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Q1JAJ7

- FMT_STRPB

UniProt

Q1JAJ7 - FMT_STRPB

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
    2. methyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciSPYO370553:GH2N-1427-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
    Gene namesi
    Name:fmtUniRule annotation
    Ordered Locus Names:MGAS2096_Spy1359
    OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
    Taxonomic identifieri370553 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002435: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Methionyl-tRNA formyltransferasePRO_1000020177Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370553.MGAS2096_Spy1359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1JAJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 1134Tetrahydrofolate (THF) bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Fmt family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0223.
    HOGENOMiHOG000261177.
    KOiK00604.
    OMAiKAQAQNE.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.
    PROSITEiPS00373. GART. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1JAJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKLLFMGTP QFSATVLKGL LDNPAYEILG VVTQPDRAVG RKKDIKVTPV    50
    KQLALEHGIS IYQPEKLSGS QELIEIMGLG ADGIITAAFG QFLPTLLLDS 100
    VSFAINVHAS LLPKYRGGAP IHYAIMNGDK EAGVTIMEMI KEMDAGDMVA 150
    KASTPILETD NVGTLFEKLA IIGRDLLLDS LPAYLSGELK PIPQDHSQAT 200
    FSPNISPEQE KLDWTMSNQE VFNHIRGMNP WPVAHTFLEG QRLKIYEAQL 250
    AEGEGLPGQV IVKTKKSLVI ATGQGALSLI VVQPAGKPKM SIIDFLNGIG 300
    RKLEVGDIIG R 311
    Length:311
    Mass (Da):33,675
    Last modified:June 13, 2006 - v1
    Checksum:i9B074058EBDEDCA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF36411.1.
    RefSeqiYP_600955.1. NC_008023.1.

    Genome annotation databases

    EnsemblBacteriaiABF36411; ABF36411; MGAS2096_Spy1359.
    GeneIDi4064725.
    KEGGispj:MGAS2096_Spy1359.
    PATRICi19733245. VBIStrPyo133020_1390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000261 Genomic DNA. Translation: ABF36411.1 .
    RefSeqi YP_600955.1. NC_008023.1.

    3D structure databases

    ProteinModelPortali Q1JAJ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370553.MGAS2096_Spy1359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF36411 ; ABF36411 ; MGAS2096_Spy1359 .
    GeneIDi 4064725.
    KEGGi spj:MGAS2096_Spy1359.
    PATRICi 19733245. VBIStrPyo133020_1390.

    Phylogenomic databases

    eggNOGi COG0223.
    HOGENOMi HOG000261177.
    KOi K00604.
    OMAi KAQAQNE.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci SPYO370553:GH2N-1427-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    PROSITEi PS00373. GART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS2096.

    Entry informationi

    Entry nameiFMT_STRPB
    AccessioniPrimary (citable) accession number: Q1JAJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3