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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57IronUniRule annotation1
Metal bindingi61IronUniRule annotation1
Metal bindingi127IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:MGAS2096_Spy1371
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002980421 – 160S-ribosylhomocysteine lyaseAdd BLAST160

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1JAI5
SMRiQ1JAI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040372
KOiK07173
OrthoDBiPOG091H0623

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit

Sequencei

Sequence statusi: Complete.

Q1JAI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKEVIVESF ELDHTIVKAP YVRLISEEFG PKGDRITNFD VRLVQPNQNS
60 70 80 90 100
IETAGLHTIE HLLAKLIRQR IDGMIDCSPF GCRTGFHLIM WGKHSSTDIA
110 120 130 140 150
KVIKSSLEEI ATGITWEDVP GTTLESCGNY KDHSLFAAKE WAQLIIDQGI
160
SDDPFSRHVI
Length:160
Mass (Da):17,979
Last modified:August 21, 2007 - v2
Checksum:iA45592396C76BD21
GO

Sequence cautioni

The sequence ABF36423 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA Translation: ABF36423.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABF36423; ABF36423; MGAS2096_Spy1371
KEGGispj:MGAS2096_Spy1371

Similar proteinsi

Entry informationi

Entry nameiLUXS_STRPB
AccessioniPrimary (citable) accession number: Q1JAI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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