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Q1JEG8

- SYR_STRPD

UniProt

Q1JEG8 - SYR_STRPD

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Streptococcus pyogenes serotype M2 (strain MGAS10270)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO370552:GHYF-1977-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
    Alternative name(s):
    Arginyl-tRNA synthetaseUniRule annotation
    Short name:
    ArgRSUniRule annotation
    Gene namesi
    Name:argSUniRule annotation
    Ordered Locus Names:MGAS10270_Spy1900
    OrganismiStreptococcus pyogenes serotype M2 (strain MGAS10270)
    Taxonomic identifieri370552 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002436: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Arginine--tRNA ligasePRO_1000018130Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi370552.MGAS10270_Spy1900.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JEG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi121 – 13111"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247211.
    KOiK01887.
    OMAiYVKFHDE.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1JEG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTKTLIASE IAKVVPELEQ DAIFNLLETP KNSDMGDLAF PAFSLAKVLR    50
    KAPQMIASEL AEQIDESQFE KVVAVGPYIN FFLDKTKISS QVLEQVITAG 100
    SDYAQQDEGQ GRNVAIDMSS PNIAKPFSIG HLRSTVIGDS LAHIFAKMGY 150
    KPVKINHLGD WGKQFGMLIV AYKKWGDEAA VQAHPIDELL KLYVRINAEA 200
    ETDPTVDEEA REWFRKLEDG DKEATELWQW FRDESLLEFN RLYDQLHVTF 250
    DSYNGEAFYN DKMDEVLDLL EAKNLLVESK GAQVVNLEKY GIEHPALIKK 300
    SDGATLYITR DLAAALYRKR TYDFAKSVYV VGNEQAAHFK QLKAVLKEMG 350
    YDWSDDMTHV AFGLVTKGGA KLSTRKGNVI LLEPTVAEAI NRAASQIEAK 400
    NPNLADKEAV AHSVGVGAIK FYDLKTDRMN GYDFDLEAMV SFEGETGPYV 450
    QYAHARIQSI LRKADFTPSA TTTYSLADAE SWEIIKLIQD FPRIIKRTSD 500
    NFEPSIMAKF AINLAQSFNK YYAHTRILDD NSERDNRLAL CYATATVLKE 550
    ALRLLGVDAP NEM 563
    Length:563
    Mass (Da):63,167
    Last modified:June 13, 2006 - v1
    Checksum:iF21888DF3554D042
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000260 Genomic DNA. Translation: ABF34965.1.
    RefSeqiYP_599509.1. NC_008022.1.

    Genome annotation databases

    EnsemblBacteriaiABF34965; ABF34965; MGAS10270_Spy1900.
    GeneIDi4063931.
    KEGGisph:MGAS10270_Spy1900.
    PATRICi19721805. VBIStrPyo120482_1936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000260 Genomic DNA. Translation: ABF34965.1 .
    RefSeqi YP_599509.1. NC_008022.1.

    3D structure databases

    ProteinModelPortali Q1JEG8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370552.MGAS10270_Spy1900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF34965 ; ABF34965 ; MGAS10270_Spy1900 .
    GeneIDi 4063931.
    KEGGi sph:MGAS10270_Spy1900.
    PATRICi 19721805. VBIStrPyo120482_1936.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247211.
    KOi K01887.
    OMAi YVKFHDE.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci SPYO370552:GHYF-1977-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS10270.

    Entry informationi

    Entry nameiSYR_STRPD
    AccessioniPrimary (citable) accession number: Q1JEG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3