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Q1JCC9

- FENR_STRPB

UniProt

Q1JCC9 - FENR_STRPB

Protein

Ferredoxin--NADP reductase

Gene

MGAS2096_Spy0727

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

    Cofactori

    Binds 1 FAD per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351FADUniRule annotation
    Binding sitei43 – 431FADUniRule annotation
    Binding sitei48 – 481FADUniRule annotation
    Binding sitei90 – 901FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei123 – 1231FAD; via amide nitrogenUniRule annotation
    Binding sitei285 – 2851FADUniRule annotation
    Binding sitei326 – 3261FADUniRule annotation

    GO - Molecular functioni

    1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciSPYO370553:GH2N-780-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
    Short name:
    FNRUniRule annotation
    Short name:
    Fd-NADP(+) reductaseUniRule annotation
    Gene namesi
    Ordered Locus Names:MGAS2096_Spy0727
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
    Taxonomic identifieri370553 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002435: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Ferredoxin--NADP reductasePRO_0000364963Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi370553.MGAS2096_Spy0727.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JCC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0492.
    HOGENOMiHOG000072909.
    KOiK00384.
    OMAiVIVNFGF.
    OrthoDBiEOG661H9M.

    Family and domain databases

    HAMAPiMF_01685. FENR2.
    InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR022890. Fd--NADP_Rdtase_type_2.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    PR00469. PNDRDTASEII.

    Sequencei

    Sequence statusi: Complete.

    Q1JCC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDKAYDITI IGGGPIGLFA AFYAGLRGVT VKIIESLSEL GGQPAILYPE    50
    KMIYDIPAYP SLTGVELTEN LIKQLSRFED RTTICLKEEV LTFDKVKGGF 100
    SIRTNKAEHF SKAIIIACGN GAFAPRTLGL ESEENFADHN LFYNVHQLDQ 150
    FAGQKVVICG GGDSAVDWAL ALEDIAESVT VVHRRDAFRA HEHSVELLKT 200
    STVNLLTPYV PKALKGIGNL AEKLVIQKVK EDEVLELELD SLIVSFGFST 250
    SNKNLKNWNL DYKRSSITVS PLFQTSQEGI FAIGDAAAYN GKVDLIATGF 300
    GEAPTAVNQA INYIYPDRDN RVVHSTSLID 330
    Length:330
    Mass (Da):36,148
    Last modified:June 13, 2006 - v1
    Checksum:iEECC6544A10319DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF35779.1.
    RefSeqiYP_600323.1. NC_008023.1.

    Genome annotation databases

    EnsemblBacteriaiABF35779; ABF35779; MGAS2096_Spy0727.
    GeneIDi4066150.
    KEGGispj:MGAS2096_Spy0727.
    PATRICi19731925. VBIStrPyo133020_0745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF35779.1 .
    RefSeqi YP_600323.1. NC_008023.1.

    3D structure databases

    ProteinModelPortali Q1JCC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370553.MGAS2096_Spy0727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF35779 ; ABF35779 ; MGAS2096_Spy0727 .
    GeneIDi 4066150.
    KEGGi spj:MGAS2096_Spy0727.
    PATRICi 19731925. VBIStrPyo133020_0745.

    Phylogenomic databases

    eggNOGi COG0492.
    HOGENOMi HOG000072909.
    KOi K00384.
    OMAi VIVNFGF.
    OrthoDBi EOG661H9M.

    Enzyme and pathway databases

    BioCyci SPYO370553:GH2N-780-MONOMER.

    Family and domain databases

    HAMAPi MF_01685. FENR2.
    InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR022890. Fd--NADP_Rdtase_type_2.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    PR00469. PNDRDTASEII.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS2096.

    Entry informationi

    Entry nameiFENR_STRPB
    AccessioniPrimary (citable) accession number: Q1JCC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3