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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4Purine nucleoside; shared with dimeric partnerBy similarity1
Binding sitei20Phosphate; via amide nitrogenBy similarity1
Binding sitei24PhosphateBy similarity1
Binding sitei43Phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:MGAS2096_Spy0771
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001862281 – 237Purine nucleoside phosphorylase DeoD-typeAdd BLAST237

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JC85
SMRiQ1JC85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 90Phosphate bindingBy similarity4
Regioni179 – 181Purine nucleoside bindingBy similarity3
Regioni203 – 204Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000274896
KOiK03784
OMAiPQCLLCG
OrthoDBiPOG091H02M1

Family and domain databases

HAMAPiMF_01627 Pur_nucleosid_phosp, 1 hit
InterProiView protein in InterPro
IPR004402 DeoD-type
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR43691:SF2 PTHR43691:SF2, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR00107 deoD, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q1JC85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHISAKKG DIADKILLPG DPLRAKFIAE NFLEDAVCFN EVRNMFGYTG
60 70 80 90 100
TYKGHRVSVM GTGMGMPSIS IYARELIVDY GVKTLIRVGT AGAIDPEVHV
110 120 130 140 150
RELVLAQAAA TNSNIIRNDF PEFDFPQIAD FGLLDKAYHI AREMGVTTHV
160 170 180 190 200
GNVLSSDVFY TNMPERNMAL GKLGVKAIEM EAAALYYLAA QHHVKALGIM
210 220 230
TISDNLNDPT EDTTAEERQT TFTDMMKVGL ETLIAND
Length:237
Mass (Da):26,020
Last modified:June 13, 2006 - v1
Checksum:i097EDDF0A34732E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA Translation: ABF35823.1

Genome annotation databases

EnsemblBacteriaiABF35823; ABF35823; MGAS2096_Spy0771
KEGGispj:MGAS2096_Spy0771

Similar proteinsi

Entry informationi

Entry nameiDEOD_STRPB
AccessioniPrimary (citable) accession number: Q1JC85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 13, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health