Q1JJZ6 (LACB_STRPC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-6-phosphate isomerase subunit lacB
EC=5.3.1.26

Gene names

Name:	lacB
Ordered Locus Names:	MGAS9429_Spy1640

Organism

Streptococcus pyogenes serotype M12 (strain MGAS9429) [Complete proteome] [HAMAP]

Taxonomic identifier

370551 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01556
Pathway	Carbohydrate metabolism; D-galactose 6-phosphate degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01556
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Galactose-6-phosphate isomerase subunit lacB HAMAP MF_01556		PRO_1000068930

Sequences

	Sequence		Length	Mass (Da)
	Q1JJZ6 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 3253828AA1A30238	FASTA	171	18,893
	10 20 30 40 50 60 MKIAVGCDHI VTYEKIAVVD YLKSQGHKVI DCGTYDNVRT HYPIFGKKVG EAVASGEAEL 70 80 90 100 110 120 GVVICGTGVG ITNAVNKVPG IRSALVRDMT SAIYSKEELN ANVIGFGGKI IGGLLMNDII 130 140 150 160 170 DAFLAAEYKP TEENKKWIEK MDSLQHASQD QNNPHFFDEF LEKWDRGEYH D

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS9429.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000259 Genomic DNA. Translation: ABF32827.1.
RefSeq	YP_597371.1. NC_008021.1.
3D structure databases
ProteinModelPortal	Q1JJZ6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JJZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000046850; EBSTRP00000045067; EBSTRG00000046842.
GeneID	4061439.
GenomeReviews	Gene locus MGAS9429_Spy1640 in contig CP000259_GR.
KEGG	spk:MGAS9429_Spy1640.
PATRIC	19754378. VBIStrPyo37061_1658.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0698.
GeneTree	EBGT00050000027286.
HOGENOM	HBG636953.
OMA	GHEIIDC.
ProtClustDB	PRK08622.
Enzyme and pathway databases
BioCyc	SPYO370551:MGAS9429_SPY1640-MONOMER.
Family and domain databases
HAMAP	MF_01556. LacB. [Tree]
InterPro	IPR004784. LacB. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
KO	K01819.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAM	SSF89623. Rib/Gal_isomrase. 1 hit.
TIGRFAMs	TIGR00689. RpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACB_STRPC

Accession

Primary (citable) accession number: Q1JJZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program