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Q1JCE8 (PYRB_STRPB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase

EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:MGAS2096_Spy0708
OrganismStreptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP]
Taxonomic identifier370553 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence caution

The sequence ABF35760.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Aspartate carbamoyltransferase HAMAP-Rule MF_00001
PRO_0000321163

Sequences

Sequence LengthMass (Da)Tools
Q1JCE8 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: D87E53C1864C7562

FASTA31134,596
        10         20         30         40         50         60 
MSVVNNRVAL TNLVSMEALT TEEVLGLINR GSEYKAGKVV ISDHQKDLVA NLFFENSTRT 

        70         80         90        100        110        120 
HKSFEVAEKK LGLTVLDFNA DASAVNKGES LYDTVLTMSA LGTDICVIRH PEDDYYKELV 

       130        140        150        160        170        180 
ESPTITASIV NGGDGSGQHP SQCLLDLLTI YEEFGHFEGL KIAIAGDLTH SRVAKSNMQI 

       190        200        210        220        230        240 
LKRLGAELYF YGPEEWYSEA FNAYGTYIAI DQIIKELDVL MLLRVQHERH DGHQSFSKEG 

       250        260        270        280        290        300 
YHQAFGLTQE RYQQLKDSAI IMHPAPVNRD VEIADSLVEA PKARIVSQMA NGVFVRMAII 

       310 
EAILNGRNKN S 

« Hide

References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS2096.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000261 Genomic DNA. Translation: ABF35760.1. Different initiation.
RefSeqYP_600304.1. NC_008023.1.

3D structure databases

ProteinModelPortalQ1JCE8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370553.MGAS2096_Spy0708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF35760; ABF35760; MGAS2096_Spy0708.
GeneID4065316.
KEGGspj:MGAS2096_Spy0708.
PATRIC19731887. VBIStrPyo133020_0726.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0540.
HOGENOMHOG000022685.
KOK00609.
OrthoDBEOG61KBJZ.
ProtClustDBPRK00856.

Enzyme and pathway databases

BioCycSPYO370553:GH2N-761-MONOMER.
UniPathwayUPA00070; UER00116.

Family and domain databases

Gene3D3.40.50.1370. 2 hits.
HAMAPMF_00001. Asp_carb_tr.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. SSF53671. 1 hit.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_STRPB
AccessionPrimary (citable) accession number: Q1JCE8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways