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Q1JEK4

- FTHS2_STRPD

UniProt

Q1JEK4 - FTHS2_STRPD

Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Streptococcus pyogenes serotype M2 (strain MGAS10270)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO370552:GHYF-1917-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 2UniRule annotation
    Short name:
    FHS 2UniRule annotation
    Short name:
    FTHFS 2UniRule annotation
    Gene namesi
    Name:fhs2UniRule annotation
    Ordered Locus Names:MGAS10270_Spy1840
    OrganismiStreptococcus pyogenes serotype M2 (strain MGAS10270)
    Taxonomic identifieri370552 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002436: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligase 2PRO_0000293064Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370552.MGAS10270_Spy1840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JEK4.
    SMRiQ1JEK4. Positions 5-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1JEK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSDIEIAN SVSMEPISKV ADQLGIDKEA LCLYGKYKAK INARQLVALK    50
    DKPDGKLILV TTISPTPAGE GKTTTSVGLV DALSAIGKKA VIALREPSLG 100
    PVFGVKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH 150
    HGNSLGIDSR RITWKRVVDM NDRQLRHIVD GLQGKVNGVP REDGYDITVA 200
    SEIMAILCLS ENISDLKARL EKIIIGYNYQ GEPVTAKDLK AGGALAALLK 250
    DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYGDYAVTEA 300
    GFGADLGAEK FIDIKCRMSG LRPAAVVLVA TIRALKMHGG VPKADLATEN 350
    VQAVVDGLPN LDKHLANIQD VYGLPVVVAI NKFPLDTDAE LQAVYDACNK 400
    RGVDVVISDV WANGGAGGRE LAEKVVTLAE QDNQFRFVYE EDDSIETKLT 450
    KIVTKVYGGK GITLTPAAKR ELADLERLGF GNYPICMAKT QYSFSDDAKK 500
    LGAPTDFTVT ISNLKVSAGA GFIVALTGAI MTMPGLPKVP ASETIDIDEE 550
    GNITGLF 557
    Length:557
    Mass (Da):59,066
    Last modified:June 13, 2006 - v1
    Checksum:i4DFEB9DD8F5B11C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000260 Genomic DNA. Translation: ABF34905.1.
    RefSeqiYP_599449.1. NC_008022.1.

    Genome annotation databases

    EnsemblBacteriaiABF34905; ABF34905; MGAS10270_Spy1840.
    GeneIDi4063544.
    KEGGisph:MGAS10270_Spy1840.
    PATRICi19721678. VBIStrPyo120482_1873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000260 Genomic DNA. Translation: ABF34905.1 .
    RefSeqi YP_599449.1. NC_008022.1.

    3D structure databases

    ProteinModelPortali Q1JEK4.
    SMRi Q1JEK4. Positions 5-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370552.MGAS10270_Spy1840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF34905 ; ABF34905 ; MGAS10270_Spy1840 .
    GeneIDi 4063544.
    KEGGi sph:MGAS10270_Spy1840.
    PATRICi 19721678. VBIStrPyo120482_1873.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SPYO370552:GHYF-1917-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS10270.

    Entry informationi

    Entry nameiFTHS2_STRPD
    AccessioniPrimary (citable) accession number: Q1JEK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3