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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-1583-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:MGAS2096_Spy1514
OrganismiStreptococcus pyogenes serotype M12 (strain MGAS2096)
Taxonomic identifieri370553 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1391393-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000340805Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1JA95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000277829.
KOiK02372.
OMAiEMMCARR.
OrthoDBiPOG091H005Q.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ. 1 hit.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1JA95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIREIQAAL PHRYPMLLVD RVLEVSDDHI VAIKNVTINE PFFNGHFPHY
60 70 80 90 100
PVMPGVLIME ALAQTAGVLE LSKEENKGKL VFYAGMDKVK FKKQVVPGDQ
110 120 130
LVMTATFIKR RGTIAVVEAR AEVDGKLAAS GTLTFACGQ
Length:139
Mass (Da):15,324
Last modified:June 10, 2008 - v2
Checksum:i06090333FC20B479
GO

Sequence cautioni

The sequence ABF36566 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF36566.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABF36566; ABF36566; MGAS2096_Spy1514.
KEGGispj:MGAS2096_Spy1514.
PATRICi19733569. VBIStrPyo133020_1551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000261 Genomic DNA. Translation: ABF36566.1. Different initiation.

3D structure databases

ProteinModelPortaliQ1JA95.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF36566; ABF36566; MGAS2096_Spy1514.
KEGGispj:MGAS2096_Spy1514.
PATRICi19733569. VBIStrPyo133020_1551.

Phylogenomic databases

HOGENOMiHOG000277829.
KOiK02372.
OMAiEMMCARR.
OrthoDBiPOG091H005Q.

Enzyme and pathway databases

BioCyciSPYO370553:GH2N-1583-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ. 1 hit.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABZ_STRPB
AccessioniPrimary (citable) accession number: Q1JA95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.