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Protein

Acetate kinase

Gene

ackA

Organism
Streptococcus pyogenes serotype M2 (strain MGAS10270)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi383MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi283 – 285ATPUniRule annotation3
Nucleotide bindingi331 – 335ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:MGAS10270_Spy0096
OrganismiStreptococcus pyogenes serotype M2 (strain MGAS10270)
Taxonomic identifieri370552 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002436 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022721 – 398Acetate kinaseAdd BLAST398

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JJ12.
SMRiQ1JJ12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JJ12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTIAINAG SSSLKWQLYQ MPEEAVLAQG IIERIGLKDS ISTVKYDGKK
60 70 80 90 100
EEQILDIHDH TEAVKILLND LIHFGIIAAY DEITGVGHRV VAGGELFKES
110 120 130 140 150
VVVNDKVLEH IEELSVLAPL HNPGAAAGIR AFRDILPDIT SVCVFDTSFH
160 170 180 190 200
TSMAKHTYLY PIPQKYYTDY KVRKYGAHGT SHKYVAQEAA KMLGRPLEEL
210 220 230 240 250
KLITAHIGNG VSITANYHGK SVDTSMGFTP LAGPMMGTRS GDIDPAIIPY
260 270 280 290 300
LIEQDPELKD AADVVNMLNK KSGLSGVSGI SSDMRDIEAG LQEDNPDAVL
310 320 330 340 350
AYNIFIDRIK KCIGQYFAVL NGADALVFTA GMGENAPLMR QDVIGGLTWF
360 370 380 390
GMDIDPEKNV FGYRGDISTP ESKVKVLVIS TDEELCIARD VERLKNTK
Length:398
Mass (Da):43,556
Last modified:June 13, 2006 - v1
Checksum:iE2C26750F1ECEE0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000260 Genomic DNA. Translation: ABF33161.1.
RefSeqiWP_020904834.1. NC_008022.1.

Genome annotation databases

EnsemblBacteriaiABF33161; ABF33161; MGAS10270_Spy0096.
KEGGisph:MGAS10270_Spy0096.

Similar proteinsi

Entry informationi

Entry nameiACKA_STRPD
AccessioniPrimary (citable) accession number: Q1JJ12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families