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Q1JCU0

- Q1JCU0_STRPB

UniProt

Q1JCU0 - Q1JCU0_STRPB

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei155 – 1551UniRule annotation
    Active sitei600 – 6001UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciSPYO370553:GH2N-568-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotationImported
    Ordered Locus Names:MGAS2096_Spy0516Imported
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)Imported
    Taxonomic identifieri370553 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002435: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi370553.MGAS2096_Spy0516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JCU0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2352.
    HOGENOMiHOG000238647.
    KOiK01595.
    OMAiELSTISC.
    OrthoDBiEOG6TJ7T8.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1JCU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKSGMIEET SKEGDGHLPL KKLESSNNQA IIAEEVALLK EMLENITRRM    50
    IGDDAFTVIE SIMVLSEKQD YIELEKVVAN ISNQEMEVIS RYFSILPLLI 100
    NISEDVDLAY EINYQNNTDT DYLGKLALTI KDLAGKDNGK DILEQVNVVP 150
    VLTAHPTQVQ RKTILELTTH IHKLLRKYRD AKAGVINLEK WRQELYRYIE 200
    MIMQTDIIRE KKLQVKNEIK NVMQYYDGSL IQAVTKLTTE YKNLAQKHGL 250
    ELDNPKPITM GMWIGGDRDG NPFVTAETLC LSATVQSEVI LNYYIDKLAA 300
    LYRTFSLSST LVQPNSEVER LASLSQDQSI YRGNEPYRRA FHYIQSRLKQ 350
    TQNQLTNQPA ARMSSSVGLN TSAWSSPASL ENPILAYDSP VDFKADLKAI 400
    EQSLLDNGNS ALIEGDLREV MQAVDIFGFF LASIDMRQDS SVQEACVAEL 450
    LKGANIVDDY SSLSETEKCD VLLQQLMEEP RTLSSAAVAK SDLLEKELAI 500
    YTTARELKDK LGEEVIKQHI ISHTESVSDM FELAIMLKEV GLVDQQRARV 550
    QIVPLFETIE DLDNARDIMA AYLSHDIVKS WIATNRNYQE IMLGYSDSNK 600
    DGGYLASGWT LYKAQNELTA IGEEHGVKIT FFHGRGGTVG RGGGPSYDAI 650
    TSQPFGSIKD RIRLTEQGEI IENKYGNKDV AYYHLEMLIS ASINRMVTQM 700
    ITDPNEIDSF REIMDSIVAD SNTIYRKLVF DNPHFYDYFF EASPIKEVSS 750
    LNIGSRPAAR KTITEITGLR AIPWVFSWSQ NRIMFPGWYG VGSAFKRYID 800
    RAQGNLERLQ HMYQTWPFFH SLLSNVDMVL SKSNMNIAFQ YAQLAESQDV 850
    RDVFYEILDE WQLTKNVILA IQDHDDLLED NPSLKHSLKS RLPYFNVLNY 900
    IQIELIKRWR NNQLDENDEK LIHTTINGIA TGLRNSG 937
    Length:937
    Mass (Da):106,495
    Last modified:June 13, 2006 - v1
    Checksum:i91E9B04033B33606
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF35568.1.
    RefSeqiYP_600112.1. NC_008023.1.

    Genome annotation databases

    EnsemblBacteriaiABF35568; ABF35568; MGAS2096_Spy0516.
    GeneIDi4065785.
    KEGGispj:MGAS2096_Spy0516.
    PATRICi19731501. VBIStrPyo133020_0534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF35568.1 .
    RefSeqi YP_600112.1. NC_008023.1.

    3D structure databases

    ProteinModelPortali Q1JCU0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370553.MGAS2096_Spy0516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF35568 ; ABF35568 ; MGAS2096_Spy0516 .
    GeneIDi 4065785.
    KEGGi spj:MGAS2096_Spy0516.
    PATRICi 19731501. VBIStrPyo133020_0534.

    Phylogenomic databases

    eggNOGi COG2352.
    HOGENOMi HOG000238647.
    KOi K01595.
    OMAi ELSTISC.
    OrthoDBi EOG6TJ7T8.

    Enzyme and pathway databases

    BioCyci SPYO370553:GH2N-568-MONOMER.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS2096Imported.

    Entry informationi

    Entry nameiQ1JCU0_STRPB
    AccessioniPrimary (citable) accession number: Q1JCU0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3