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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc1
Metal bindingi41Zinc1
Metal bindingi56Zinc1
Metal bindingi59Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 59C4-typeAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:6.4.1.2)
Short name:
ACCase subunit beta
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene namesi
Name:accD
Ordered Locus Names:MGAS2096_Spy1512
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003898741 – 288Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST288

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Structurei

3D structure databases

ProteinModelPortaliQ1JA97.
SMRiQ1JA97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 288CoA carboxyltransferase N-terminalAdd BLAST255

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 59C4-typeAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000021671.
KOiK01963.
OMAiPEGLWIK.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JA97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFRKKDKY IRITPNNSLK GSVSHNVPEV PDELFAKCPA CKHMIYKKDL
60 70 80 90 100
GLAKICPTCS YNFRISAQER LTLTVDEGSF QELFTSIETK DPLRFPGYQE
110 120 130 140 150
KLQKAKETTG LHEAVLTGKA MVKEQKIALA IMDSHFIMAS MGTVVGEKIT
160 170 180 190 200
RLFELAIEEN LPVVIFTASG GARMQEGIMS LMQMAKVSAA VKRHSNAGLF
210 220 230 240 250
YLTILTDPTT GGVTASFAME GDIILAEPQS LVGFAGRRVI ETTVRENLPD
260 270 280
DFQKAEFLQD HGFVDAIVKR TELRDKIAHL VAFHGGGQ
Length:288
Mass (Da):31,826
Last modified:June 13, 2006 - v1
Checksum:i02E6B0DC2718FB95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF36564.1.
RefSeqiWP_010922590.1. NC_008023.1.

Genome annotation databases

EnsemblBacteriaiABF36564; ABF36564; MGAS2096_Spy1512.
KEGGispj:MGAS2096_Spy1512.

Similar proteinsi

Entry informationi

Entry nameiACCD_STRPB
AccessioniPrimary (citable) accession number: Q1JA97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: June 13, 2006
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families