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Protein

Ferredoxin--NADP reductase

Gene

MGAS2096_Spy0727

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35FADUniRule annotation1
Binding sitei43FADUniRule annotation1
Binding sitei48FADUniRule annotation1
Binding sitei90FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei123FAD; via amide nitrogenUniRule annotation1
Binding sitei285FADUniRule annotation1
Binding sitei326FADUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-779-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
Short name:
FNRUniRule annotation
Short name:
Fd-NADP(+) reductaseUniRule annotation
Gene namesi
Ordered Locus Names:MGAS2096_Spy0727
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003649631 – 330Ferredoxin--NADP reductaseAdd BLAST330

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JCC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000072909.
KOiK00384.
OMAiLDYQTNI.
OrthoDBiPOG091H07EY.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_01685. FENR2. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JCC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDKAYDITI IGGGPIGLFA AFYAGLRGVT VKIIESLSEL GGQPAILYPE
60 70 80 90 100
KMIYDIPAYP SLTGVELTEN LIKQLSRFED RTTICLKEEV LTFDKVKGGF
110 120 130 140 150
SIRTNKAEHF SKAIIIACGN GAFAPRTLGL ESEENFADHN LFYNVHQLDQ
160 170 180 190 200
FAGQKVVICG GGDSAVDWAL ALEDIAESVT VVHRRDAFRA HEHSVELLKT
210 220 230 240 250
STVNLLTPYV PKALKGIGNL AEKLVIQKVK EDEVLELELD SLIVSFGFST
260 270 280 290 300
SNKNLKNWNL DYKRSSITVS PLFQTSQEGI FAIGDAAAYN GKVDLIATGF
310 320 330
GEAPTAVNQA INYIYPDRDN RVVHSTSLID
Length:330
Mass (Da):36,148
Last modified:June 13, 2006 - v1
Checksum:iEECC6544A10319DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF35779.1.
RefSeqiWP_002990220.1. NC_008023.1.

Genome annotation databases

EnsemblBacteriaiABF35779; ABF35779; MGAS2096_Spy0727.
KEGGispj:MGAS2096_Spy0727.
PATRICi19731925. VBIStrPyo133020_0745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF35779.1.
RefSeqiWP_002990220.1. NC_008023.1.

3D structure databases

ProteinModelPortaliQ1JCC9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF35779; ABF35779; MGAS2096_Spy0727.
KEGGispj:MGAS2096_Spy0727.
PATRICi19731925. VBIStrPyo133020_0745.

Phylogenomic databases

HOGENOMiHOG000072909.
KOiK00384.
OMAiLDYQTNI.
OrthoDBiPOG091H07EY.

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-779-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_01685. FENR2. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFENR_STRPB
AccessioniPrimary (citable) accession number: Q1JCC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.