ID   LACB_STRPC              Reviewed;         171 AA.
AC   Q1JJZ6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit lacB;
DE            EC=5.3.1.26;
GN   Name=lacB; OrderedLocusNames=MGAS9429_Spy1640;
OS   Streptococcus pyogenes serotype M12 (strain MGAS9429).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370551;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F.,
RA   DeLeo F.R., Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in
RT   the human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- CATALYTIC ACTIVITY: D-galactose 6-phosphate = D-tagatose 6-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose degradation; D-
CC       tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of lacA and lacB (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the lacAB/rpiB family.
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DR   EMBL; CP000259; ABF32827.1; -; Genomic_DNA.
DR   RefSeq; YP_597371.1; -.
DR   GeneID; 4061439; -.
DR   GenomeReviews; CP000259_GR; MGAS9429_Spy1640.
DR   KEGG; spk:MGAS9429_Spy1640; -.
DR   HOGENOM; Q1JJZ6; -.
DR   OMA; Q1JJZ6; GHEIIDC.
DR   BioCyc; SPYO370551:MGAS9429_SPY1640-MON; -.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-ph...; IEA:HAMAP.
DR   HAMAP; MF_01556; -; 1.
DR   InterPro; IPR003500; Rib/Gal_isomrase.
DR   Gene3D; G3DSA:3.40.1400.10; Rib/Gal_isomrase; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Lactose metabolism.
FT   CHAIN         1    171       Galactose-6-phosphate isomerase subunit
FT                                lacB.
FT                                /FTId=PRO_1000068930.
SQ   SEQUENCE   171 AA;  18893 MW;  3253828AA1A30238 CRC64;
     MKIAVGCDHI VTYEKIAVVD YLKSQGHKVI DCGTYDNVRT HYPIFGKKVG EAVASGEAEL
     GVVICGTGVG ITNAVNKVPG IRSALVRDMT SAIYSKEELN ANVIGFGGKI IGGLLMNDII
     DAFLAAEYKP TEENKKWIEK MDSLQHASQD QNNPHFFDEF LEKWDRGEYH D
//