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Q1JBM0

- FTHS1_STRPB

UniProt

Q1JBM0 - FTHS1_STRPB

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Protein
Formate--tetrahydrofolate ligase 1
Gene
fhs1, MGAS2096_Spy0986
Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-1042-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name:
FHS 1
Short name:
FTHFS 1
Gene namesi
Name:fhs1
Ordered Locus Names:MGAS2096_Spy0986
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002435: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligase 1UniRule annotation
PRO_0000293059Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi370553.MGAS2096_Spy0986.

Structurei

3D structure databases

ProteinModelPortaliQ1JBM0.
SMRiQ1JBM0. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1JBM0-1 [UniParc]FASTAAdd to Basket

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MKSDIEIAQS VALQPITDIV KKVGIDGDDI ELYGKYKAKL SFEKMKAVEA    50
NEPGKLILVT AINPTPAGEG KSTMSIGLAD ALNQMGKKTM LALREPSLGP 100
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLQQ 150
GNDLGIDPRR IIWKRVLDLN DRALRQVIVG LGSPVNGVPR EDGFDITVAS 200
EIMAILCLAT DLKDLKKRLA DIVVAYTYDR KPVYVRDLKV EGALTLILKD 250
AIKPNLVQTI YGTPALIHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 300
FGADLGAEKF LNIKVPNLPK APDAIVIVAT LRALKMHGGV AKSDLAAENC 350
EAVRLGFANL KRHVENMRQF KVPVVVAINE FVADTEAEIA TLKALCEEIK 400
VPVELASVWA NGAEGGLALA KTVVRVIDQE AADYKRLYSD EDTLEEKVIN 450
IVTQIYGGKA VQFGPKAKTQ LKQFAEFGWD KLPVCMAKTQ YSFSDNPSLL 500
GAPTDFDITI REFVPKTGAG FIVGLTGDVM TMPGLPKVPA AMAMDVAENG 550
TALGLF 556
Length:556
Mass (Da):59,531
Last modified:June 13, 2006 - v1
Checksum:i90C6D132DF20EE3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000261 Genomic DNA. Translation: ABF36038.1.
RefSeqiYP_600582.1. NC_008023.1.

Genome annotation databases

EnsemblBacteriaiABF36038; ABF36038; MGAS2096_Spy0986.
GeneIDi4065814.
KEGGispj:MGAS2096_Spy0986.
PATRICi19732463. VBIStrPyo133020_1011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000261 Genomic DNA. Translation: ABF36038.1 .
RefSeqi YP_600582.1. NC_008023.1.

3D structure databases

ProteinModelPortali Q1JBM0.
SMRi Q1JBM0. Positions 4-554.
ModBasei Search...

Protein-protein interaction databases

STRINGi 370553.MGAS2096_Spy0986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF36038 ; ABF36038 ; MGAS2096_Spy0986 .
GeneIDi 4065814.
KEGGi spj:MGAS2096_Spy0986.
PATRICi 19732463. VBIStrPyo133020_1011.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPYO370553:GH2N-1042-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS2096.

Entry informationi

Entry nameiFTHS1_STRPB
AccessioniPrimary (citable) accession number: Q1JBM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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