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Q1JAJ7 (FMT_STRPB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase

EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:MGAS2096_Spy1359
OrganismStreptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP]
Taxonomic identifier370553 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_1000020177

Regions

Region110 – 1134Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1JAJ7 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 9B074058EBDEDCA7

FASTA31133,675
        10         20         30         40         50         60 
MIKLLFMGTP QFSATVLKGL LDNPAYEILG VVTQPDRAVG RKKDIKVTPV KQLALEHGIS 

        70         80         90        100        110        120 
IYQPEKLSGS QELIEIMGLG ADGIITAAFG QFLPTLLLDS VSFAINVHAS LLPKYRGGAP 

       130        140        150        160        170        180 
IHYAIMNGDK EAGVTIMEMI KEMDAGDMVA KASTPILETD NVGTLFEKLA IIGRDLLLDS 

       190        200        210        220        230        240 
LPAYLSGELK PIPQDHSQAT FSPNISPEQE KLDWTMSNQE VFNHIRGMNP WPVAHTFLEG 

       250        260        270        280        290        300 
QRLKIYEAQL AEGEGLPGQV IVKTKKSLVI ATGQGALSLI VVQPAGKPKM SIIDFLNGIG 

       310 
RKLEVGDIIG R 

« Hide

References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS2096.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000261 Genomic DNA. Translation: ABF36411.1.
RefSeqYP_600955.1. NC_008023.1.

3D structure databases

ProteinModelPortalQ1JAJ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370553.MGAS2096_Spy1359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF36411; ABF36411; MGAS2096_Spy1359.
GeneID4064725.
KEGGspj:MGAS2096_Spy1359.
PATRIC19733245. VBIStrPyo133020_1390.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0223.
HOGENOMHOG000261177.
KOK00604.
OMAKAQAQNE.
OrthoDBEOG6B09WV.

Enzyme and pathway databases

BioCycSPYO370553:GH2N-1427-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
PROSITEPS00373. GART. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFMT_STRPB
AccessionPrimary (citable) accession number: Q1JAJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families