Q1JIP7 (NANE_STRPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosamine-6-phosphate 2-epimerase
EC=5.1.3.9

Alternative name(s):
ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	MGAS10270_Spy0211

Organism

Streptococcus pyogenes serotype M2 (strain MGAS10270) [Complete proteome] [HAMAP]

Taxonomic identifier

370552 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential. HAMAP MF_01235
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301492

Sequences

	Sequence		Length	Mass (Da)
	Q1JIP7 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 437D5F77DCB3046F	FASTA	234	25,136
	10 20 30 40 50 60 MPDKPTKEKL MEQLKGGIIV SCQALPGEPL YSETGGIMPL MAKAAQEAGA VGIRANSVRD 70 80 90 100 110 120 IKEIQAITDL PIIGIIKKDY PPQEPFITAT MIEVDQLAAL NIAVIAMDCT KRDRYDGLDI 130 140 150 160 170 180 ASFIRQVKEK YPNQLLMADI STFDEGLVAH QAGIDFVGTT LSGYTPYSRQ EAGPDMALIE 190 200 210 220 230 ALCKAGIAVI AEGKIHSPEE AKKINDLGVA GIVVGGAITR PKEIAERFIE ALKS

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS10270.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000260 Genomic DNA. Translation: ABF33276.1.
RefSeq	YP_597820.1. NC_008022.1.
3D structure databases
ProteinModelPortal	Q1JIP7.
SMR	Q1JIP7. Positions 4-233.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JIP7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000039857; EBSTRP00000038341; EBSTRG00000039855.
GeneID	4064285.
GenomeReviews	Gene locus nanE in contig CP000260_GR.
KEGG	sph:MGAS10270_Spy0211.
PATRIC	19718291. VBIStrPyo120482_0213.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3010.
GeneTree	EBGT00050000028071.
HOGENOM	HBG296941.
OMA	AITHPAT.
ProtClustDB	PRK01130.
Enzyme and pathway databases
BioCyc	SPYO370552:MGAS10270_SPY0211-MONOMER.
Family and domain databases
HAMAP	MF_01235. ManNAc6P_epimer. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR007260. NanE. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01788.
Pfam	PF04131. NanE. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NANE_STRPD

Accession

Primary (citable) accession number: Q1JIP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program