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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:MGAS2096_Spy1359
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201771 – 311Methionyl-tRNA formyltransferaseAdd BLAST311

Structurei

3D structure databases

ProteinModelPortaliQ1JAJ7
SMRiQ1JAJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q1JAJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLLFMGTP QFSATVLKGL LDNPAYEILG VVTQPDRAVG RKKDIKVTPV
60 70 80 90 100
KQLALEHGIS IYQPEKLSGS QELIEIMGLG ADGIITAAFG QFLPTLLLDS
110 120 130 140 150
VSFAINVHAS LLPKYRGGAP IHYAIMNGDK EAGVTIMEMI KEMDAGDMVA
160 170 180 190 200
KASTPILETD NVGTLFEKLA IIGRDLLLDS LPAYLSGELK PIPQDHSQAT
210 220 230 240 250
FSPNISPEQE KLDWTMSNQE VFNHIRGMNP WPVAHTFLEG QRLKIYEAQL
260 270 280 290 300
AEGEGLPGQV IVKTKKSLVI ATGQGALSLI VVQPAGKPKM SIIDFLNGIG
310
RKLEVGDIIG R
Length:311
Mass (Da):33,675
Last modified:June 13, 2006 - v1
Checksum:i9B074058EBDEDCA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA Translation: ABF36411.1

Genome annotation databases

EnsemblBacteriaiABF36411; ABF36411; MGAS2096_Spy1359
KEGGispj:MGAS2096_Spy1359

Similar proteinsi

Entry informationi

Entry nameiFMT_STRPB
AccessioniPrimary (citable) accession number: Q1JAJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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