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Q1JCE8

- PYRB_STRPB

UniProt

Q1JCE8 - PYRB_STRPB

Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. aspartate carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    3. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciSPYO370553:GH2N-761-MONOMER.
    UniPathwayiUPA00070; UER00116.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
    Alternative name(s):
    Aspartate transcarbamylaseUniRule annotation
    Short name:
    ATCaseUniRule annotation
    Gene namesi
    Name:pyrBUniRule annotation
    Ordered Locus Names:MGAS2096_Spy0708
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
    Taxonomic identifieri370553 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002435: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Aspartate carbamoyltransferasePRO_0000321163Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370553.MGAS2096_Spy0708.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JCE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0540.
    HOGENOMiHOG000022685.
    KOiK00609.
    OrthoDBiEOG61KBJZ.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_00001. Asp_carb_tr.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR002082. Asp_carbamoyltransf.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00101. ATCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1JCE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVVNNRVAL TNLVSMEALT TEEVLGLINR GSEYKAGKVV ISDHQKDLVA    50
    NLFFENSTRT HKSFEVAEKK LGLTVLDFNA DASAVNKGES LYDTVLTMSA 100
    LGTDICVIRH PEDDYYKELV ESPTITASIV NGGDGSGQHP SQCLLDLLTI 150
    YEEFGHFEGL KIAIAGDLTH SRVAKSNMQI LKRLGAELYF YGPEEWYSEA 200
    FNAYGTYIAI DQIIKELDVL MLLRVQHERH DGHQSFSKEG YHQAFGLTQE 250
    RYQQLKDSAI IMHPAPVNRD VEIADSLVEA PKARIVSQMA NGVFVRMAII 300
    EAILNGRNKN S 311
    Length:311
    Mass (Da):34,596
    Last modified:February 26, 2008 - v2
    Checksum:iD87E53C1864C7562
    GO

    Sequence cautioni

    The sequence ABF35760.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF35760.1. Different initiation.
    RefSeqiYP_600304.1. NC_008023.1.

    Genome annotation databases

    EnsemblBacteriaiABF35760; ABF35760; MGAS2096_Spy0708.
    GeneIDi4065316.
    KEGGispj:MGAS2096_Spy0708.
    PATRICi19731887. VBIStrPyo133020_0726.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF35760.1 . Different initiation.
    RefSeqi YP_600304.1. NC_008023.1.

    3D structure databases

    ProteinModelPortali Q1JCE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370553.MGAS2096_Spy0708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF35760 ; ABF35760 ; MGAS2096_Spy0708 .
    GeneIDi 4065316.
    KEGGi spj:MGAS2096_Spy0708.
    PATRICi 19731887. VBIStrPyo133020_0726.

    Phylogenomic databases

    eggNOGi COG0540.
    HOGENOMi HOG000022685.
    KOi K00609.
    OrthoDBi EOG61KBJZ.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00116 .
    BioCyci SPYO370553:GH2N-761-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_00001. Asp_carb_tr.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR002082. Asp_carbamoyltransf.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00101. ATCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00670. asp_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS2096.

    Entry informationi

    Entry nameiPYRB_STRPB
    AccessioniPrimary (citable) accession number: Q1JCE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3