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Q1JFS6 (AROE_STRPD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:MGAS10270_Spy1418
OrganismStreptococcus pyogenes serotype M2 (strain MGAS10270) [Complete proteome] [HAMAP]
Taxonomic identifier370552 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Shikimate dehydrogenase HAMAP MF_00222
PRO_1000021348

Regions

Nucleotide binding135 – 1395NADP By similarity

Sites

Active site731Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
Q1JFS6 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: EE5E284D3E9610D7

FASTA29231,288
        10         20         30         40         50         60 
MSERLSGHTL LVSLLATPIR HSLSPKMHNE AYAKLGLDYA YLAFEVGTEQ LADAVQGIRA 

        70         80         90        100        110        120 
LGIRGSNVSM PNKEAILPLL DDLSPAAELV GAVNTVVNKD GKGHLVGHIT DGIGALRALA 

       130        140        150        160        170        180 
DEGVSVKNKI ITLAGVGGAG KAIAVQLAFD GAKEVRLFNR QATRLSSVQK LVTKLNQLTR 

       190        200        210        220        230        240 
TKVTLQDLED QTAFKEAIRE SHLFIDATSV GMKPLENLSL ITDPELIRPD LVVFDIVYSP 

       250        260        270        280        290 
AETKLLAFAR QHGAQKVING LGMVLYQGAE AFKLIIGQDM PVDAIKPLLG DE

« Hide

References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS10270.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000260 Genomic DNA. Translation: ABF34483.1.
RefSeqYP_599027.1. NC_008022.1.

3D structure databases

ProteinModelPortalQ1JFS6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1JFS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000041014; EBSTRP00000039498; EBSTRG00000041011.
GeneID4063235.
GenomeReviewsGene locus aroE in contig CP000260_GR.
KEGGsph:MGAS10270_Spy1418.
PATRIC19720776. VBIStrPyo120482_1444.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0169.
GeneTreeEBGT00050000027337.
HOGENOMHBG553408.
OMASIYIDAT.
ProtClustDBCLSK698780.

Enzyme and pathway databases

BioCycSPYO370552:MGAS10270_SPY1418-MONOMER.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_STRPD
AccessionPrimary (citable) accession number: Q1JFS6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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