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Q1JKL3

- PROB_STRPC

UniProt

Q1JKL3 - PROB_STRPC

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Protein
Glutamate 5-kinase
Gene
proB, MGAS9429_Spy1369
Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171ATP By similarity
Binding sitei57 – 571Substrate By similarity
Binding sitei144 – 1441Substrate By similarity
Binding sitei160 – 1601Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi180 – 1812ATP By similarity
Nucleotide bindingi222 – 2287ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO370551:GHLY-1440-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:MGAS9429_Spy1369
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS9429)
Taxonomic identifieri370551 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002433: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Glutamate 5-kinaseUniRule annotation
PRO_0000253005Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi370551.MGAS9429_Spy1369.

Structurei

3D structure databases

ProteinModelPortaliQ1JKL3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiADDFDSR.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JKL3-1 [UniParc]FASTAAdd to Basket

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MGMMKRQFED VTRIVIKIGT SSLVLPTGKI NLEKIDQLAF VISSLMNKGK    50
EVILVSSGAM GFGLDILKME KRPTNLAKQQ AVSSVGQVAM MSLYSQIFAH 100
YQTNVSQILL TRDVVVFPES LANVTNAFES LISLGIVPIV NENDAVSVDE 150
MDHATKFGDN DRLSAVVAGI TKADLLIMLS DIDGLFDKNP TIYEDAQLRS 200
HVAVITQEII ASAGGAGSKF GTGGMLSKIQ SAQMVFENKG QMVLMNGANP 250
RDILRVLEGQ PLGTWFKQIE EVTHD 275
Length:275
Mass (Da):29,863
Last modified:June 13, 2006 - v1
Checksum:iCDD34990A2C098F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000259 Genomic DNA. Translation: ABF32556.1.
RefSeqiYP_597100.1. NC_008021.1.

Genome annotation databases

EnsemblBacteriaiABF32556; ABF32556; MGAS9429_Spy1369.
GeneIDi4061815.
KEGGispk:MGAS9429_Spy1369.
PATRICi19753814. VBIStrPyo37061_1384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000259 Genomic DNA. Translation: ABF32556.1 .
RefSeqi YP_597100.1. NC_008021.1.

3D structure databases

ProteinModelPortali Q1JKL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370551.MGAS9429_Spy1369.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF32556 ; ABF32556 ; MGAS9429_Spy1369 .
GeneIDi 4061815.
KEGGi spk:MGAS9429_Spy1369.
PATRICi 19753814. VBIStrPyo37061_1384.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi ADDFDSR.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci SPYO370551:GHLY-1440-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS9429.

Entry informationi

Entry nameiPROB_STRPC
AccessioniPrimary (citable) accession number: Q1JKL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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