISVSTPTG STAYNKSLGG AVLHPTIEAL QLTEISSLNN 200
    RVFRTLGSSI IIPKKDKIEL VPKRLGIYTI SIDNKTYQLK NVTKVEYFID 250
    DEKIHFVSSP SHTSFWERVK DAFIGETDS 279
    Length:279
    Mass (Da):31,495
    Last modified:June 13, 2006 - v1
    Checksum:iEAC0FB7EC68B57A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000259 Genomic DNA. Translation: ABF32154.1.
    RefSeqiYP_596698.1. NC_008021.1.

    Genome annotation databases

    EnsemblBacteriaiABF32154; ABF32154; MGAS9429_Spy0967.
    GeneIDi4060554.
    KEGGispk:MGAS9429_Spy0967.
    PATRICi19752990. VBIStrPyo37061_0985.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000259 Genomic DNA. Translation: ABF32154.1 .
    RefSeqi YP_596698.1. NC_008021.1.

    3D structure databases

    ProteinModelPortali Q1JLR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370551.MGAS9429_Spy0967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF32154 ; ABF32154 ; MGAS9429_Spy0967 .
    GeneIDi 4060554.
    KEGGi spk:MGAS9429_Spy0967.
    PATRICi 19752990. VBIStrPyo37061_0985.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi IQMSEIA.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SPYO370551:GHLY-1026-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS9429.

    Entry informationi

    Entry nameiNADK_STRPC
    AccessioniPrimary (citable) accession number: Q1JLR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3