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Q1JCC9

- FENR_STRPB

UniProt

Q1JCC9 - FENR_STRPB

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Protein

Ferredoxin--NADP reductase

Gene

MGAS2096_Spy0727

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351FADUniRule annotation
Binding sitei43 – 431FADUniRule annotation
Binding sitei48 – 481FADUniRule annotation
Binding sitei90 – 901FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei123 – 1231FAD; via amide nitrogenUniRule annotation
Binding sitei285 – 2851FADUniRule annotation
Binding sitei326 – 3261FADUniRule annotation

GO - Molecular functioni

  1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. NADP binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
Short name:
FNRUniRule annotation
Short name:
Fd-NADP(+) reductaseUniRule annotation
Gene namesi
Ordered Locus Names:MGAS2096_Spy0727
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002435: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Ferredoxin--NADP reductasePRO_0000364963Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi370553.MGAS2096_Spy0727.

Structurei

3D structure databases

ProteinModelPortaliQ1JCC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072909.
KOiK00384.
OMAiVIVNFGF.
OrthoDBiEOG661H9M.

Family and domain databases

HAMAPiMF_01685. FENR2.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.

Sequencei

Sequence statusi: Complete.

Q1JCC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDKAYDITI IGGGPIGLFA AFYAGLRGVT VKIIESLSEL GGQPAILYPE
60 70 80 90 100
KMIYDIPAYP SLTGVELTEN LIKQLSRFED RTTICLKEEV LTFDKVKGGF
110 120 130 140 150
SIRTNKAEHF SKAIIIACGN GAFAPRTLGL ESEENFADHN LFYNVHQLDQ
160 170 180 190 200
FAGQKVVICG GGDSAVDWAL ALEDIAESVT VVHRRDAFRA HEHSVELLKT
210 220 230 240 250
STVNLLTPYV PKALKGIGNL AEKLVIQKVK EDEVLELELD SLIVSFGFST
260 270 280 290 300
SNKNLKNWNL DYKRSSITVS PLFQTSQEGI FAIGDAAAYN GKVDLIATGF
310 320 330
GEAPTAVNQA INYIYPDRDN RVVHSTSLID
Length:330
Mass (Da):36,148
Last modified:June 13, 2006 - v1
Checksum:iEECC6544A10319DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF35779.1.
RefSeqiYP_600323.1. NC_008023.1.

Genome annotation databases

EnsemblBacteriaiABF35779; ABF35779; MGAS2096_Spy0727.
GeneIDi4066150.
KEGGispj:MGAS2096_Spy0727.
PATRICi19731925. VBIStrPyo133020_0745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF35779.1 .
RefSeqi YP_600323.1. NC_008023.1.

3D structure databases

ProteinModelPortali Q1JCC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370553.MGAS2096_Spy0727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF35779 ; ABF35779 ; MGAS2096_Spy0727 .
GeneIDi 4066150.
KEGGi spj:MGAS2096_Spy0727.
PATRICi 19731925. VBIStrPyo133020_0745.

Phylogenomic databases

eggNOGi COG0492.
HOGENOMi HOG000072909.
KOi K00384.
OMAi VIVNFGF.
OrthoDBi EOG661H9M.

Enzyme and pathway databases

BioCyci SPYO370553:GH2N-780-MONOMER.

Family and domain databases

HAMAPi MF_01685. FENR2.
InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS2096.

Entry informationi

Entry nameiFENR_STRPB
AccessioniPrimary (citable) accession number: Q1JCC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 13, 2006
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3