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Q1JCC9 (FENR_STRPB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferredoxin--NADP reductase

Short name=FNR
Short name=Fd-NADP(+) reductase
EC=1.18.1.2
Gene names
Ordered Locus Names:MGAS2096_Spy0727
OrganismStreptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP]
Taxonomic identifier370553 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP-Rule MF_01685

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP-Rule MF_01685

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01685

Sequence similarities

Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ferredoxin-NADP+ reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Ferredoxin--NADP reductase HAMAP-Rule MF_01685
PRO_0000364963

Sites

Binding site351FAD By similarity
Binding site431FAD By similarity
Binding site481FAD By similarity
Binding site901FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site1231FAD; via amide nitrogen By similarity
Binding site2851FAD By similarity
Binding site3261FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1JCC9 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: EECC6544A10319DC

FASTA33036,148
        10         20         30         40         50         60 
MKDKAYDITI IGGGPIGLFA AFYAGLRGVT VKIIESLSEL GGQPAILYPE KMIYDIPAYP 

        70         80         90        100        110        120 
SLTGVELTEN LIKQLSRFED RTTICLKEEV LTFDKVKGGF SIRTNKAEHF SKAIIIACGN 

       130        140        150        160        170        180 
GAFAPRTLGL ESEENFADHN LFYNVHQLDQ FAGQKVVICG GGDSAVDWAL ALEDIAESVT 

       190        200        210        220        230        240 
VVHRRDAFRA HEHSVELLKT STVNLLTPYV PKALKGIGNL AEKLVIQKVK EDEVLELELD 

       250        260        270        280        290        300 
SLIVSFGFST SNKNLKNWNL DYKRSSITVS PLFQTSQEGI FAIGDAAAYN GKVDLIATGF 

       310        320        330 
GEAPTAVNQA INYIYPDRDN RVVHSTSLID 

« Hide

References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS2096.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000261 Genomic DNA. Translation: ABF35779.1.
RefSeqYP_600323.1. NC_008023.1.

3D structure databases

ProteinModelPortalQ1JCC9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370553.MGAS2096_Spy0727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF35779; ABF35779; MGAS2096_Spy0727.
GeneID4066150.
KEGGspj:MGAS2096_Spy0727.
PATRIC19731925. VBIStrPyo133020_0745.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0492.
HOGENOMHOG000072909.
KOK00384.
OMAESMPQLG.
OrthoDBEOG661H9M.
ProtClustDBCLSK698502.

Enzyme and pathway databases

BioCycSPYO370553:GH2N-780-MONOMER.

Family and domain databases

HAMAPMF_01685. FENR2.
InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNetSearch...

Entry information

Entry nameFENR_STRPB
AccessionPrimary (citable) accession number: Q1JCC9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 13, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families