Q1JA49 (ACPS_STRPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS

Gene names

Name:	acpS
Ordered Locus Names:	MGAS2096_Spy1560

Organism

Streptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP]

Taxonomic identifier

370553 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	Holo-[acyl-carrier-protein] synthase HAMAP MF_00101		PRO_1000008510
Sites
	Metal binding	8	1	Magnesium By similarity
	Metal binding	58	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1JA49 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 5AE97877F973BDBC	FASTA	118	13,290
	10 20 30 40 50 60 MIVGHGIDLQ EISAIEKVYQ RNPRFAQKIL TEQELAIFES FPYKRRLSYL AGRWSGKEAF 70 80 90 100 110 VKAIGTGIGR LTFQDIEILN DVRGCPILTK SPFKGNSFIS ISHSGNYVQA SVILEDKK

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS2096.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000261 Genomic DNA. Translation: ABF36612.1.
RefSeq	YP_601156.1. NC_008023.1.
3D structure databases
ProteinModelPortal	Q1JA49.
SMR	Q1JA49. Positions 1-116.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1JA49.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000044437; EBSTRP00000042743; EBSTRG00000044430.
GeneID	4065362.
GenomeReviews	Gene locus MGAS2096_Spy1560 in contig CP000261_GR.
KEGG	spj:MGAS2096_Spy1560.
PATRIC	19733667. VBIStrPyo133020_1600.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0736.
GeneTree	EBGT00050000027655.
HOGENOM	HBG734479.
OMA	IFPSITH.
ProtClustDB	PRK00070.
Enzyme and pathway databases
BioCyc	SPYO370553:MGAS2096_SPY1560-MONOMER.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPS_STRPB

Accession

Primary (citable) accession number: Q1JA49

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program