Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1JCE8

- PYRB_STRPB

UniProt

Q1JCE8 - PYRB_STRPB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. aspartate carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-761-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:MGAS2096_Spy0708
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002435: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Aspartate carbamoyltransferasePRO_0000321163Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi370553.MGAS2096_Spy0708.

Structurei

3D structure databases

ProteinModelPortaliQ1JCE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0540.
HOGENOMiHOG000022685.
KOiK00609.
OrthoDBiEOG61KBJZ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JCE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVVNNRVAL TNLVSMEALT TEEVLGLINR GSEYKAGKVV ISDHQKDLVA
60 70 80 90 100
NLFFENSTRT HKSFEVAEKK LGLTVLDFNA DASAVNKGES LYDTVLTMSA
110 120 130 140 150
LGTDICVIRH PEDDYYKELV ESPTITASIV NGGDGSGQHP SQCLLDLLTI
160 170 180 190 200
YEEFGHFEGL KIAIAGDLTH SRVAKSNMQI LKRLGAELYF YGPEEWYSEA
210 220 230 240 250
FNAYGTYIAI DQIIKELDVL MLLRVQHERH DGHQSFSKEG YHQAFGLTQE
260 270 280 290 300
RYQQLKDSAI IMHPAPVNRD VEIADSLVEA PKARIVSQMA NGVFVRMAII
310
EAILNGRNKN S
Length:311
Mass (Da):34,596
Last modified:February 26, 2008 - v2
Checksum:iD87E53C1864C7562
GO

Sequence cautioni

The sequence ABF35760.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000261 Genomic DNA. Translation: ABF35760.1. Different initiation.
RefSeqiYP_600304.1. NC_008023.1.

Genome annotation databases

EnsemblBacteriaiABF35760; ABF35760; MGAS2096_Spy0708.
GeneIDi4065316.
KEGGispj:MGAS2096_Spy0708.
PATRICi19731887. VBIStrPyo133020_0726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000261 Genomic DNA. Translation: ABF35760.1 . Different initiation.
RefSeqi YP_600304.1. NC_008023.1.

3D structure databases

ProteinModelPortali Q1JCE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370553.MGAS2096_Spy0708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF35760 ; ABF35760 ; MGAS2096_Spy0708 .
GeneIDi 4065316.
KEGGi spj:MGAS2096_Spy0708.
PATRICi 19731887. VBIStrPyo133020_0726.

Phylogenomic databases

eggNOGi COG0540.
HOGENOMi HOG000022685.
KOi K00609.
OrthoDBi EOG61KBJZ.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00116 .
BioCyci SPYO370553:GH2N-761-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_00001. Asp_carb_tr.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00670. asp_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS2096.

Entry informationi

Entry nameiPYRB_STRPB
AccessioniPrimary (citable) accession number: Q1JCE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 1, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3