Q1JLB7 (DLTA_STRPC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1
EC=6.1.1.13

Alternative name(s):
D-alanine-D-alanyl carrier protein ligase
Short name=DCL
D-alanine-activating enzyme
Short name=DAE

Gene names

Name:	dltA
Ordered Locus Names:	MGAS9429_Spy1115

Organism

Streptococcus pyogenes serotype M12 (strain MGAS9429) [Complete proteome] [HAMAP]

Taxonomic identifier

370551 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp By similarity. HAMAP MF_00593
Catalytic activity	ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00593
Pathway	Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00593
Subcellular location	Cytoplasm Probable HAMAP MF_00593.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	D-alanine--poly(phosphoribitol) ligase subunit 1 HAMAP MF_00593		PRO_1000025537

Sequences

	Sequence		Length	Mass (Da)
	Q1JLB7 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 330928DC894A6146	FASTA	512	56,987
	10 20 30 40 50 60 MIKDMIDSIE QFAQTQADFP VYDCLGERRT YGQLKRDSDS IAAFIDSLAL LAKSPVLVFG 70 80 90 100 110 120 AQTYDMLATF VALTKSGHAY IPVDVHSAPE RILAIIEIAK PSLIIAIEEF PLTIEGISLV 130 140 150 160 170 180 SLSEIESAKL AEMPYERTHS VKGDDNYYII FTSGTTGQPK GVQISHDNLL SFTNWMIEDA 190 200 210 220 230 240 AFDVPKQPQM LAQPPYSFDL SVMYWAPTLA LGGTLFALPK ELVADFKQLF TTIAQLPVGI 250 260 270 280 290 300 WTSTPSFADM AMLSDDFCQA KMPALTHFYF DGEELTVSTA RKLFERFPSA KIINAYGPTE 310 320 330 340 350 360 ATVALSAIEI TREMVDNYTR LPIGYPKPDS PTYIIDEDGK ELSSGEQGEI IVTGPAVSKG 370 380 390 400 410 420 YLNNPEKTAE AFFTFKGQPA YHTGDIGSLT EDNILLYGGR LDFQIKYAGY RIELEDVSQQ 430 440 450 460 470 480 LNQSPMVASA VAVPRYNKEH KVQNLLAYIV VKDGVKERFD RELELTKAIK ASVKDHMMSY 490 500 510 MMPSKFLYRD SLPLTPNGKI DIKTLINEVN NR

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS9429.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000259 Genomic DNA. Translation: ABF32302.1.
RefSeq	YP_596846.1. NC_008021.1.
3D structure databases
ProteinModelPortal	Q1JLB7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JLB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000046114; EBSTRP00000044331; EBSTRG00000046106.
GeneID	4060473.
GenomeReviews	Gene locus MGAS9429_Spy1115 in contig CP000259_GR.
KEGG	spk:MGAS9429_Spy1115.
PATRIC	19753282. VBIStrPyo37061_1131.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1020.
GeneTree	EBGT00050000027070.
HOGENOM	HBG320748.
OMA	QISHANL.
ProtClustDB	PRK04813.
Enzyme and pathway databases
BioCyc	SPYO370551:MGAS9429_SPY1115-MONOMER.
Family and domain databases
HAMAP	MF_00593. DltA. [Tree]
InterPro	IPR010071. AA_adenyl_domain. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR010072. D_ala_DACP_lig. [Graphical view]
KO	K03367.
PANTHER	PTHR24095:SF34. PTHR24095:SF34. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01733. AA-adenyl-dom. 1 hit. TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLTA_STRPC

Accession

Primary (citable) accession number: Q1JLB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program