Q1JCE8 (PYRB_STRPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	MGAS2096_Spy0708

Organism

Streptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP]

Taxonomic identifier

370553 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M12

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.
Sequence caution	The sequence ABF35760.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_0000321163

Sequences

	Sequence		Length	Mass (Da)
	Q1JCE8 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: D87E53C1864C7562	FASTA	311	34,596
	10 20 30 40 50 60 MSVVNNRVAL TNLVSMEALT TEEVLGLINR GSEYKAGKVV ISDHQKDLVA NLFFENSTRT 70 80 90 100 110 120 HKSFEVAEKK LGLTVLDFNA DASAVNKGES LYDTVLTMSA LGTDICVIRH PEDDYYKELV 130 140 150 160 170 180 ESPTITASIV NGGDGSGQHP SQCLLDLLTI YEEFGHFEGL KIAIAGDLTH SRVAKSNMQI 190 200 210 220 230 240 LKRLGAELYF YGPEEWYSEA FNAYGTYIAI DQIIKELDVL MLLRVQHERH DGHQSFSKEG 250 260 270 280 290 300 YHQAFGLTQE RYQQLKDSAI IMHPAPVNRD VEIADSLVEA PKARIVSQMA NGVFVRMAII 310 EAILNGRNKN S

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS2096.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000261 Genomic DNA. Translation: ABF35760.1. Different initiation.
RefSeq	YP_600304.1. NC_008023.1.
3D structure databases
ProteinModelPortal	Q1JCE8.
ModBase	Search...
Protein-protein interaction databases
STRING	370553.MGAS2096_Spy0708.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF35760; ABF35760; MGAS2096_Spy0708.
GeneID	4065316.
KEGG	spj:MGAS2096_Spy0708.
PATRIC	19731887. VBIStrPyo133020_0726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
ProtClustDB	PRK00856.
Enzyme and pathway databases
UniPathway	UPA00070; UER00116.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STRPB

Accession

Primary (citable) accession number: Q1JCE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program