Q1JA50 (ALR_STRPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	MGAS2096_Spy1559

Organism

Streptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP]

Taxonomic identifier

370553 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Alanine racemase HAMAP MF_01201		PRO_1000066046
Sites
	Active site	40	1	Proton acceptor; specific for D-alanine By similarity
	Active site	263	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	40	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1JA50 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 24045246DBB1659B	FASTA	366	39,919
	10 20 30 40 50 60 MISSFHRPTV ARVNLQAIKE NVASVQKHIP LGVKTYAVVK ADAYGHGAVQ VSKALLPQVD 70 80 90 100 110 120 GYCVSNLDEA LQLRQAGIDK EILILGVLLP NELELAVANA ITVTIASLDW IALARLEKKE 130 140 150 160 170 180 CQGLKVHVKV DSGMGRIGLR SSKEVNLLID SLKELGADVE GIFTHFATAD EADDTKFNQQ 190 200 210 220 230 240 LQFFKKLIAG LEDKPRLVHA SNSATSIWHS DTIFNAVRLG IVSYGLNPSG SDLSLPFPLQ 250 260 270 280 290 300 EALSLESSLV HVKMISAGDT VGYGVTYTAK KSEYVGTVPI GYADGWTRNM QGFSVLVDGQ 310 320 330 340 350 360 FCEIIGRVSM DQLTIRLSKA YPLGTKVTLI GSNQQKNIST TDIANYRNTI NYEVLCLLSD RIPRIY

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS2096.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000261 Genomic DNA. Translation: ABF36611.1.
RefSeq	YP_601155.1. NC_008023.1.
3D structure databases
ProteinModelPortal	Q1JA50.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JA50.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000044248; EBSTRP00000042554; EBSTRG00000044242.
GeneID	4065361.
GenomeReviews	Gene locus MGAS2096_Spy1559 in contig CP000261_GR.
KEGG	spj:MGAS2096_Spy1559.
PATRIC	19733665. VBIStrPyo133020_1599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0787.
GeneTree	EBGT00050000028408.
HOGENOM	HBG712172.
OMA	TRKEDAN.
PhylomeDB	Q1JA50.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	SPYO370553:MGAS2096_SPY1559-MONOMER.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. Alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_STRPB

Accession

Primary (citable) accession number: Q1JA50

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program